{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T21:44:58Z","timestamp":1791409498410,"version":"4.3.3"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,2,16]],"date-time":"2015-02-16T00:00:00Z","timestamp":1424044800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Chang Gung Memorial Hospital Research Project Grant, Taiwan","award":["CMRPG 6C0181 & 6C0182"],"award-info":[{"award-number":["CMRPG 6C0181 & 6C0182"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>In patients with haemophilia A, repeated occurrences of haemarthrosis and synovitis lead to limitations in range of motion (<jats:styled-content style=\"fixed-case\">ROM<\/jats:styled-content>) of major joints. However, the effect of limitations in joint <jats:styled-content style=\"fixed-case\">ROM<\/jats:styled-content> on health\u2010related quality of life (<jats:styled-content style=\"fixed-case\">HRQOL<\/jats:styled-content>) in these patients has not been studied previously. The aim of this study was to assess the impact of <jats:styled-content style=\"fixed-case\">ROM<\/jats:styled-content> limitations of 10 major joints (bilateral shoulders, elbows, hips, knees and ankles), combined with other possibly influential factors, on <jats:styled-content style=\"fixed-case\">HRQOL<\/jats:styled-content> in patients with haemophilia A. The <jats:styled-content style=\"fixed-case\">ROM<\/jats:styled-content> limitations in 13 movements and pain intensity of the 10 major joints were measured. The socio\u2010demographic and clinical data were recorded. Short\u2010Form 36 was used as the <jats:styled-content style=\"fixed-case\">HRQOL<\/jats:styled-content> measurement. Eighteen patients (mean age: 36.9\u00a0years) were included. Hip <jats:styled-content style=\"fixed-case\">ROM<\/jats:styled-content> limitations, knee <jats:styled-content style=\"fixed-case\">ROM<\/jats:styled-content> limitations and hip pain intensity predicted physical functioning scale (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001; adjusted <jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a00.553). Shoulder <jats:styled-content style=\"fixed-case\">ROM<\/jats:styled-content> limitations and age predicted role limitation were due to emotional problems scale (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001; adjusted <jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a00.373). Elbow <jats:styled-content style=\"fixed-case\">ROM<\/jats:styled-content> limitations and haemophilia severity predicted mental health scale (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.001; adjusted <jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a00.320). Hip <jats:styled-content style=\"fixed-case\">ROM<\/jats:styled-content> limitations predicted social functioning scale (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.041; adjusted <jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a00.091). Educational level and elbow <jats:styled-content style=\"fixed-case\">ROM<\/jats:styled-content> limitations predicted vitality scale (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001; adjusted <jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a00.416). The <jats:styled-content style=\"fixed-case\">ROM<\/jats:styled-content> limitations of hip, knee, shoulder and elbow could be predictors for <jats:styled-content style=\"fixed-case\">HRQOL<\/jats:styled-content> in patients with haemophilia A. Improving <jats:styled-content style=\"fixed-case\">ROM<\/jats:styled-content> of major joints could be an appropriate treatment strategy to enhance <jats:styled-content style=\"fixed-case\">HRQOL<\/jats:styled-content> in these patients.<\/jats:p>","DOI":"10.1111\/hae.12644","type":"journal-article","created":{"date-parts":[[2015,2,16]],"date-time":"2015-02-16T08:06:48Z","timestamp":1424074008000},"source":"Crossref","is-referenced-by-count":23,"title":["The impact of joint range of motion limitations on health\u2010related quality of life in patients with haemophilia A: a prospective study"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9838-0096","authenticated-orcid":false,"given":"C.\u2010M.","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation Chang Gung Memorial Hospital Chiayi Taiwan"},{"name":"School of Medicine College of Medicine Chang Gung University Taoyuan Taiwan"},{"name":"Haemophilia and Thrombosis Treatment Center Chang Gung Memorial Hospital Chiayi Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.\u2010C.","family":"Huang","sequence":"additional","affiliation":[{"name":"School of Medicine College of Medicine Chang Gung University Taoyuan Taiwan"},{"name":"Haemophilia and Thrombosis Treatment Center Chang Gung Memorial Hospital Chiayi Taiwan"},{"name":"Department of Orthopaedic Surgery Chang Gung Memorial Hospital Chiayi Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.\u2010C.","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Medicine College of Medicine Chang Gung University Taoyuan Taiwan"},{"name":"Haemophilia and Thrombosis Treatment Center Chang Gung Memorial Hospital Chiayi Taiwan"},{"name":"Division of Hematology and Oncology Department of Medicine Chang Gung Memorial Hospital Chiayi 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