{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T14:03:53Z","timestamp":1775138633545,"version":"3.50.1"},"reference-count":13,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,4,30]],"date-time":"2015-04-30T00:00:00Z","timestamp":1430352000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>In contrast to haemophilia B, allergic manifestations are rare complications in haemophilia A (<jats:styled-content style=\"fixed-case\">HA<\/jats:styled-content>) patients treated with factor VIII (FVIII) concentrates. Nevertheless, it can be serious and hamper replacement therapy in these cases. The aims of this study were to evaluate the frequency of allergic reaction in a cohort of <jats:styled-content style=\"fixed-case\">HA<\/jats:styled-content> patients treated only with plasma\u2010derived FVIII (pdFVIII) concentrates, and assess the possible immune mechanisms involved. History of allergic reaction was retrospectively assessed. Patients with allergic manifestations were followed, and had plasma samples collected in different timepoints in relation to the allergic episode. These samples were analysed for the presence of inhibitor and anti\u2010FVIII immunoglobulins subclasses. Three of 322 <jats:styled-content style=\"fixed-case\">HA<\/jats:styled-content> patients (0.9%) developed allergic reaction after exposure to pdFVIII products during the last 15\u00a0years in our centre. The first patient, with severe <jats:styled-content style=\"fixed-case\">HA<\/jats:styled-content>, without inhibitor, had anti\u2010pdFVIII IgE and IgG4, but no anti\u2010recombinant FVIII (rFVIII) IgE. The second patient, with severe <jats:styled-content style=\"fixed-case\">HA<\/jats:styled-content>, and high\u2010responding inhibitor, presented allergic manifestation with both, pdFVIII concentrate and activated prothrombin complex concentrate. Although anti\u2010pdFVIII and anti\u2010rFVIII IgG4 were detected, no anti\u2010FVIII IgE was present. The third patient, with moderate <jats:styled-content style=\"fixed-case\">HA<\/jats:styled-content> without inhibitor, atopic, had no anti\u2010FVIII immunoglobulin detected, and allergic symptoms disappeared after switching to rFVIII concentrate. This study corroborates the low incidence of allergic reactions in <jats:styled-content style=\"fixed-case\">HA<\/jats:styled-content> patients. In the three cases presented, the anti\u2010FVIII immunoglobulin profile demonstrated that the allergic manifestation was triggered by other proteins contained in pdFVIII products, and not directed to FVIII.<\/jats:p>","DOI":"10.1111\/hae.12647","type":"journal-article","created":{"date-parts":[[2015,4,30]],"date-time":"2015-04-30T12:02:57Z","timestamp":1430395377000},"source":"Crossref","is-referenced-by-count":8,"title":["Allergic reaction in a cohort of haemophilia A patients using plasma\u2010derived factor VIII (FVIII) concentrate is rare and not necessarily triggered by FVIII"],"prefix":"10.1111","volume":"21","author":[{"given":"S. A. L.","family":"Montalv\u00e3o","sequence":"first","affiliation":[{"name":"Hemophilia Unit \u2018Cl\u00e1udio L. P. Correa\u2019 INCT do Sangue Hemocentro de Campinas Centro de Hematologia e Hemoterapia da Unicamp University of Campinas Campinas Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. C.","family":"Tucunduva","sequence":"additional","affiliation":[{"name":"Hemophilia Unit \u2018Cl\u00e1udio L. P. Correa\u2019 INCT do Sangue Hemocentro de Campinas Centro de Hematologia e Hemoterapia da Unicamp University of Campinas Campinas Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. H.","family":"Siqueira","sequence":"additional","affiliation":[{"name":"Hemophilia Unit \u2018Cl\u00e1udio L. P. Correa\u2019 INCT do Sangue Hemocentro de Campinas Centro de Hematologia e Hemoterapia da Unicamp University of Campinas Campinas Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. L. A.","family":"Sambo","sequence":"additional","affiliation":[{"name":"Hemophilia Unit \u2018Cl\u00e1udio L. P. Correa\u2019 INCT do Sangue Hemocentro de Campinas Centro de Hematologia e Hemoterapia da Unicamp University of Campinas Campinas Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. S.","family":"Medina","sequence":"additional","affiliation":[{"name":"Hemophilia Unit \u2018Cl\u00e1udio L. P. Correa\u2019 INCT do Sangue Hemocentro de Campinas Centro de Hematologia e Hemoterapia da Unicamp University of Campinas Campinas Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. C.","family":"Ozelo","sequence":"additional","affiliation":[{"name":"Hemophilia Unit \u2018Cl\u00e1udio L. P. Correa\u2019 INCT do Sangue Hemocentro de Campinas Centro de Hematologia e Hemoterapia da Unicamp University of Campinas Campinas Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,4,30]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2011.02436.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.1970.tb01445.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.1999.t01-1-00293.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1996.36496226153.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2000-9824"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004310050774"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1979.tb00485.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-07-444877"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.2002.00674.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.12.981"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2006.01339.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1653759"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2012.04705.x"}],"container-title":["Haemophilia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhae.12647","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hae.12647","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T16:26:58Z","timestamp":1695572818000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hae.12647"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4,30]]},"references-count":13,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["10.1111\/hae.12647"],"URL":"https:\/\/doi.org\/10.1111\/hae.12647","archive":["Portico"],"relation":{},"ISSN":["1351-8216","1365-2516"],"issn-type":[{"value":"1351-8216","type":"print"},{"value":"1365-2516","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,30]]}}}