{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:59:12Z","timestamp":1780361952898,"version":"3.54.1"},"reference-count":43,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,4,30]],"date-time":"2015-04-30T00:00:00Z","timestamp":1430352000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Acquired von Willebrand syndrome is a rare bleeding disorder and treatment of the associated gastrointestinal (<jats:styled-content style=\"fixed-case\">GI<\/jats:styled-content>) bleeding due to angiodysplasia is challenging.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of this study was to present a new case on the successful use of thalidomide in a patient with acquired von Willebrand syndrome and recurrent angiodysplasia\u2010related <jats:styled-content style=\"fixed-case\">GI<\/jats:styled-content> bleedings, and to conduct a literature review on the use of thalidomide in patients with <jats:styled-content style=\"fixed-case\">GI<\/jats:styled-content> angiodysplasia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A literature review was conducted, searching the electronic databases PubMed, Embase and Cochrane.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We present a 75\u2010year\u2010old woman with IgG <jats:styled-content style=\"fixed-case\">MGUS<\/jats:styled-content>\u2010associated acquired von Willebrand syndrome (<jats:styled-content style=\"fixed-case\">AVWS<\/jats:styled-content>) who suffered from recurrent gastrointestinal (<jats:styled-content style=\"fixed-case\">GI<\/jats:styled-content>) bleedings and epistaxis. Treatment with immunoglobulins, desmopressin, Haemate\u2010P and blood transfusions failed to achieve long\u2010term haemostasis. Eventually, after these bleedings relapsed for almost a decade at 1\u2010 to 3\u2010month intervals, thalidomide was prescribed. Since then, only one single nose bleed and one single melaena episode had occurred. She currently remains in remission of <jats:styled-content style=\"fixed-case\">GI<\/jats:styled-content> bleeds after 3\u00a0years and 3\u00a0months follow\u2010up. The literature review revealed a beneficial effect of thalidomide in reducing <jats:styled-content style=\"fixed-case\">GI<\/jats:styled-content> bleeding due to angiodysplasia, including four case reports on inherited von Willebrand disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In conclusion, thalidomide can be a reasonable option for the treatment of recurrent <jats:styled-content style=\"fixed-case\">GI<\/jats:styled-content> bleeding due to angiodysplasia in <jats:styled-content style=\"fixed-case\">AVWS<\/jats:styled-content> and we report for the first time that refractory or relapsing <jats:styled-content style=\"fixed-case\">GI<\/jats:styled-content> bleeding in patients with <jats:styled-content style=\"fixed-case\">AVWS<\/jats:styled-content> can successfully be controlled with thalidomide.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hae.12701","type":"journal-article","created":{"date-parts":[[2015,4,30]],"date-time":"2015-04-30T12:01:33Z","timestamp":1430395293000},"page":"419-429","source":"Crossref","is-referenced-by-count":25,"title":["Thalidomide for treatment of gastrointestinal bleedings due to angiodysplasia: a case report in acquired von Willebrand syndrome and review of the literature"],"prefix":"10.1111","volume":"21","author":[{"given":"E. 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