{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T06:13:04Z","timestamp":1789193584735,"version":"build-2803163510"},"reference-count":10,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T00:00:00Z","timestamp":1436832000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"CSL Behring"},{"name":"Bayer and Baxter"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2015,9]]},"abstract":"Introduction\/Aim<\/jats:title>Our aim was to generate, optimize and validate a self\u2010administered bleeding assessment tool (self\u2010BAT<\/jats:styled-content>) for von Willebrand disease (VWD<\/jats:styled-content>).<\/jats:p><\/jats:sec>Methods<\/jats:title>In Phase 1, medical terminology in the expert\u2010administered International Society on Thrombosis and Haemostasis (ISTH<\/jats:styled-content>)\u2010BAT<\/jats:styled-content> was converted into a Grade 4 reading level to produce the first version of the Self\u2010BAT<\/jats:styled-content> which was then optimized to ensure agreement with the ISTH<\/jats:styled-content>\u2010BAT<\/jats:styled-content>. In Phase 2, the normal range of bleeding scores (BSs) was determined and test\u2013retest reliability analysed. In Phase 3, the optimized Self\u2010BAT<\/jats:styled-content> was tested as a screening tool for first time referrals to the Haematology clinic.<\/jats:p><\/jats:sec>Results<\/jats:title>Bleeding score from the final optimized version of the Self\u2010BAT<\/jats:styled-content> showed an excellent intra\u2010class correlation coefficient (ICC<\/jats:styled-content>) of 0.87 with ISTH<\/jats:styled-content>\u2010BAT BS<\/jats:styled-content> in Phase 1. In Phase 2, the normal range of BSs for the optimized Self\u2010BAT<\/jats:styled-content> was determined to be 0 to +5 for females and 0 to +3 for males and excellent test\u2013retest reliability was shown (ICC<\/jats:styled-content>\u00a0=\u00a00.95). In Phase 3, we showed that a positive Self\u2010BAT BS<\/jats:styled-content> (\u22656 for females, \u22654 for males) has a sensitivity of 78%, specificity of 23%, positive predictive value (PPV<\/jats:styled-content>) of 0.15 and negative predictive value (NPV<\/jats:styled-content>) of 0.86 for VWD<\/jats:styled-content>; these figures improved when just the females were analysed; sensitivity of 100%, specificity of 21%, PPV<\/jats:styled-content>\u00a0=\u00a00.17 and NPV<\/jats:styled-content>\u00a0=\u00a01.0.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>We show an optimized Self\u2010BAT<\/jats:styled-content> can generate comparable BS<\/jats:styled-content> to the expert\u2010administered ISTH<\/jats:styled-content>\u2010BAT<\/jats:styled-content> and is a reliable, effective screening tool to incorporate into the assessment of individuals, particularly women, referred for a possible bleeding disorder.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hae.12747","type":"journal-article","created":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T19:26:49Z","timestamp":1436902009000},"source":"Crossref","is-referenced-by-count":85,"title":["Generation and optimization of the self\u2010administered bleeding assessment tool and its validation as a screening test for von Willebrand disease"],"prefix":"10.1111","volume":"21","author":[{"given":"M.","family":"Deforest","sequence":"first","affiliation":[{"name":"Department of Pathology and Molecular Medicine Queen's University Kingston ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Grabell","sequence":"additional","affiliation":[{"name":"Department of Medicine Queen's University Kingston ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Albert","sequence":"additional","affiliation":[{"name":"Department of Pathology and Molecular Medicine Queen's University Kingston ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Young","sequence":"additional","affiliation":[{"name":"Department of Pathology and Molecular Medicine Queen's University Kingston ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Tuttle","sequence":"additional","affiliation":[{"name":"Department of Pathology and Molecular Medicine Queen's University Kingston ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. M.","family":"Hopman","sequence":"additional","affiliation":[{"name":"Clinical Research Centre Kingston General Hospital Queen's University Kingston ON Canada"},{"name":"Department of Public Health Sciences Queen's University Kingston ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. D.","family":"James","sequence":"additional","affiliation":[{"name":"Department of Pathology and Molecular Medicine Queen's University Kingston ON Canada"},{"name":"Department of Medicine Queen's University Kingston ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,7,14]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2004.00991.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.21405"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2005.01663.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.22429"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2006.01847.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2008.03182.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2010.03796.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2010.03975.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2007.02790.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12503"}],"container-title":["Haemophilia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhae.12747","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hae.12747","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T19:58:09Z","timestamp":1695499089000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hae.12747"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,14]]},"references-count":10,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["10.1111\/hae.12747"],"URL":"https:\/\/doi.org\/10.1111\/hae.12747","archive":["Portico"],"relation":{},"ISSN":["1351-8216","1365-2516"],"issn-type":[{"value":"1351-8216","type":"print"},{"value":"1365-2516","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,14]]}}}