{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T10:35:32Z","timestamp":1787654132152,"version":"build-2736575974"},"reference-count":65,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,4,8]],"date-time":"2014-04-08T00:00:00Z","timestamp":1396915200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Prophylaxis is considered optimal care for children and adults with severe haemophilia A because of its proven ability to reduce joint and other bleeding episodes. However, a \u2018one size fits all\u2019 approach to prophylaxis is not ideal, potentially leading to over\u2010treatment in some individuals and under\u2010treatment in others. Moreover, a generic plan fails to take into account a patient's lifestyle and personal preferences. This article reviews the factors contributing to bleeding risk and joint damage and uses case studies to illustrate how these contributors can be weighed to individualize the prophylactic regimen, thereby increasing the likelihood of therapeutic success.<\/jats:p>","DOI":"10.1111\/hae.12438","type":"journal-article","created":{"date-parts":[[2014,4,8]],"date-time":"2014-04-08T10:46:04Z","timestamp":1396953964000},"page":"607-615","source":"Crossref","is-referenced-by-count":59,"title":["Considerations in individualizing prophylaxis in patients with haemophilia A"],"prefix":"10.1111","volume":"20","author":[{"given":"L. 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