{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T04:31:38Z","timestamp":1771648298988,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,12,16]],"date-time":"2013-12-16T00:00:00Z","timestamp":1387152000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The penetration of beta energy of 153\u2010samarium (<jats:sup>153<\/jats:sup>Sm) (0.8\u00a0MeV) is not only appropriate for synovectomy of median articulations but is possible to improve the radiobiological effect using increased activities. The aim of this study was to assess the effectiveness of 185\u00a0<jats:styled-content style=\"fixed-case\">MB<\/jats:styled-content>q and 740\u00a0<jats:styled-content style=\"fixed-case\">MB<\/jats:styled-content>q of 153\u2010samarium hydroxyapatite (<jats:sup>153<\/jats:sup>Sm\u2010<jats:styled-content style=\"fixed-case\">HA<\/jats:styled-content>) in knees of haemophilic patients. Thirty\u2010one patients \u2013 36 knees, 30 males, were divided into two groups without coinjection of corticosteroid: A \u2013 14 patients (17 knees) treated with intra\u2010articular dose of 185\u00a0<jats:styled-content style=\"fixed-case\">MB<\/jats:styled-content>q of <jats:sup>153<\/jats:sup>Sm\u2010<jats:styled-content style=\"fixed-case\">HA<\/jats:styled-content>, average age 23\u00a0years; B \u2013 17 patients (19 knees) with 740\u00a0<jats:styled-content style=\"fixed-case\">MB<\/jats:styled-content>q of <jats:sup>153<\/jats:sup>Sm\u2010<jats:styled-content style=\"fixed-case\">HA<\/jats:styled-content>, average age 21.3\u00a0years. The evaluation before and after 1\u00a0year of synovectomy used the following criteria: reduction in the number of haemarthroses and use of the coagulation factor and improvement in articular motility. Adverse\u2010effects occurrence was considered too. Early and late scintigraphic studies were performed after synoviorthesis and no joint immobilization was recommended. The reduction in haemarthrosis and use of coagulation factor were: group 1 \u2013 31.3% and 25%; group 2 \u2013 81.5% and 79% with <jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.001 respectively; no significant improvement in knees motility was noted for both groups. Four cases of mild reactional synovitis were observed in each group. The scintigraphic control showed homogenous distribution of the radiopharmaceuticals with no articular escape; the material was considered safe by its permanence in the articulation. We have significant improvement in the synovectomy of haemophilic knees with 740\u00a0<jats:styled-content style=\"fixed-case\">MB<\/jats:styled-content>q of <jats:sup>153<\/jats:sup>Sm\u2010<jats:styled-content style=\"fixed-case\">HA<\/jats:styled-content>; the less penetration of its beta radiation was compensated by the increased biological effect with the higher used activity.<\/jats:p>","DOI":"10.1111\/hae.12319","type":"journal-article","created":{"date-parts":[[2013,12,16]],"date-time":"2013-12-16T07:18:41Z","timestamp":1387178321000},"page":"421-425","source":"Crossref","is-referenced-by-count":22,"title":["The use of 185\u00a0<scp>MB<\/scp>q and 740\u00a0<scp>MB<\/scp>q of 153\u2010samarium hydroxyapatite for knee synovectomy in haemophilia"],"prefix":"10.1111","volume":"20","author":[{"given":"J. U. M.","family":"Calegaro","sequence":"first","affiliation":[{"name":"Grupo N\u00facleos of Nuclear Medicine Hospital de Base Brasilia DF Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Machado","sequence":"additional","affiliation":[{"name":"Orthopedic Service Hospital de Base Brasilia DF Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. G.","family":"Furtado","sequence":"additional","affiliation":[{"name":"Grupo N\u00facleos of Nuclear Medicine Hospital de Base Brasilia DF Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. S. C.","family":"de Almeida","sequence":"additional","affiliation":[{"name":"International Hemophilia Training Center Brasilia DF Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. V. P.","family":"de Vasconcelos","sequence":"additional","affiliation":[{"name":"Orthopedic Service Hospital de Base Brasilia DF Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. F.","family":"de Barboza","sequence":"additional","affiliation":[{"name":"Radiopharmaceutical Center \u2010 IPEN\/CNEN S\u00e3o Paulo SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. P.","family":"de Paula","sequence":"additional","affiliation":[{"name":"Secretaria de Estado de Sa\u00fade do DF Brasilia DF Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,12,16]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"60","article-title":"General orthopedics: a tribute to J. Vernon Luck. Symposium: Surgical management of advanced hemophilic arthropathy: an overview of 20 years\u2019 experience","volume":"242","author":"Luck JV","year":"1989","journal-title":"Clin Orthop"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2011.02615.