{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T15:24:32Z","timestamp":1792855472090,"version":"4.5.0"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,4,9]],"date-time":"2015-04-09T00:00:00Z","timestamp":1428537600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004191","name":"Novo Nordisk","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004191","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      Elderly patients with haemophilia (\n                      <jats:styled-content style=\"fixed-case\">PWH<\/jats:styled-content>\n                      ) suffer from both haemarthrosis and haemophilic arthropathy (\n                      <jats:styled-content style=\"fixed-case\">HA<\/jats:styled-content>\n                      ). Diagnosis of haemarthrosis in\n                      <jats:styled-content style=\"fixed-case\">PWH<\/jats:styled-content>\n                      is currently based on clinical presentation. No diagnostic protocols or validated criteria are available to identify haemarthrosis or to differentiate haemarthrosis from\n                      <jats:styled-content style=\"fixed-case\">HA<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>\n                      The aim of this study is to identify symptoms and signs that can be used to differentiate haemarthrosis from\n                      <jats:styled-content style=\"fixed-case\">HA<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A narrative literature review was performed on symptoms associated with haemarthrosis and symptoms associated with\n                      <jats:styled-content style=\"fixed-case\">HA<\/jats:styled-content>\n                      . Additionally, literature on the diagnosis of haemarthrosis in patients without haemophilia, imaging techniques and biomarkers was searched.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      This review shows that there is no consensus about the symptoms associated with haemarthrosis and that there is limited literature about the symptoms associated with\n                      <jats:styled-content style=\"fixed-case\">HA<\/jats:styled-content>\n                      . Additionally, symptoms associated with haemarthrosis partly overlap with symptoms of\n                      <jats:styled-content style=\"fixed-case\">HA<\/jats:styled-content>\n                      , particularly those symptoms associated with flare\u2010ups of\n                      <jats:styled-content style=\"fixed-case\">HA<\/jats:styled-content>\n                      . Due to the overlap in symptoms differentiating between these conditions is complex. Furthermore, differentiating based on imaging techniques or biomarkers causes practical difficulties.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Despite the overlap in symptoms, differentiating between joint bleeds and flare\u2010ups of\n                      <jats:styled-content style=\"fixed-case\">HA<\/jats:styled-content>\n                      based on clinical presentation still seems the most convenient and practical solution. Further research is necessary to identify specific symptoms that can be used to differentiate between the two conditions.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hae.12667","type":"journal-article","created":{"date-parts":[[2015,4,9]],"date-time":"2015-04-09T02:47:22Z","timestamp":1428547642000},"page":"289-296","source":"Crossref","is-referenced-by-count":48,"title":["Differentiating between signs of intra\u2010articular joint bleeding and chronic arthropathy in haemophilia: a narrative review of the literature"],"prefix":"10.1111","volume":"21","author":[{"given":"M. A.","family":"Timmer","sequence":"first","affiliation":[{"name":"Van Creveldkliniek University Medical Center Utrecht Utrecht the Netherlands"},{"name":"Physical Therapy Research Department of Rehabilitation, Nursing Science and Sport Brain Center Rudolf Magnus University Medical Center Utrecht Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. F.","family":"Pisters","sequence":"additional","affiliation":[{"name":"Physical Therapy Research Department of Rehabilitation, Nursing Science and Sport Brain Center Rudolf Magnus University Medical Center Utrecht Utrecht the Netherlands"},{"name":"Center for Physical Therapy Research and Innovation in Primary Care Leidsche Rijn Julius Health Care Centers Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"de Kleijn","sequence":"additional","affiliation":[{"name":"Van Creveldkliniek University Medical Center Utrecht Utrecht the Netherlands"},{"name":"Physical Therapy Research Department of Rehabilitation, Nursing Science and Sport Brain Center Rudolf Magnus University Medical Center Utrecht Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. 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