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Few studies have examined orthopaedic complications and outcomes in <jats:styled-content style=\"fixed-case\">VWD<\/jats:styled-content> patients treated for end\u2010stage ankle <jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content> with total ankle replacement (<jats:styled-content style=\"fixed-case\">TAR<\/jats:styled-content>). To determine the clinical presentation, intraoperative and postoperative complications and evaluate the mid\u2010term outcome in <jats:styled-content style=\"fixed-case\">VWD<\/jats:styled-content> patients treated with <jats:styled-content style=\"fixed-case\">TAR<\/jats:styled-content>. Eighteen patients with VWD with mean age 47.3\u00a0years (range\u00a0=\u00a034.0\u201368.7) were treated for end\u2010stage ankle <jats:styled-content style=\"fixed-case\">OA<\/jats:styled-content> with <jats:styled-content style=\"fixed-case\">TAR<\/jats:styled-content>. The mean duration of follow\u2010up was 7.5\u00a0years (range\u00a0=\u00a02.9\u201313.2). Intraoperative and perioperative complications were recorded. Component stability was assessed with weight\u2010bearing radiographs. Clinical evaluation included range of motion (<jats:styled-content style=\"fixed-case\">ROM<\/jats:styled-content>) tests using a goniometer and under fluoroscopy using a lateral view. Clinical outcomes were analysed by a visual analogue scale, the American Orthopaedic Foot and Ankle Society hindfoot score and Short Form (36) Health Survey (<jats:styled-content style=\"fixed-case\">SF<\/jats:styled-content>\u201036) health survey. One patient sustained an intraoperative medial malleolar fracture. In two patients delayed wound healing was observed. Two secondary major surgeries were performed. Pain level decreased from 8.2\u00a0\u00b1\u00a00.9 (range\u00a0=\u00a07\u201310) preoperatively to 1.1\u00a0\u00b1\u00a01.2 (range\u00a0=\u00a00\u20134) postoperatively. Significant functional improvement including <jats:styled-content style=\"fixed-case\">ROM<\/jats:styled-content> was observed. All categories of <jats:styled-content style=\"fixed-case\">SF<\/jats:styled-content>\u201036 score showed significant improvement in quality of life. Mid\u2010term results of <jats:styled-content style=\"fixed-case\">TAR<\/jats:styled-content> in patients with <jats:styled-content style=\"fixed-case\">VWD<\/jats:styled-content> are encouraging. The total rate of intraoperative and postoperative complications was 33.3%. However, longer term outcomes are necessary to fully understand the clinical benefit of <jats:styled-content style=\"fixed-case\">TAR<\/jats:styled-content> in patients with <jats:styled-content style=\"fixed-case\">VWD<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/hae.12561","type":"journal-article","created":{"date-parts":[[2015,2,16]],"date-time":"2015-02-16T07:47:26Z","timestamp":1424072846000},"source":"Crossref","is-referenced-by-count":19,"title":["Total ankle replacement in patients with von Willebrand disease: mid\u2010term results of 18 procedures"],"prefix":"10.1111","volume":"21","author":[{"given":"K.","family":"Barg","sequence":"first","affiliation":[{"name":"Orthopaedic Department University Hospital of Basel Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Wiewiorski","sequence":"additional","affiliation":[{"name":"Orthopaedic Department University Hospital of Basel Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. 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