{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T02:36:18Z","timestamp":1787798178341,"version":"build-2784847793"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,12,16]],"date-time":"2015-12-16T00:00:00Z","timestamp":1450224000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000801","name":"Bayer HealthCare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000801","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:sec><jats:title>Background and objectives<\/jats:title><jats:p>This cross\u2010sectional, epidemiological study sought to assess the prevalence and extent of potential risk factors for hypertension, particularly renal function related to haematuria and their associations in people with haemophilia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methodology<\/jats:title><jats:p>Demographic and medical data were collected at a single time\u2010point in patients with haemophilia over 40 years of age from 16 European centres. Associations with diagnosis of hypertension were tested in univariate and multivariate analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We enrolled 532 patients (median age 52 years, range 40\u201398) with haemophilia A (<jats:italic>n<\/jats:italic> = 467) or haemophilia B (<jats:italic>n<\/jats:italic> = 65). Haemophilia was severe (&lt;0.01 IU mL<jats:sup>\u22121<\/jats:sup>) in 313 patients (59%). Hypertension was diagnosed in 239 patients (45%). In multivariate analyses, age and body mass index (<jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>) were significantly and independently associated with hypertension (adjusted odds ratio (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>) 18.1, <jats:italic>P<\/jats:italic> &lt; 0.001, in elderly patients and <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> = 25.1, <jats:italic>P<\/jats:italic> &lt; 0.001, in patients with <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> &gt;30 kg m<jats:sup>\u22122<\/jats:sup>). Estimated glomerular filtration rate (<jats:styled-content style=\"fixed-case\">eGFR<\/jats:styled-content>) &lt;70 mL min<jats:sup>\u22121<\/jats:sup> (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> = 2.7, <jats:italic>P<\/jats:italic> = 0.047) was significantly associated with hypertension, but mean <jats:styled-content style=\"fixed-case\">eGFR<\/jats:styled-content> was significantly higher for severe than mild haemophilia. Further variables with <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> &gt; 2.8 were diabetes (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> = 2.8, <jats:italic>P<\/jats:italic> = 0.04), coronary artery disease (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> = 3.3, <jats:italic>P<\/jats:italic> = 0.052) and family history of hypertension (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> = 4.4, <jats:italic>P<\/jats:italic> &lt; 0.001). Neither severity of haemophilia nor history of haematuria was significantly associated with hypertension in univariate or multivariate analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>As in the general population, age and <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> were major risk factors for hypertension in people with haemophilia. Renal dysfunction was associated with hypertension, but the prevalence of renal dysfunction was not extensive and furthermore not significantly correlated with haematuria. The associations of other variables with hypertension require further studies to confirm causal relationships over time.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hae.12847","type":"journal-article","created":{"date-parts":[[2015,12,16]],"date-time":"2015-12-16T06:46:39Z","timestamp":1450248399000},"page":"248-255","source":"Crossref","is-referenced-by-count":43,"title":["Hypertension, haematuria and renal functioning in haemophilia \u2013 a cross\u2010sectional study in Europe"],"prefix":"10.1111","volume":"22","author":[{"given":"P. A.","family":"Holme","sequence":"first","affiliation":[{"name":"Department of Haematology Oslo University Hospital and Institute of Clinical Medicine University of Oslo Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Combescure","sequence":"additional","affiliation":[{"name":"University Hospital and Faculty of Medicine of Geneva Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.C.","family":"Tait","sequence":"additional","affiliation":[{"name":"Royal Infirmary Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Berntorp","sequence":"additional","affiliation":[{"name":"Lund University Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Rauchensteiner","sequence":"additional","affiliation":[{"name":"Bayer Healthcare Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"de Moerloose","sequence":"additional","affiliation":[{"name":"University Hospital and Faculty of Medicine of Geneva Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the ADVANCE Working Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,12,16]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2009.03669.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/107602960601200207"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1990.tb07793.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH10-07-0460"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2008.02929.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-198002000-00011"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2009.03318.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MBC.0b013e328345f582"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH12-05-0313"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.113.01174"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2014.12.027"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht151"},{"key":"e_1_2_8_14_1","unstructured":"Centers for Disease Control.End\u2010stage renal disease patients by selected characteristics: United States selected years 1980\u20132010: table 51. Health United States2011web updates. Available atwww.cdc.gov\/nchs\/data\/hus\/2011\/051.pdf. Accessed December 16 2014."},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40292-013-0023-2"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pop.2014.08.001"},{"key":"e_1_2_8_17_1","first-page":"437","article-title":"Mortality among males with haemophilia: relations with source of medical care. The Haemophilia Surveillance System Project Investigators","volume":"96","author":"Soucie JM","year":"2000","journal-title":"Blood"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1351-8216.2003.00821.x"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.12672"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1159\/000180580"},{"key":"e_1_2_8_21_1","unstructured":"R Foundation for Statistical Computing Vienna Austria. Availabale athttp:\/\/www.R-project.org\/. Accessed 27 October 2015."},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-7435(87)90087-9"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/MBC.0b013e328352cafc"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00103-013-1669-6"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2006.03.017"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)11911-8"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2007.06949.x"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2011.02611.x"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH12-05-0332"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2011.12.012"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2009.02030.x"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2010.02463.x"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2008.01806.x"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12279"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2010.02477.x"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2007.01445.x"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0609.2003.00077.x"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2009.02171.x"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e3283310dc9"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12472"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12339"}],"container-title":["Haemophilia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhae.12847","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hae.12847","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T13:14:55Z","timestamp":1695561295000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hae.12847"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12,16]]},"references-count":40,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,3]]}},"alternative-id":["10.1111\/hae.12847"],"URL":"https:\/\/doi.org\/10.1111\/hae.12847","archive":["Portico"],"relation":{},"ISSN":["1351-8216","1365-2516"],"issn-type":[{"value":"1351-8216","type":"print"},{"value":"1365-2516","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12,16]]}}}