{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T05:58:55Z","timestamp":1767851935013,"version":"3.49.0"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,3,4]],"date-time":"2015-03-04T00:00:00Z","timestamp":1425427200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The study was undertaken to document cartilage and soft tissue changes\/findings in ankles and knees of normal children of different age groups to be used for comparison in the assessment of children with haemophilia. Cartilage thickness and soft tissue changes were recorded at predetermined sites of ankles\/knees on both US and MRI in healthy boys in three age groups: 7\u20139; 10\u201314; and 15\u201318\u00a0years. To assess the validity of the ultrasound and MRI measurements, an <jats:italic>ex vivo<\/jats:italic> study was done using agar phantoms with techniques and scanners similar to those applied <jats:italic>in vivo<\/jats:italic>. Twenty (48%) knees and 22 (52%) ankles of 42 boys, were evaluated. There was a reduction in the thickness of joint cartilage with age. A difference in cartilage measurements was noted in most sites between the age groups on both US and MRI (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.05 each), but such difference was not noted for joint fluid in ankles or knees (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.20, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.68 or <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.75, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.63 for US, MRI, respectively). Although cartilage measurements were smaller on US than on MRI for both ankles and knees\u00a0(<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.05 each), this observation was not recorded for fluid in knees (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.02). For diminutive measurements (2\u00a0mm) mean US measurements were smaller than corresponding phantom's measurements, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.02. Age\u2010related measurements were noted for cartilage thickness on US and MRI in ankles and knees. US measurements were smaller than corresponding MRI measurements at most joint sites, which were supported by results on small\u2010diameter phantoms.<\/jats:p>","DOI":"10.1111\/hae.12614","type":"journal-article","created":{"date-parts":[[2015,3,4]],"date-time":"2015-03-04T10:25:42Z","timestamp":1425464742000},"source":"Crossref","is-referenced-by-count":32,"title":["Ultrasound and magnetic resonance imaging of healthy paediatric ankles and knees: a baseline for comparison with haemophilic joints"],"prefix":"10.1111","volume":"21","author":[{"given":"S. N.","family":"Keshava","sequence":"first","affiliation":[{"name":"Department of Radiology Christian, Medical College Vellore Tamil Nadu India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. V.","family":"Gibikote","sequence":"additional","affiliation":[{"name":"Department of Radiology Christian, Medical College Vellore Tamil Nadu India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Mohanta","sequence":"additional","affiliation":[{"name":"Department of Radiology The Hospital for Sick Children Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Poonnoose","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Christian Medical College Vellore Tamil Nadu India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Rayner","sequence":"additional","affiliation":[{"name":"Department of Radiology The Hospital for Sick Children Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Hilliard","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Services The Hospital for Sick Children Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. M.","family":"Lakshmi","sequence":"additional","affiliation":[{"name":"Department of Haematology Christian Medical College Vellore Tamil Nadu India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Moineddin","sequence":"additional","affiliation":[{"name":"Department of Family and Community Medicine University of Toronto Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Ignas","sequence":"additional","affiliation":[{"name":"Department of Child Health Evaluative Sciences The Hospital for Sick Children Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Srivastava","sequence":"additional","affiliation":[{"name":"Department of Haematology Christian Medical College Vellore Tamil Nadu India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Blanchette","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Oncology The Hospital for Sick Children Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. S.","family":"Doria","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging The Hospital for Sick Children Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,3,4]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008480-200202000-00008"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2011.02615.x"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2012.02883.x"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2006.01414.x"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2009.02016.x"},{"issue":"2","key":"e_1_2_13_7_1","first-page":"1","article-title":"Sonography for assessment of elbows in haemophilic children: a systematic protocol","volume":"2161","author":"Xavier F","year":"2012","journal-title":"Rheumatology (Current Research)"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2010.02380.x"},{"key":"e_1_2_13_9_1","first-page":"191","volume-title":"Textbook of Hemophilia","author":"Doria AS","year":"2009"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.100101"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2012.31.1.49"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1245374"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12107"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.20667"},{"key":"e_1_2_13_15_1","first-page":"72","article-title":"MRI evaluation of growth plate closure rate and pattern in the normal knee joint","volume":"15","author":"Sasaki T","year":"2002","journal-title":"J Knee Surg"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2501071322"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11832-008-0121-1"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0301-5629(95)00044-5"},{"key":"e_1_2_13_19_1","volume-title":"Statistics at Square One ed. 9th","author":"Swinscow TDV","year":"1997"},{"key":"e_1_2_13_20_1","first-page":"404","volume-title":"Practical Statistics for Medical Research","author":"Altman DG","year":"1991"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2007.01602.x"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.1999.00608.x"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-198405000-00041"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.12.019"},{"key":"e_1_2_13_25_1","first-page":"48","volume-title":"Diagnostic Ultrasound: Principles, Instrumentation and Exercises","author":"Kremkau FW","year":"1984"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2702.2010.03301.x"}],"container-title":["Haemophilia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhae.12614","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hae.12614","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/hae.12614","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hae.12614","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T12:32:46Z","timestamp":1692880366000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hae.12614"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3,4]]},"references-count":25,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["10.1111\/hae.12614"],"URL":"https:\/\/doi.org\/10.1111\/hae.12614","archive":["Portico"],"relation":{},"ISSN":["1351-8216","1365-2516"],"issn-type":[{"value":"1351-8216","type":"print"},{"value":"1365-2516","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,4]]}}}