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We tried to investigate the functional properties of the joint and cartilage in experimental haemarthrosis (<jats:styled-content style=\"fixed-case\">EH<\/jats:styled-content>) after <jats:styled-content style=\"fixed-case\">MSC<\/jats:styled-content>s intra\u2010articular (<jats:styled-content style=\"fixed-case\">IA<\/jats:styled-content>) injection. One millilitre of fresh autologous blood was injected twice a week for three consecutive weeks in three groups including control haemophilia 10\u00a0days (<jats:italic>n<\/jats:italic>\u00a0=\u00a08), control haemophilia 38\u00a0days (<jats:italic>n<\/jats:italic>\u00a0=\u00a08) and <jats:styled-content style=\"fixed-case\">MSC<\/jats:styled-content>s (<jats:italic>n<\/jats:italic>\u00a0=\u00a08) group. In later, 10\u00a0days after the end of <jats:styled-content style=\"fixed-case\">IA<\/jats:styled-content> blood injections, <jats:styled-content style=\"fixed-case\">MSC<\/jats:styled-content>s <jats:styled-content style=\"fixed-case\">IA<\/jats:styled-content> injection was performed. Eight animals received no treatment as the normal control group. Thirty\u2010eight\u00a0days after the end of <jats:styled-content style=\"fixed-case\">IA<\/jats:styled-content> blood injections, animals were sacrificed. Joint friction and stress\u2010relaxation tests were done, inflammatory cytokines of synovial membrane and scanning electron microscopy of the cartilage assessed. Joint friction decreased in <jats:styled-content style=\"fixed-case\">MSC<\/jats:styled-content>s in comparison to other groups and was significant with normal control group, (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.011). The mechanical properties of cartilage showed no significant differences between groups. Tumour necrosis factor alpha and interleukin 1 beta decreased and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20104 very slightly increased in <jats:styled-content style=\"fixed-case\">MSC<\/jats:styled-content>s in comparison to the time\u2010matched control group. Scanning electron microscopy enabled acquisition of good structural properties of the surface and layers of the cartilage after <jats:styled-content style=\"fixed-case\">MSC<\/jats:styled-content>s injection. The hole induced in the medial plateau of the tibia bones, after inducing haemarthrosis, were covered with cartilage\u2010like structure. The results showed that <jats:styled-content style=\"fixed-case\">MSC<\/jats:styled-content>s <jats:styled-content style=\"fixed-case\">IA<\/jats:styled-content> injection has some beneficial effects on cartilage structure and function in haemarthrosis model and is promising in patients with haemophilia.<\/jats:p>","DOI":"10.1111\/hae.12659","type":"journal-article","created":{"date-parts":[[2015,4,28]],"date-time":"2015-04-28T05:53:48Z","timestamp":1430200428000},"page":"693-701","source":"Crossref","is-referenced-by-count":12,"title":["Experimental study on the role of intra\u2010articular injection of MSCs on cartilage regeneration in haemophilia"],"prefix":"10.1111","volume":"21","author":[{"given":"R.","family":"Ravanbod","sequence":"first","affiliation":[{"name":"Department of Physical Therapy Biomechanical Research Laboratory Tarbiat Modares University Tehran 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