{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T15:42:07Z","timestamp":1762875727680},"reference-count":14,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,11,11]],"date-time":"2015-11-11T00:00:00Z","timestamp":1447200000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>The optimum mode of delivery in a known carrier of a haemophilia A is still an issue of debate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>This study was conducted to report a multicentre experience in Gulf Cooperation Council (<jats:styled-content style=\"fixed-case\">GCC<\/jats:styled-content>) on the incidence of intracranial haemorrhage (<jats:styled-content style=\"fixed-case\">ICH<\/jats:styled-content>) in newborns with severe haemophilia A delivered by different modalities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We have conducted a retrospective\/prospective multicentre cohort study including a total of seven hospitals distributed in four <jats:styled-content style=\"fixed-case\">GCC<\/jats:styled-content> countries between 1998 and Jan 2015. A total of 163 patient with severe haemophilia A (factor <jats:styled-content style=\"fixed-case\">VIII<\/jats:styled-content> &lt;1%) were enrolled in this study, age ranged between 2 weeks to 18 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Most of the patients were born by spontaneous vaginal delivery (<jats:styled-content style=\"fixed-case\">SVD<\/jats:styled-content>) (131, 80.4%), whereas 26 patients (16%) were born by <jats:styled-content style=\"fixed-case\">CS<\/jats:styled-content> and only six patients were born by instrumental delivery (3.7%), five of them by vacuum and one was delivered using forceps. Five out of 163 patients developed <jats:styled-content style=\"fixed-case\">ICH<\/jats:styled-content> during the first 2 weeks of life (3.1%). Two of them were born by <jats:styled-content style=\"fixed-case\">SVD<\/jats:styled-content> (2\/131; 1.5%) and two were born by instrumental delivery (2\/6; 33.3%). Only one patient among those who were born by caesarean section developed <jats:styled-content style=\"fixed-case\">ICH<\/jats:styled-content> (1\/26; 3.8%). Assisted vaginal delivery was associated with a significant risk of <jats:styled-content style=\"fixed-case\">ICH<\/jats:styled-content>, in comparison to <jats:styled-content style=\"fixed-case\">SVD<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">CS<\/jats:styled-content> (<jats:italic>P<\/jats:italic> = 0.0093).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Normal vaginal delivery is still considered a safe journey through the birth canal for haemophilic newborns particularly in this area of the world. Larger prospective studies might be needed to define an evidence\u2010based optimal mode of delivery for the haemophilia carrier expecting an affected child.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hae.12842","type":"journal-article","created":{"date-parts":[[2015,11,12]],"date-time":"2015-11-12T00:20:45Z","timestamp":1447287645000},"source":"Crossref","is-referenced-by-count":8,"title":["Mode of delivery and risk of intracranial haemorrhage in newborns with severe haemophilia A: a multicentre study in Gulf region"],"prefix":"10.1111","volume":"22","author":[{"given":"H. F.","family":"Nazir","sequence":"first","affiliation":[{"name":"Child Health Department Sultan Qaboos University Hospital Muscat Oman"},{"name":"Division of Hematology Department of Pediatrics Faculty of Medicine Alexandria University Alexandria Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Al Lawati","sequence":"additional","affiliation":[{"name":"Child Health Department Sultan Qaboos University Hospital Muscat Oman"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Beshlawi","sequence":"additional","affiliation":[{"name":"Child Health Department Sultan Qaboos University Hospital Muscat Oman"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"AlSharidah","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Mubarak Alkabeer Hospital Kuwait Kuwait"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Elshinawy","sequence":"additional","affiliation":[{"name":"Child Health Department Sultan Qaboos University Hospital Muscat Oman"},{"name":"Division of Hematology Department of Pediatrics Faculty of Medicine Alexandria University Alexandria Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Alkasim","sequence":"additional","affiliation":[{"name":"Pediatric Hematology Department Children Hospital King Saud Medical City Riyadh Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. F.","family":"Khanani","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Tawam Hospital Alain UAE"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Tarawa","sequence":"additional","affiliation":[{"name":"Hereditary Blood Disorders Center King Abdullah Medical City Madinah Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Al Subhi","sequence":"additional","affiliation":[{"name":"Child Health Department Sultan Qaboos University Hospital Muscat Oman"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Alrawas","sequence":"additional","affiliation":[{"name":"Child Health Department Sultan Qaboos University Hospital Muscat Oman"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Al Riyami","sequence":"additional","affiliation":[{"name":"Child Health Department Sultan Qaboos University Hospital Muscat Oman"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Al Kindi","sequence":"additional","affiliation":[{"name":"Child Health Department Sultan Qaboos University Hospital Muscat Oman"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Al Saadi","sequence":"additional","affiliation":[{"name":"Radiology Department Diwan Medical Complex Muscat Oman"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Al\u2010Lamki","sequence":"additional","affiliation":[{"name":"Department of Haematology &amp; Transfusion Medicine Royal Hospital Muscat Oman"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Wali","sequence":"additional","affiliation":[{"name":"Child Health Department Sultan Qaboos University Hospital Muscat Oman"},{"name":"Division of Hematology Department of Pediatrics Faculty of Medicine Alexandria University Alexandria Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,11,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2007.06949.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-199907000-00009"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2003.12.016"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2009.02142.x"},{"key":"e_1_2_8_6_1","first-page":"461","article-title":"A consensus statement on the management of pregnancy and delivery in women who are carriers of or have bleeding disorders","volume":"191","author":"Dunkley SM","year":"2009","journal-title":"MJA"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/heapol\/czh012"},{"key":"e_1_2_8_8_1","first-page":"7","volume-title":"Annual Health Report 2009","author":"Ministry of Health","year":"2010"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2007.01492.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1994.tb13090.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/PL00014346"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199912023412301"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2010.02316.x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2013.195"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2007.01561.x"}],"container-title":["Haemophilia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhae.12842","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hae.12842","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/hae.12842","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hae.12842","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T16:57:04Z","timestamp":1693414624000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hae.12842"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11,11]]},"references-count":14,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,5]]}},"alternative-id":["10.1111\/hae.12842"],"URL":"https:\/\/doi.org\/10.1111\/hae.12842","archive":["Portico"],"relation":{},"ISSN":["1351-8216","1365-2516"],"issn-type":[{"value":"1351-8216","type":"print"},{"value":"1365-2516","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11,11]]}}}