{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T07:03:42Z","timestamp":1781507022422,"version":"3.54.1"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,2,17]],"date-time":"2015-02-17T00:00:00Z","timestamp":1424131200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007305","name":"MCHB","doi-asserted-by":"crossref","award":["H30MC24050"],"award-info":[{"award-number":["H30MC24050"]}],"id":[{"id":"10.13039\/100007305","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Sparse data are available on presentation and management of acute coronary syndromes (<jats:styled-content style=\"fixed-case\">ACS<\/jats:styled-content>), including unstable angina and non\u2010<jats:styled-content style=\"fixed-case\">ST<\/jats:styled-content>\u2010 and <jats:styled-content style=\"fixed-case\">ST<\/jats:styled-content>\u2010elevation myocardial infarction, among persons with haemophilia (<jats:styled-content style=\"fixed-case\">PWH<\/jats:styled-content>). The aim of this study was to determine demographics, bleeding disorder characteristics, cardiovascular risk factors (<jats:styled-content style=\"fixed-case\">CRF<\/jats:styled-content>s), interventions, haemostatic protocol, revascularization outcomes and complications among <jats:styled-content style=\"fixed-case\">PWH<\/jats:styled-content> with <jats:styled-content style=\"fixed-case\">ACS<\/jats:styled-content>. Members of an international consortium comprising &gt;2000 adult <jats:styled-content style=\"fixed-case\">PWH<\/jats:styled-content> retrospectively completed case report forms for episodes of <jats:styled-content style=\"fixed-case\">ACS<\/jats:styled-content> in a &gt;10\u2010year follow\u2010up period (2003\u20132013). Twenty <jats:styled-content style=\"fixed-case\">ACS<\/jats:styled-content> episodes occurred among 19 patients [rate, 0.8% (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.4, 1.2)]. Seven patients (37%) were aged &lt;50\u00a0years; 10 (53%) had \u22653 <jats:styled-content style=\"fixed-case\">CRF<\/jats:styled-content>s. In 5\/20 episodes (25%), the initial <jats:styled-content style=\"fixed-case\">ACS<\/jats:styled-content> management protocol was altered because of the bleeding disorder. None of the eight patients with severe haemophilia underwent coronary artery bypass grafting (<jats:styled-content style=\"fixed-case\">CABG<\/jats:styled-content>), compared with 54.5% of patients with non\u2010severe disease (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.02). Revascularization with percutaneous coronary intervention (<jats:styled-content style=\"fixed-case\">PCI<\/jats:styled-content>) or <jats:styled-content style=\"fixed-case\">CABG<\/jats:styled-content> was rated successful in 13\/13 cases, with no excessive bleeding during initial management. During chronic exposure to antiplatelet agents, secondary haemophilia prophylaxis was more prevalent in patients with severe haemophilia compared with non\u2010severe haemophilia (85.7% vs. 30%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.05). No <jats:styled-content style=\"fixed-case\">ACS<\/jats:styled-content>\u2010related deaths occurred during initial management, but one patient with severe haemophilia A died of undetermined cause 36\u00a0months after the <jats:styled-content style=\"fixed-case\">ACS<\/jats:styled-content> event while on aspirin therapy. ACS occurs even among relatively younger <jats:styled-content style=\"fixed-case\">PWH<\/jats:styled-content>, typically in association with multiple <jats:styled-content style=\"fixed-case\">CRF<\/jats:styled-content>s. Revascularization with <jats:styled-content style=\"fixed-case\">PCI<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">CABG<\/jats:styled-content> is feasible, and antiplatelet agents plus secondary prophylaxis appears to be well tolerated in selected <jats:styled-content style=\"fixed-case\">PWH<\/jats:styled-content> with <jats:styled-content style=\"fixed-case\">ACS<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/hae.12652","type":"journal-article","created":{"date-parts":[[2015,2,17]],"date-time":"2015-02-17T11:29:55Z","timestamp":1424172595000},"page":"589-597","source":"Crossref","is-referenced-by-count":43,"title":["Presentation and management of acute coronary syndromes among adult persons with haemophilia: results of an international, retrospective, 10\u2010year survey"],"prefix":"10.1111","volume":"21","author":[{"given":"P. F.","family":"Fogarty","sequence":"first","affiliation":[{"name":"Penn Comprehensive Hemophilia and Thrombosis Program Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. E.","family":"Mancuso","sequence":"additional","affiliation":[{"name":"Angelo Bianchi Bonomi Hemophilia and Thrombosis Center Fondazione IRCCS Ca\u2019 Granda, Ospedale Maggiore Policlinico Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Kasthuri","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology Hemophilia and Thrombosis Center University of North Carolina Chapel Hill NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Bidlingmaier","sequence":"additional","affiliation":[{"name":"Munich Hemophilia Centre Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Chitlur","sequence":"additional","affiliation":[{"name":"Children's Hospital of Michigan Detroit MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Gomez","sequence":"additional","affiliation":[{"name":"Royal Free Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. A.","family":"Holme","sequence":"additional","affiliation":[{"name":"Department of Haematology Oslo University Hospital, Rikshospitalet Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"James","sequence":"additional","affiliation":[{"name":"Queen's University Kingston ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Kruse\u2010Jarres","sequence":"additional","affiliation":[{"name":"Tulane University School of Medicine New Orleans LA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Mahlangu","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences University of the Witwatersrand and Charlotte Maxeke Johannesburg Academic Hospital Johannesburg South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. E.","family":"Mingot\u2010Castellano","sequence":"additional","affiliation":[{"name":"Regional University Hospital Carlos Haya Malaga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Soni","sequence":"additional","affiliation":[{"name":"Children's Hospital of Orange County Orange CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the Global Emerging HEmophilia Panel (GEHEP)","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,2,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2009.03669.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.111.238162"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/hc3501.094232"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-10-050435"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2006.01808.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2008.01791.x"},{"key":"e_1_2_8_8_1","first-page":"823","article-title":"Mortality in patients with hemophilia. 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