{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T06:51:09Z","timestamp":1792047069628,"version":"4.4.0"},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T00:00:00Z","timestamp":1436832000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Bayer Healthcare Canada Inc."}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Osteoporosis is common in haemophilic arthropathy. Quantitative ultrasound (<jats:styled-content style=\"fixed-case\">QUS<\/jats:styled-content>) can be a suitable alternative for dual\u2010energy x\u2010ray absorptiometry for diagnosing osteoporosis in haemophiliacs due to its lack of ionizing radiation, and ease to use.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>We investigated the intra\u2010 and inter\u2010operator reliability of <jats:styled-content style=\"fixed-case\">QUS<\/jats:styled-content>, its responsiveness to bone growth, its ability to differentiate bone adjacent to blood\u2010injected vs. control joints, and the effect of soft tissues on the speed of sound (<jats:styled-content style=\"fixed-case\">SOS<\/jats:styled-content>) <jats:styled-content style=\"fixed-case\">QUS<\/jats:styled-content> values in a juvenile white New Zealand rabbit model of blood\u2010induced arthritis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eight of 16 rabbits were injected with autologous blood (0.1\u00a0mL\u00a0kg<jats:sup>\u22121<\/jats:sup>) 8 times over a 17\u2010week period, the remaining eight rabbits served as controls. <jats:styled-content style=\"fixed-case\">SOS<\/jats:styled-content> was measured at baseline, weeks 8 and 17 <jats:italic>in\u00a0vivo<\/jats:italic> and after the bones were excised on week 17.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Intra\u2010 and inter\u2010operator coefficients of variation for <jats:styled-content style=\"fixed-case\">QUS<\/jats:styled-content> data were &lt;5% and intraclass correlation coefficients were &gt;60% for 22\/27 (81.5%) of bones assessed. The level of interval increase in <jats:styled-content style=\"fixed-case\">SOS<\/jats:styled-content> values from baseline to week 17 was significantly different in tibiae of injected, contralateral to injected and non\u2010injected knee groups by <jats:sc>anova<\/jats:sc> (<jats:italic>P\u00a0<\/jats:italic>=\u00a00.01). <jats:italic>In vivo<\/jats:italic> (mean\u00a0\u00b1\u00a0<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>, 4147.17\u00a0\u00b1\u00a096.27\u00a0m\u00a0s<jats:sup>\u22121<\/jats:sup>) and postmortem (4457.85\u00a0\u00b1\u00a0104.00\u00a0m\u00a0s<jats:sup>\u22121<\/jats:sup>) measurements on week 17 differed (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.01) indicating an effect of soft tissues on <jats:styled-content style=\"fixed-case\">SOS<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In conclusion, <jats:styled-content style=\"fixed-case\">QUS<\/jats:styled-content>' acceptable reliability, its responsiveness to growth\u2010related changes and its ability to discriminate injected and non\u2010injected joints make this technique a plausible candidate as a diagnostic tool for osteoporosis in the paediatic haemophilic population if these results are confirmed upon animal\u2013human translation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hae.12743","type":"journal-article","created":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T15:31:16Z","timestamp":1436887876000},"source":"Crossref","is-referenced-by-count":5,"title":["Longitudinal assessment of bone loss using quantitative ultrasound in a blood\u2010induced arthritis rabbit model"],"prefix":"10.1111","volume":"21","author":[{"given":"K. C.","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Diagnostic Imaging The Hospital for Sick Children Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Amirabadi","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging The Hospital for Sick Children Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. C.","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging The Hospital for Sick Children Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Moineddin","sequence":"additional","affiliation":[{"name":"Department of Family and Community Medicine University of Toronto Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Jong","sequence":"additional","affiliation":[{"name":"Department of Pathology Mount Sinai Hospital Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Tomlinson","sequence":"additional","affiliation":[{"name":"Department of Neonatology The Hospital for Sick Children Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. S.","family":"Doria","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging The Hospital for Sick Children Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,7,14]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.2003.00752.x"},{"key":"e_1_2_9_3_1","first-page":"715","volume-title":"Bone and Joint Imaging","author":"Resnick D","year":"1989"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008480-200202000-00008"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(93)90218-E"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-004-1761-8"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.061113"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1995.tb05557.x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2006.00985.x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.151S087"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-144-11-200606060-00009"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004310100849"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1439-0442.2003.00495.x"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2008.01963.x"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2012.02880.x"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780310910"},{"key":"e_1_2_9_17_1","first-page":"404","volume-title":"Practical Statistics for Medical Research","author":"Altman D","year":"1991"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1191\/1740774504cn057oa"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e3181df9c8c"},{"key":"e_1_2_9_20_1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s00223001090","article-title":"Comparison of quantitative calcaneal ultrasound and dual energy x\u2010ray absorptiometry in the evaluation of osteoporotic risk in children with chronic rheumatic diseases","volume":"67","author":"Falcini F","year":"2000","journal-title":"Calcif Tissue Int"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e3181f8b295"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2007.12.003"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2005.12.017"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e318074ccb3"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002230010027"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2007.12.003"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2007.06972.x"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-009-0759-x"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH09-09-0629"},{"key":"e_1_2_9_30_1","first-page":"82","article-title":"Osteoporosis\/Osteopenia and hemophilic arthropathy in severely hemophilic patients","volume":"15","author":"Naderi A","year":"2012","journal-title":"Arch of Iran Med"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00296057"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002239900287"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1385\/JCD:3:2:121"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(00)00249-0"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1109\/TUFFC.2008.821"}],"container-title":["Haemophilia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhae.12743","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hae.12743","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T19:58:06Z","timestamp":1695499086000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hae.12743"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,14]]},"references-count":34,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["10.1111\/hae.12743"],"URL":"https:\/\/doi.org\/10.1111\/hae.12743","archive":["Portico"],"relation":{},"ISSN":["1351-8216","1365-2516"],"issn-type":[{"value":"1351-8216","type":"print"},{"value":"1365-2516","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,14]]}}}