{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T04:34:14Z","timestamp":1773203654479,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,3,3]],"date-time":"2014-03-03T00:00:00Z","timestamp":1393804800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Despite reliable results of ankle fusion for advanced haemophilic arthropathy, total ankle replacement (<jats:styled-content style=\"fixed-case\">TAR<\/jats:styled-content>) may be functionally advantageous. There is only very limited literature data available on <jats:styled-content style=\"fixed-case\">TAR<\/jats:styled-content> in patients with haemophilia. The objective of this study is to evaluate the short\u2010 and mid\u2010term results after <jats:styled-content style=\"fixed-case\">TAR<\/jats:styled-content> in patients with end\u2010stage haemophilic ankle arthropathy and concomitant virus infections. In a retrospective study, results after eleven <jats:styled-content style=\"fixed-case\">TAR<\/jats:styled-content> in 10 patients with severe (<jats:italic>n<\/jats:italic>\u00a0=\u00a08) and moderate (<jats:italic>n<\/jats:italic>\u00a0=\u00a02) haemophilia (mean age: 49\u00a0\u00b1\u00a07\u00a0years, range, 37\u201359) were evaluated at a mean follow\u2010up of 3.0\u00a0years (range, 1.2\u20135.4). Nine patients were positive for hepatitis C, five were <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010positive. Range of motion (<jats:styled-content style=\"fixed-case\">ROM<\/jats:styled-content>), <jats:styled-content style=\"fixed-case\">AOFAS<\/jats:styled-content>\u2010hindfoot\u2010score, pain status (visual analogue scale, <jats:styled-content style=\"fixed-case\">VAS<\/jats:styled-content>) as well as patient satisfaction were evaluated. In two cases deep prosthesis infection occurred leading to the removal of the implant. In the remaining eight patients the mean <jats:styled-content style=\"fixed-case\">AOFAS<\/jats:styled-content> score improved significantly from 21.5 to 68.0 points (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0005), the <jats:styled-content style=\"fixed-case\">VAS<\/jats:styled-content> score decreased significantly from 7.6 to 1.9 points (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0005). <jats:styled-content style=\"fixed-case\">ROM<\/jats:styled-content> increased from 23.2 to 25.0 degrees (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.51). At final follow\u2010up all patients without any complications were satisfied with the postoperative results. Radiographic examination did not reveal any signs of prosthetic loosening. <jats:styled-content style=\"fixed-case\">TAR<\/jats:styled-content> is a viable surgical treatment option in patients with end\u2010stage ankle osteoarthritis due to haemophilia. It provides significant pain relieve and high patient satisfaction. However, due to the increased risk of infection and lack of long\u2010term results, <jats:styled-content style=\"fixed-case\">TAR<\/jats:styled-content> particularly in patients with severe haemophilia and virus infections should be indicated carefully.<\/jats:p>","DOI":"10.1111\/hae.12392","type":"journal-article","created":{"date-parts":[[2014,3,4]],"date-time":"2014-03-04T02:19:59Z","timestamp":1393899599000},"page":"702-708","source":"Crossref","is-referenced-by-count":32,"title":["Total ankle replacement in patients with haemophilia and virus infections \u2013 a safe alternative to ankle arthrodesis?"],"prefix":"10.1111","volume":"20","author":[{"given":"A. C.","family":"Strauss","sequence":"first","affiliation":[{"name":"Department of Orthopaedics and Trauma Surgery University of Bonn Bonn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Goldmann","sequence":"additional","affiliation":[{"name":"Institute for Experimental Haematology and Transfusion Medicine University of Bonn Bonn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Wessling","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Trauma Surgery University of Bonn Bonn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Gravius","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Trauma Surgery University of Bonn Bonn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. C.","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Trauma Surgery University of Bonn Bonn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. D.","family":"Wimmer","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Trauma Surgery University of Bonn Bonn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. C.","family":"Wirtz","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Trauma Surgery University of Bonn Bonn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Oldenburg","sequence":"additional","affiliation":[{"name":"Institute for Experimental Haematology and Transfusion Medicine University of Bonn Bonn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. 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