{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T22:57:38Z","timestamp":1789685858285,"version":"4.0.1"},"reference-count":52,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,7,21]],"date-time":"2016-07-21T00:00:00Z","timestamp":1469059200000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2016,7]]},"abstract":"\n Introduction<\/jats:title>\n \n People with haemophilia (\n PWH<\/jats:styled-content>\n ) experience end stage joint disease as a result of repeated hemarthrosis, commonly leading to total knee arthroplasty (\n TKA<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Aim<\/jats:title>\n \n The goal of this meta\u2010analysis is to calculate expected outcomes for range of motion (\n ROM<\/jats:styled-content>\n ), functional mobility, and complication rates in\n PWH<\/jats:styled-content>\n following\n TKA<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Studies published between 1980 and 2015 were identified. Inclusion criteria:\n PWH<\/jats:styled-content>\n having\n TKA<\/jats:styled-content>\n , reporting Hospital for Special Surgery Knee Score or Knee Society Score, knee\n ROM<\/jats:styled-content>\n , and incidence of complications for more than 5\n TKA<\/jats:styled-content>\n s. Inhibitor status, haemophilia severity and\n HIV<\/jats:styled-content>\n status were not criteria for inclusion or exclusion. Meta\u2010analysis was performed using mean, standard deviation, or\n P<\/jats:italic>\n \u2010value data to create effect sizes (\n ES<\/jats:styled-content>\n ) and 95% confidence intervals for each variable.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Twenty studies met inclusion criteria; ten had sufficient data for meta\u2010analyses. A total of 336\n TKA<\/jats:styled-content>\n s in 254\n PWH<\/jats:styled-content>\n were analysed with mean follow\u2010up of 6.3\u00a0years. Statistically significant\n ROM<\/jats:styled-content>\n improvements were found with 9.72\u00b0 improvement of flexion contracture (\u22120.73 effect size (ES) (\u22120.91 to \u22120.56)), and 15.69\u00b0increase into flexion (0.63\n ES<\/jats:styled-content>\n (0.34\u20130.91)). Knee scores showed statistically significant improvements: clinically, 37.9 point increase (3.21\n ES<\/jats:styled-content>\n [1.79\u20134.63]) and functionally, 13.50 point increase (1.50\n ES<\/jats:styled-content>\n [0.80\u20132.21]). A 31.5% complication rate was calculated with 106 reported in 336\n TKA<\/jats:styled-content>\n s.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n TKA<\/jats:styled-content>\n is an effective procedure for improving\n ROM<\/jats:styled-content>\n and decreasing functional deficits resulting from haemophilic arthropathy. Knee score data shows\n TKA<\/jats:styled-content>\n improves overall function. This study guides clinicians regarding outcome expectations post\u2010\n TKA<\/jats:styled-content>\n in\n PWH<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/hae.12885","type":"journal-article","created":{"date-parts":[[2016,7,22]],"date-time":"2016-07-22T00:26:24Z","timestamp":1469147184000},"source":"Crossref","is-referenced-by-count":57,"title":["Meta\u2010analysis: outcomes of total knee arthroplasty in the haemophilia population"],"prefix":"10.1111","volume":"22","author":[{"given":"M. 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