{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T04:43:57Z","timestamp":1788669837486,"version":"build-2803163510"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,10,9]],"date-time":"2015-10-09T00:00:00Z","timestamp":1444348800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Fractures in persons with haemophilia (<jats:styled-content style=\"fixed-case\">PWH<\/jats:styled-content>) are not uncommon and require an interdisciplinary approach to maintain haemostasis during surgical treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of this study was to evaluate the perioperative management and outcome in <jats:styled-content style=\"fixed-case\">PWH<\/jats:styled-content> following fracture fixation compared to a matched non\u2010haemophilic control group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cohort of 44 <jats:styled-content style=\"fixed-case\">PWH<\/jats:styled-content> who underwent 46 surgical fracture fixations was retrospectively compared to 46 non\u2010haemophilic patients (matched\u2010pair controls). Patients were classified according to the fracture localization: (i) proximal upper extremity (Pr<jats:styled-content style=\"fixed-case\">UE<\/jats:styled-content>x; <jats:italic>n<\/jats:italic> = 7), (ii) distal upper extremity (Di<jats:styled-content style=\"fixed-case\">UE<\/jats:styled-content>x; <jats:italic>n<\/jats:italic> = 12), (iii) proximal lower extremity (Pr<jats:styled-content style=\"fixed-case\">LE<\/jats:styled-content>x; <jats:italic>n<\/jats:italic> = 13) and (iv) distal lower extremity (Di<jats:styled-content style=\"fixed-case\">LE<\/jats:styled-content>x; <jats:italic>n<\/jats:italic> = 14). Both groups were assessed for length of hospital stay, duration of surgery, drainage use and complication rates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was no significant difference regarding the duration of the preoperative hospital stay between <jats:styled-content style=\"fixed-case\">PWH<\/jats:styled-content> and controls. Only <jats:styled-content style=\"fixed-case\">PWH<\/jats:styled-content> who were operated at the Di<jats:styled-content style=\"fixed-case\">UE<\/jats:styled-content>x stayed significantly longer in hospital (4.8 \u00b1 3.7 days) than controls (2.2 \u00b1 2.3 days; <jats:italic>P<\/jats:italic> = 0.039). Operation time was significantly longer in <jats:styled-content style=\"fixed-case\">PWH<\/jats:styled-content> with fractures treated at the Di<jats:styled-content style=\"fixed-case\">LE<\/jats:styled-content>x (64.9 \u00b1 26.6 min) compared to the controls (49.8 \u00b1 37.9 min; <jats:italic>P<\/jats:italic> = 0.035). Neither frequency nor duration of surgical drainage placement differed significantly between the two groups. The overall complication rate in both groups was low without a statistically significant difference.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>An optimal interdisciplinary perioperative management provided the surgical treatment of fractures in <jats:styled-content style=\"fixed-case\">PWH<\/jats:styled-content> can be performed safely with a low complication rate.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hae.12803","type":"journal-article","created":{"date-parts":[[2015,10,10]],"date-time":"2015-10-10T09:31:54Z","timestamp":1444469514000},"source":"Crossref","is-referenced-by-count":6,"title":["Perioperative management and outcome of fracture treatment in patients with haemophilia without inhibitors"],"prefix":"10.1111","volume":"22","author":[{"given":"A. C.","family":"Strauss","sequence":"first","affiliation":[{"name":"Department of Orthopaedics and Trauma Surgery University of Bonn Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. H.","family":"Pennekamp","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Trauma Surgery University of Bonn Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Placzek","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Trauma Surgery University of Bonn Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Schmolders","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Trauma Surgery University of Bonn Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. J.","family":"Friedrich","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Trauma Surgery University of Bonn Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Oldenburg","sequence":"additional","affiliation":[{"name":"Institute for Experimental Haematology and Transfusion Medicine University of Bonn Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Burger","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Trauma Surgery University of Bonn Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. C.","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Trauma Surgery University of Bonn Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,10,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-194811000-00002"},{"key":"e_1_2_8_3_1","first-page":"111","article-title":"Moynihan Lecture, 1980. Major surgery in haemophilia","volume":"63","author":"Rudowski WJ","year":"1981","journal-title":"Ann R Coll Surg Engl"},{"key":"e_1_2_8_4_1","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1302\/0301-620X.50B2.351","article-title":"The management of fractures in haemophilia and Christmas disease","volume":"50","author":"Kemp HS","year":"1968","journal-title":"J Bone Joint Surg Br"},{"key":"e_1_2_8_5_1","first-page":"42","article-title":"Fluid and blood therapy in trauma","volume":"18","author":"Novikov MD","year":"2008","journal-title":"Int Trauma Care (ITACCS)"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2007.01448.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2007.01460.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02585724"},{"key":"e_1_2_8_9_1","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1542\/peds.70.3.431","article-title":"Management of fractures in hemophilia","volume":"70","author":"Wolff LJ","year":"1982","journal-title":"Pediatrics"},{"key":"e_1_2_8_10_1","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1097\/00003086-198005000-00035","article-title":"Fractures and dislocations in hemophilia","volume":"148","author":"Boardman KP","year":"1980","journal-title":"Clin Orthop Relat Res"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12538"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13312"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12512"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminhematol.2005.11.024"},{"key":"e_1_2_8_15_1","first-page":"154","article-title":"General surgery in adult hemophiliacs","volume":"99","author":"Brown B","year":"1986","journal-title":"Surgery"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2008.01742.x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2009.02.018"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-012-0988-9"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12392"},{"key":"e_1_2_8_20_1","first-page":"181","article-title":"Association of severe haemophilia A with osteoporosis: a densitometric and biochemical study","volume":"87","author":"Gallacher SJ","year":"1994","journal-title":"Q J Med"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2006.01405.x"},{"key":"e_1_2_8_22_1","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1177\/000313480407000914","article-title":"Cholecystectomy and acquired factor VIII inhibitor coagulopathy","volume":"70","author":"Walsh JD","year":"2004","journal-title":"Am Surg"},{"key":"e_1_2_8_23_1","first-page":"CD001886","article-title":"Anti\u2010fibrinolytic use for minimising perioperative allogeneic blood transfusion","volume":"16","author":"Henry DA","year":"2011","journal-title":"Cochrane Database Syst Rev"}],"container-title":["Haemophilia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhae.12803","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hae.12803","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T09:26:36Z","timestamp":1695547596000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hae.12803"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,9]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["10.1111\/hae.12803"],"URL":"https:\/\/doi.org\/10.1111\/hae.12803","archive":["Portico"],"relation":{},"ISSN":["1351-8216","1365-2516"],"issn-type":[{"value":"1351-8216","type":"print"},{"value":"1365-2516","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,9]]}}}