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However, the development of factor <jats:styled-content style=\"fixed-case\">VIII<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">FVIII<\/jats:styled-content>) inhibitors is the greatest complication of the disease and a challenge in the treatment of haemophilia making management of bleeding episodes difficult and surgical procedures very challenging. A meeting to discuss the unmet needs of haemophilia patients with inhibitors was held in Paris on 20 November 2014. Topics discussed were genetic and non\u2010genetic risk factors for the development of inhibitors, immunological aspects of inhibitor development, <jats:styled-content style=\"fixed-case\">FVIII<\/jats:styled-content> products and inhibitor development, generation and functional properties of engineered antigen\u2010specific T regulatory cells, suppression of immune responses to <jats:styled-content style=\"fixed-case\">FVIII<\/jats:styled-content>, prophylaxis in haemophilia patients with inhibitors, epitope mapping of <jats:styled-content style=\"fixed-case\">FVIII<\/jats:styled-content> inhibitors, current controversies in immune tolerance induction therapy, surgery in haemophilia patients with inhibitors and future perspectives for the treatment of haemophilia patients with inhibitors. A summary of the key points discussed is presented in this paper.<\/jats:p>","DOI":"10.1111\/hae.12860","type":"journal-article","created":{"date-parts":[[2016,1,5]],"date-time":"2016-01-05T08:42:53Z","timestamp":1451983373000},"page":"1-24","source":"Crossref","is-referenced-by-count":17,"title":["Achievements, challenges and unmet needs for haemophilia patients with inhibitors"],"prefix":"10.1111","volume":"22","author":[{"given":"Y.","family":"Dargaud","sequence":"first","affiliation":[{"name":"Unite d'Hemostase Clinique Hopital Cardiologique Louis Pradel Universite Lyon 1 Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Pavlova","sequence":"additional","affiliation":[{"name":"Institute of Experimental Haematology and Transfusion Medicine University Clinic Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Lacroix\u2010Desmazes","sequence":"additional","affiliation":[{"name":"INSERM UMRS 1138 Immunopathologie et immuno\u2010intervention th\u00e9rapeutique Centre de Recherche des Cordeliers Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Fischer","sequence":"additional","affiliation":[{"name":"Van Creveldkliniek (HP C01.425) University Medical Center Utrecht Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Soucie","sequence":"additional","affiliation":[{"name":"Division of Blood Disorders National Center for Birth Defects and Developmental Disabilities Centers for Disease Control and Prevention Atlanta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Claeyssens","sequence":"additional","affiliation":[{"name":"Chu Purpan Pav. 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