{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T19:43:27Z","timestamp":1766087007474},"reference-count":46,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,4,9]],"date-time":"2015-04-09T00:00:00Z","timestamp":1428537600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Many paediatric patients with haemophilia who might benefit from radiosynovectomy (<jats:styled-content style=\"fixed-case\">RS<\/jats:styled-content>) for the control of synovitis do not undergo the procedure as there is controversy in the literature regarding the safety of radiation exposure after two cases of acute lymphocytic leukaemia in children with haemophilia treated with <jats:sup>32<\/jats:sup>P <jats:styled-content style=\"fixed-case\">RS<\/jats:styled-content> were reported. The purpose of this review was to analyse the safety of <jats:styled-content style=\"fixed-case\">RS<\/jats:styled-content> in paediatric patients with haemophilia and provide a risk\u2010benefit assessment, which practitioners could apply to their patients. Children undergoing knee <jats:styled-content style=\"fixed-case\">RS<\/jats:styled-content> receive a radiation dose of approximately 0.74\u00a0mSv (90 megabecquerels\u2010MBq) and elbow and ankle <jats:styled-content style=\"fixed-case\">RS<\/jats:styled-content>s a dose of approximately 0.32\u00a0mSv (30\u201340\u00a0MBq). The radiation dose from natural sources is approximately 2\u00a0mSv and the recommended limit for patients (apart from natural sources) is 1\u00a0mSv per year. The lifetime cancer risk increases about 0.5% per 100\u00a0mSv per year. Considering the risks and benefits of <jats:styled-content style=\"fixed-case\">RS<\/jats:styled-content>, the authors recommend that clinicians consider this procedure in children with inhibitors or in patients without inhibitors when bleeding is recurrent and persistent despite aggressive factor replacement.<\/jats:p>","DOI":"10.1111\/hae.12668","type":"journal-article","created":{"date-parts":[[2015,4,9]],"date-time":"2015-04-09T07:06:21Z","timestamp":1428563181000},"page":"411-418","source":"Crossref","is-referenced-by-count":28,"title":["Safety of radiation exposure after radiosynovectomy in paediatric patients with haemophilia"],"prefix":"10.1111","volume":"21","author":[{"given":"E. C.","family":"Rodriguez\u2010Merchan","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery La Paz University Hospital Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. 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