{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T05:00:06Z","timestamp":1761541206645},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,8,7]],"date-time":"2014-08-07T00:00:00Z","timestamp":1407369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:sec><jats:title>\n<jats:bold>Summary<\/jats:bold>\n<\/jats:title><jats:p>von Willebrand disease (VWD) is the commonest inherited bleeding disorder. Management of major surgery or bleeding often requires treatment with a plasma\u2010derived (pd) VWF\/FVIII containing concentrate. Wilate<jats:sup>\u00ae<\/jats:sup> is a dual\u2010virally inactivated pd\u2010concentrate, produced specifically for the treatment of VWD, containing physiological (1:1) ratios of VWF: FVIII. We reviewed efficacy and safety of Wilate<jats:sup>\u00ae<\/jats:sup> usage (2007\u20132012) at our centre including 2\u00a0years following product switching the majority of patients. Clinical and laboratory data of all adult patients treated with Wilate<jats:sup>\u00ae<\/jats:sup> during the study period were evaluated. Fifty four patients used 3\u00a0972\u00a0150\u00a0IU of Wilate<jats:sup>\u00ae<\/jats:sup> (1378 infusions) between 1\/3\/07 and 1\/5\/12. Efficacy was rated as being excellent or good in 94% of surgical episodes (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>70; 34 patients) and 98% of bleeding\/traumatic episodes (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>46; 25 patients). Eight patients (2\u00a0636\u00a0100\u00a0IU) were managed on home treatment regimens. Two patients switched to Wilate<jats:sup>\u00ae<\/jats:sup> prophylaxis in the evaluation period, demonstrating similar efficacy to a previous product. Incremental recoveries (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>37) were 2.24\u00a0IU\u00a0dL<jats:sup>\u22121<\/jats:sup> per IU\u00a0kg<jats:sup>\u22121<\/jats:sup> for FVIII:C, 2.39\u00a0IU\u00a0dL<jats:sup>\u22121<\/jats:sup> per IU\u00a0kg<jats:sup>\u22121<\/jats:sup> for VWF:Ag and 1.88\u00a0IU\u00a0dL<jats:sup>\u22121<\/jats:sup> per IU\u00a0kg<jats:sup>\u22121<\/jats:sup> for VWF:RCo. Six adverse events occurred in six patients (11.1% patients) over 1378 infusions (0.44%). Half of these were retrospectively felt to be infusion speed related. No notable accumulation of FVIII was seen in patients treated for \u22653\u00a0days. There was no treatment failure, thrombosis, transfusion transmitted infection or inhibitory VWF antibodies seen. Our findings confirm safety and efficacy of Wilate<jats:sup>\u00ae<\/jats:sup> in an adult VWD population with lack of notable FVIII accumulation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hae.12496","type":"journal-article","created":{"date-parts":[[2014,8,7]],"date-time":"2014-08-07T15:21:33Z","timestamp":1407424893000},"page":"846-853","source":"Crossref","is-referenced-by-count":14,"title":["Safety and efficacy of a von Willebrand factor\/factor <scp>VIII<\/scp> concentrate (Wilate<sup>\u00ae<\/sup>): a single centre experience"],"prefix":"10.1111","volume":"20","author":[{"given":"P.","family":"Batty","sequence":"first","affiliation":[{"name":"The Royal London Hospital Haemophilia Centre Barts and The London School of Medicine and Dentistry The Royal London Hospital Whitechapel London E1 1BB UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y. \u2010H.","family":"Chen","sequence":"additional","affiliation":[{"name":"The Royal London Hospital Haemophilia Centre Barts and The London School of Medicine and Dentistry The Royal London Hospital Whitechapel London E1 1BB UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Bowles","sequence":"additional","affiliation":[{"name":"The Royal London Hospital Haemophilia Centre Barts and The London School of Medicine and Dentistry The Royal London Hospital Whitechapel London E1 1BB UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. P.","family":"Hart","sequence":"additional","affiliation":[{"name":"The Royal London Hospital Haemophilia Centre Barts and The London School of Medicine and Dentistry The Royal London Hospital Whitechapel London E1 1BB UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Platton","sequence":"additional","affiliation":[{"name":"The Royal London Hospital Haemophilia Centre Barts and The London School of Medicine and Dentistry The Royal London Hospital Whitechapel London E1 1BB UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. J.","family":"Pasi","sequence":"additional","affiliation":[{"name":"The Royal London Hospital Haemophilia Centre Barts and The London School of Medicine and Dentistry The Royal London Hospital Whitechapel London E1 1BB UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,8,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V69.2.454.454"},{"key":"e_1_2_8_3_1","unstructured":"United Kingdom Haemophilia Centres Doctors' Organisation.Bleeding disorder statistics for April 2011 to March 2012: a report from the national haemophilia database.1\u201387.2012."},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2004.00886.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-01-479527"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2008.01695.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biologicals.2005.11.010"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH11-02-0057"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH10-10-0631"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2004.00894.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.2002.00587.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1612977"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.300.6719.230"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2008.01901.x"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mbc.0000167658.85143.49"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2011.02745.x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1613227"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1613225"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2012.02758.x"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra040403"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2011.02603.x"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/MBC.0b013e3283504118"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12078"}],"container-title":["Haemophilia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhae.12496","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hae.12496","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T14:55:01Z","timestamp":1695480901000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hae.12496"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8,7]]},"references-count":22,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,11]]}},"alternative-id":["10.1111\/hae.12496"],"URL":"https:\/\/doi.org\/10.1111\/hae.12496","archive":["Portico"],"relation":{},"ISSN":["1351-8216","1365-2516"],"issn-type":[{"value":"1351-8216","type":"print"},{"value":"1365-2516","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,7]]}}}