{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T07:06:39Z","timestamp":1765609599859},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,11,22]],"date-time":"2013-11-22T00:00:00Z","timestamp":1385078400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Altered gait patterns, muscle weakness and atrophy have been reported in young boys with severe haemophilia when compared to unaffected peers. The aim of this study was to determine whether lateral gastrocnemius muscle size and architecture influenced biomechanical walking patterns of boys with haemophilia and if these relationships differed from age\u2010matched typically developing boys. Biomechanical function of the knee and ankle during level walking, lateral gastrocnemius anatomical cross\u2010sectional area, thickness, width, fascicle length and pennation angle and ankle plantar flexor muscle strength were recorded in 19 typically developing boys aged 7\u201312\u00a0years and 19 age\u2010matched haemophilic boys with a history of ankle joint bleeding. Associations between gait, strength and architecture were compared using correlations of peak gait values. Haemophilic boys walked with significantly larger (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.05) ankle dorsi flexion angles and knee flexion moments. The ankle plantar flexor muscles of haemophilic boys were significantly weaker and smaller when compared to typically developing peers. In the typically developing boys there was no apparent association between muscle architecture, strength and walking patterns. In haemophilic boys maximum muscle strength and <jats:styled-content style=\"fixed-case\">ACSA<\/jats:styled-content> normalized torque of the ankle plantar flexors together with the muscle width, thickness, fascicle length and angulation (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.05) were associated with motion at the ankle and peak moments at the knee joint. Muscle strength deficits of the ankle plantar flexors and changes in muscle size and architecture may underpin the key biomechanical alterations in walking patterns of haemophilic boys with a history of ankle joint bleeding.<\/jats:p>","DOI":"10.1111\/hae.12317","type":"journal-article","created":{"date-parts":[[2013,11,23]],"date-time":"2013-11-23T04:35:45Z","timestamp":1385181345000},"page":"413-420","source":"Crossref","is-referenced-by-count":13,"title":["Influence of ankle plantar flexor muscle architecture and strength on gait in boys with haemophilia in comparison to typically developing children"],"prefix":"10.1111","volume":"20","author":[{"given":"D.","family":"Stephensen","sequence":"first","affiliation":[{"name":"School of Health, Sport and Bioscience University of East London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. I.","family":"Drechsler","sequence":"additional","affiliation":[{"name":"School of Health, Sport and Bioscience University of East London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O. M.","family":"Scott","sequence":"additional","affiliation":[{"name":"School of Health, Sport and Bioscience University of East London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,11,22]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2008.01876.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1351-8216.2001.00119.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2006.01953.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2011.04214.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa067659"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2011.02705.x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2008.01934.x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2012.02768.x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2007.01429.x"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2011.02606.x"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.22098"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiomech.2007.03.004"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2009.03307.x"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00376443"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.2522\/ptj.20090377"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.23326"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2004.05.013"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jelekin.2007.02.009"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/BPO.0b013e3181558943"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-9457(85)90004-1"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.2000.00439.x"},{"key":"e_1_2_9_23_1","first-page":"3","volume-title":"Communications","author":"Asmussen E","year":"1959"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pep.0000202097.76939.0e"},{"key":"e_1_2_9_25_1","doi-asserted-by":"crossref","first-page":"354","DOI":"10.2106\/00004623-198062030-00005","article-title":"The role of the ankle plantar flexors in normal walking","volume":"62","author":"Sutherland D","year":"1980","journal-title":"J Bone Joint Surg"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/ca.10064"},{"key":"e_1_2_9_27_1","first-page":"73","article-title":"Changes in human muscle architecture in disuse atrophy evaluated by ultrasound imaging","volume":"5","author":"Narici M","year":"1998","journal-title":"Journal of Gravitational Physiology"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00433.2003"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1993.74.6.2740"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004210000298"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2007.01535.x"},{"key":"e_1_2_9_32_1","first-page":"425","article-title":"Investigations of quadriceps inhibition: implications for clinical practice","volume":"70","author":"Stokes M","year":"1984","journal-title":"Physiotherapy"}],"container-title":["Haemophilia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhae.12317","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hae.12317","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T08:15:13Z","timestamp":1695543313000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hae.12317"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,22]]},"references-count":31,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["10.1111\/hae.12317"],"URL":"https:\/\/doi.org\/10.1111\/hae.12317","archive":["Portico"],"relation":{},"ISSN":["1351-8216","1365-2516"],"issn-type":[{"value":"1351-8216","type":"print"},{"value":"1365-2516","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,22]]}}}