{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T10:23:52Z","timestamp":1791973432497,"version":"4.3.4"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,7,31]],"date-time":"2015-07-31T00:00:00Z","timestamp":1438300800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Patients with haemophilia tend to bleed in large joints even during prophylactic replacement therapy. Detection of early blood\u2010induced joint changes may improve monitoring of treatment. The aim of this study was to explore the value of routine ultrasound in detecting early joint abnormalities in children with haemophilia on prophylaxis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Sixty\u2010four joints in 32 children with haemophilia were examined by one operator using the Haemophilia Early Arthropathy Detection with UltraSound protocol during annual multidisciplinary follow\u2010up. Based on reported bleeding, the joint with the highest risk of blood\u2010induced joint damage and the contralateral joint were examined. At the same day, clinical function was assessed according to the Haemophilia Joint Health Score (\n                      <jats:styled-content style=\"fixed-case\">HJHS<\/jats:styled-content>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Median age was 11.5\u00a0years (range\u00a0=\u00a05.5\u201316.4). Out of the 64 examined joints, one ankle was excluded because of previous surgery. Median lifetime joint bleeds\/joint was three (interquartile ranges\u00a0=\u00a01\u20135). Clinical function of most joints was perfect: only 7\/49 joints with reported bleeds scored positive due to swelling, muscle atrophy and\/or range of motion loss (\n                      <jats:styled-content style=\"fixed-case\">HJHS<\/jats:styled-content>\n                      range\u00a0=\u00a01\u20132 points). Ultrasound showed abnormalities in 5\/49 joints with reported bleeding, and 4\/5 showed positive\n                      <jats:styled-content style=\"fixed-case\">HJHS<\/jats:styled-content>\n                      scores. Ultrasound abnormalities were present in 1\/56 joints (1.8%,\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      : 0.1\u20139.6%) without loss of clinical function.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Ultrasound abnormalities were found during routine evaluation of joints in children with haemophilia on prophylaxis. Most joints with ultrasound abnormalities showed low\n                      <jats:styled-content style=\"fixed-case\">HJHS<\/jats:styled-content>\n                      scores too. Ultrasound could be used to evaluate whether minimal losses of clinical function might be caused by anatomical changes.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hae.12769","type":"journal-article","created":{"date-parts":[[2015,7,31]],"date-time":"2015-07-31T02:13:36Z","timestamp":1438308816000},"page":"121-125","source":"Crossref","is-referenced-by-count":47,"title":["Value of routine ultrasound in detecting early joint changes in children with haemophilia using the \u2018Haemophilia Early Arthropathy Detection with UltraSound\u2019 protocol"],"prefix":"10.1111","volume":"22","author":[{"given":"W.","family":"Foppen","sequence":"first","affiliation":[{"name":"Department of Radiology University Medical Center (UMC) Utrecht Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. C.","family":"van der Schaaf","sequence":"additional","affiliation":[{"name":"Department of Radiology University Medical Center (UMC) Utrecht Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Fischer","sequence":"additional","affiliation":[{"name":"Van Creveldkliniek Department of Hematology University Medical Center (UMC) Utrecht Utrecht The Netherlands"},{"name":"Julius Center for Health Sciences and Primary Care University Medical Center (UMC) Utrecht Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,7,31]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2008.07386.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-197759030-00001"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.6161.469"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12175"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa067659"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2005.01061.x"},{"key":"e_1_2_7_8_1","first-page":"364","article-title":"Turning severe into moderate haemophilia by prophylaxis: are we reaching our goal?","volume":"11","author":"Uijl I","year":"2013","journal-title":"Blood Transfus"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2004.01036.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-198006000-00018"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2012.02883.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12248"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.2001.00509.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2011.02538.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2011.02680.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2006.01414.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2010.02380.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH12-11-0874"},{"key":"e_1_2_7_19_1","unstructured":"2012"},{"key":"e_1_2_7_20_1","volume-title":"Statistical Power Analysis for the Behavioural Sciences","author":"Cohen J","year":"1988"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2006.01312.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20353"},{"key":"e_1_2_7_23_1","first-page":"3","article-title":"Prophylaxis: musculoskeletal evaluation","volume":"30","author":"Gilbert MS","year":"1993","journal-title":"Semin Hematol"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12107"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12268"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12191"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12290"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2011.02513.x"}],"container-title":["Haemophilia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhae.12769","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hae.12769","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T05:27:15Z","timestamp":1695533235000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hae.12769"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,31]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["10.1111\/hae.12769"],"URL":"https:\/\/doi.org\/10.1111\/hae.12769","archive":["Portico"],"relation":{},"ISSN":["1351-8216","1365-2516"],"issn-type":[{"value":"1351-8216","type":"print"},{"value":"1365-2516","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,31]]}}}