{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T03:46:37Z","timestamp":1767066397586,"version":"3.37.3"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,6,24]],"date-time":"2015-06-24T00:00:00Z","timestamp":1435104000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000014","name":"Canadian Blood Services","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000014","id-type":"DOI","asserted-by":"crossref"}]},{"name":"H\u00e9ma Quebec Partnership Fund"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Haemophilia A treatment with factor <jats:styled-content style=\"fixed-case\">VIII<\/jats:styled-content> concentrates requires frequent venipunctures; a central venous access device (<jats:styled-content style=\"fixed-case\">CVAD<\/jats:styled-content>) may be required to facilitate reliable venous access, especially in young children. While <jats:styled-content style=\"fixed-case\">CVAD<\/jats:styled-content>s provide reliable venous access, complications such as infection and thrombosis may occur.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of this study was to assess <jats:styled-content style=\"fixed-case\">CVAD<\/jats:styled-content> use in the Canadian Hemophilia Primary Prophylaxis Study (<jats:styled-content style=\"fixed-case\">CHPS<\/jats:styled-content>), a single\u2010arm, multi\u2010centre prospective study whereby factor use is tailored to individual prophylactic need.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Participants received a tailored, escalating dose, prophylaxis regimen of increasing frequency of <jats:styled-content style=\"fixed-case\">FVIII<\/jats:styled-content> infusions: step\u20101: 50\u00a0IU\u00a0kg<jats:sup>\u22121<\/jats:sup> once weekly; step\u20102: 30\u00a0IU\u00a0kg<jats:sup>\u22121<\/jats:sup> twice weekly; and step\u20103: 25\u00a0IU\u00a0kg<jats:sup>\u22121<\/jats:sup> on alternate days, according to their level of bleeding. <jats:styled-content style=\"fixed-case\">CVAD<\/jats:styled-content> insertion was at the discretion of the local health care team. Details regarding <jats:styled-content style=\"fixed-case\">CVAD<\/jats:styled-content> use during this protocol were analysed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty six boys were enrolled, 21 required 25 <jats:styled-content style=\"fixed-case\">CVAD<\/jats:styled-content>s due to difficult venous access. <jats:styled-content style=\"fixed-case\">CVAD<\/jats:styled-content>s were inserted at a median age of 1.3\u00a0years (range: 0.6\u20132.1) and were removed at a median age of 8.7\u00a0years (range 6.3\u201311.8). Six participants experienced non\u2010life threatening <jats:styled-content style=\"fixed-case\">CVAD<\/jats:styled-content>\u2010complications, the most frequent being device malfunction requiring <jats:styled-content style=\"fixed-case\">CVAD<\/jats:styled-content> replacement (<jats:italic>n<\/jats:italic>\u00a0=\u00a04). Two boys were shown to have <jats:styled-content style=\"fixed-case\">CVAD<\/jats:styled-content>\u2010associated thrombosis detected on routine imaging; one required removal due to infusion difficulties and the other was asymptomatic and did not require device removal. No <jats:styled-content style=\"fixed-case\">CVAD<\/jats:styled-content>\u2010related infections were documented.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study shows that the <jats:styled-content style=\"fixed-case\">CHPS<\/jats:styled-content> tailored prophylaxis regimen is associated with a decreased requirement for <jats:styled-content style=\"fixed-case\">CVAD<\/jats:styled-content>s and with few device\u2010related complications.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hae.12713","type":"journal-article","created":{"date-parts":[[2015,6,25]],"date-time":"2015-06-25T08:07:16Z","timestamp":1435219636000},"page":"469-476","source":"Crossref","is-referenced-by-count":15,"title":["Experience with central venous access devices (<scp>CVAD<\/scp>s) in the Canadian hemophilia primary prophylaxis study (<scp>CHPS<\/scp>)"],"prefix":"10.1111","volume":"21","author":[{"given":"A. R.","family":"Langley","sequence":"first","affiliation":[{"name":"Division of Hematology\/Oncology The Hospital for Sick Children Toronto ON"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. 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