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2007.081182"},{"key":"e_1_2_5_5_1","first-page":"212","volume-title":"Proc VII Congress World Federation of Hemophilia","author":"Ahlberg A","year":"1971"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/17453677908989797"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2008.01908.x"},{"issue":"1","key":"e_1_2_5_8_1","first-page":"102","article-title":"Sinovectomia com crescentes atividades de 153\u2010sam\u00e1rio hidroxiapatita em joelhos de pacientes hemof\u00edlicos","volume":"41","author":"Calegaro JUM","year":"2008","journal-title":"Radiol Bras"},{"issue":"1","key":"e_1_2_5_9_1","first-page":"95","article-title":"Preparation of hydroxiapatite (90Y\u2010HA) for synovectomy","volume":"39","author":"Couto RM","year":"2006","journal-title":"Radiol Bras"},{"issue":"1","key":"e_1_2_5_10_1","first-page":"4s","article-title":"Radiobiological principles in radionuclide therapy","volume":"46","author":"Kassis AL","year":"2005","journal-title":"J Nucl Med"},{"issue":"1","key":"e_1_2_5_11_1","first-page":"48s","article-title":"Radiosynovectomy in rheumatology, orthopedics, and hemophilia","volume":"46","author":"Schneider P","year":"2005","journal-title":"J Nucl Med"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.190.1.8259416"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0001-2998(97)80009-8"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/38.2.113"},{"key":"e_1_2_5_15_1","first-page":"1277","article-title":"Influence of radiation synovectomy on articular cartilage, synovial thickness and enhamcement as evidenced by MRI in patients with chronic synovitis","volume":"40","author":"Pirich C","year":"1999","journal-title":"J Nucl Med"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00808407"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2008.01691.x"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.rlu.0000134978.24797.3c"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830270107"},{"key":"e_1_2_5_20_1","first-page":"25","article-title":"Intraarticular dexamethasone in advanced chronic synovitis in hemophilia","volume":"343","author":"Frenandez\u2010Palazzi F","year":"1997","journal-title":"Clin Orthop Relat Res"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.58.9.554"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1807-59322009001200008"},{"key":"e_1_2_5_23_1","first-page":"1536","article-title":"Chemistry and biological behavior of samarium\u2010153 and rhenium\u2010186\u2010labeled hydroxyapatite particles: potential radiopharmaceuticals for radiation synovectomy","volume":"34","author":"Chinol M","year":"1993","journal-title":"J Nucl Med"},{"key":"e_1_2_5_24_1","first-page":"51","article-title":"Samarium\u2010153\u2010particulate hydroxyapatite radiation synovectomy: biodistribution data for chronic knee synovitis","volume":"36","author":"Clunie G","year":"1995","journal-title":"J Nucl Med"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/38.4.316"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kem155"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.1994.tb01066.x"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2004.01035.x"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.62.3.251"}],"container-title":["Haemophilia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhae.12319","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hae.12319","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/hae.12319","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hae.12319","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T08:15:22Z","timestamp":1695543322000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hae.12319"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12,16]]},"references-count":28,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["10.1111\/hae.12319"],"URL":"https:\/\/doi.org\/10.1111\/hae.12319","archive":["Portico"],"relation":{},"ISSN":["1351-8216","1365-2516"],"issn-type":[{"value":"1351-8216","type":"print"},{"value":"1365-2516","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12,16]]}}}