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Typically, twice or thrice weekly infusions of factor <jats:styled-content style=\"fixed-case\">VIII<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">IX<\/jats:styled-content> concentrates are integral to this treatment approach. Secondary prophylaxis is initiated after the relentless cycle of progressive joint damage has been triggered by prior haemarthroses and is intended to preserve existing joint health by preventing additional spontaneous bleeding events. Event\u2010driven prophylaxis involves the administration of clotting factor concentrates to prevent acute traumatic bleeds, which are anticipated to occur in association with surgical or physical trauma. This regimen enhances the effectiveness of primary or secondary prophylaxis protocols or on\u2010demand approaches to replacement therapy. Besides the marked reduction in the so\u2010called annual bleed rate, prophylaxis regimens frequently increase personal self\u2010confidence to embark on a more active and physical lifestyle; however, in reality, prophylaxis must be individualized in accordance with bleeding phenotypes, with the unique pharmacokinetic profile of administered replacement clotting factor concentrates, with the specific clinical scenario, and with the degree of intensity anticipated for any physical activity. The introduction of extended half\u2010life replacement products will also influence how these prophylaxis regimens will be accomplished. The following scenarios will discuss how prophylaxis regimens can be implemented to protect the individual from developing spontaneous and activity\u2010induced acute bleeding complications and to maintain an improved quality of life.<\/jats:p>","DOI":"10.1111\/hae.12425","type":"journal-article","created":{"date-parts":[[2014,4,25]],"date-time":"2014-04-25T09:03:49Z","timestamp":1398416629000},"page":"106-113","source":"Crossref","is-referenced-by-count":16,"title":["Prophylaxis in real life scenarios"],"prefix":"10.1111","volume":"20","author":[{"given":"K.","family":"Fischer","sequence":"first","affiliation":[{"name":"Van Creveldkliniek University Medical Center Utrecht Utrecht The Netherlands"},{"name":"Julius Center for Health Sciences and Primary Care University Medical Center Utrecht Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Konkle","sequence":"additional","affiliation":[{"name":"Puget Sound Blood Center University of Washington School of Medicine Seattle WA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Broderick","sequence":"additional","affiliation":[{"name":"School of Medical Sciences University of New South Wales Sydney NSW Australia"},{"name":"Children's Hospital Institute of Sports Medicine at Westmead Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. 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