{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T09:33:58Z","timestamp":1768296838861,"version":"3.49.0"},"reference-count":127,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,3,29]],"date-time":"2016-03-29T00:00:00Z","timestamp":1459209600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>In haemophilia, the ankle joint is one of the most common and earliest joints affected by recurrent bleeding, commonly resulting in end\u2010stage ankle osteoarthritis during early adulthood. The surgical treatment of haemophilic ankle arthropathy is challenging.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>This review aims to highlight the literature addressing clinical outcomes following the most common approaches for different stages of haemophilia\u2010induced ankle osteoarthritis: arthroscopic debridement, joint distraction arthroplasty, supramalleolar osteotomies, total ankle replacement, and ankle arthrodesis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A systematic literature review was performed using established medical literature databases. The following information was retrieved from the literature: patients\u2019 demographics, surgical technique, duration of follow\u2010up, clinical outcome including pain relief and complication rate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 42 clinical studies published between 1978 and 2015 were included in the systematic literature review. Eight and 34 studies had prospective and retrospective design, respectively. The most common studies were level<jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>studies (64.3%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>The orthopaedic treatment of patients with haemophilic ankle osteoarthritis is often challenging and requires complete and careful preoperative assessment. In general, both joint\u2010preserving and joint non\u2010preserving procedure types can be performed. All specific relative and absolute contraindications should be considered to achieve appropriate postoperative outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The current literature demonstrated that orthopaedic surgeries, with appropriate indication, in patients with haemophilic ankle arthropathy result in good postoperative results comparable to those observed in non\u2010haemophiliacs. The surgical treatment should be performed in a setting with the ability to have multidisciplinary management, including expertise in haematology.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hae.12919","type":"journal-article","created":{"date-parts":[[2016,3,31]],"date-time":"2016-03-31T21:58:10Z","timestamp":1459461490000},"source":"Crossref","is-referenced-by-count":18,"title":["Surgical procedures in patients with haemophilic arthropathy of the ankle"],"prefix":"10.1111","volume":"22","author":[{"given":"A.","family":"Barg","sequence":"first","affiliation":[{"name":"Department of Orthopaedics University of Utah Salt Lake City UT USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. C.","family":"Morris","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics University of Utah Salt Lake City UT USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. W.","family":"Schneider","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venerology, and Allergology University Medical Center and Medical Faculty Mannheim University of Heidelberg Mannheim Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Phisitkul","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Rehabilitation University of Iowa Iowa City IA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. L.","family":"Saltzman","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics University of Utah Salt Lake City UT USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,3,29]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2008.01734.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2010.02433.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.5435\/00124635-200407000-00004"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.1999.t01-1-00291.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2008.01720.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2006.01285.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.2000.00397.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12748"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2011.02567.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2006.01203.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.2002.00680.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.2001.00540.x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12320"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12779"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.1999.00287.x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-199173070-00007"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2005.01133.x"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2011.02544.x"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jfas.2012.06.005"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12323"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1586\/17474086.2015.1087846"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.L.00046"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2008.01820.x"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2007.01539.x"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.2002.00606.x"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1159\/000208851"},{"key":"e_1_2_8_28_1","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1111\/j.1600-0609.1984.tb02573.x","article-title":"Arthroscopic synovectomy in the treatment of hemophilic synovitis","volume":"40","author":"Kim HC","year":"1984","journal-title":"Scand J Haematol Suppl"},{"key":"e_1_2_8_29_1","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1111\/j.1600-0609.1984.tb02572.x","article-title":"Arthroscopic synovectomy in hemophilic arthropathy of the knee","volume":"40","author":"Wiedel JD","year":"1984","journal-title":"Scand J Haematol Suppl"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0749-8063(96)90165-6"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-199308000-00016"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.K.00069"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1177\/1947603515574286"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/01241398-200407000-00013"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-200309000-00010"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jfas.2007.03.008"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/MBC.0000000000000230"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2009.01982.x"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-199406000-00004"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12704"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fcl.2013.06.005"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2011.02.005"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1053\/joca.1999.0263"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.N.00901"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.K.00018"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2012.02805.x"},{"key":"e_1_2_8_47_1","first-page":"e539","article-title":"First prospective results of joint\u00a0distraction in severe haemophilic ankle arthropathy","volume":"21","author":"Van Vulpen LFD","year":"2015","journal-title":"Haemophilia"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00264-013-2030-2"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12178-014-9231-1"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fcl.2012.08.007"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fcl.2012.09.002"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.76B6.7983125"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12583"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1097\/BLO.0b013e318124a462"},{"key":"e_1_2_8_55_1","first-page":"1078","volume-title":"Mann's Surgery of the Foot and Ankle","author":"Barg A","year":"2014"},{"key":"e_1_2_8_56_1","first-page":"177","article-title":"Total ankle replacement \u2013 indications, implant designs, and results","volume":"112","author":"Barg A","year":"2015","journal-title":"Dtsch Arztebl Int"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-009-0987-3"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.95B11.31633"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.3113\/FAI.2009.0579"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.3113\/FAI.2008.0978"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1177\/107110070302400612"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.3113\/FAI.2010.0754"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.3113\/FAI.2009.0783"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fcl.2013.06.001"},{"key":"e_1_2_8_65_1","first-page":"44","article-title":"Epidemiology of ankle arthritis: report of a consecutive series of 639 patients from a tertiary orthopaedic center","volume":"25","author":"Saltzman CL","year":"2005","journal-title":"Iowa Orthop J"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fas.2014.08.004"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2010.02221.x"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00132-015-3107-y"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12561"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1621497"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13104-015-1763-y"},{"key":"e_1_2_8_72_1","first-page":"383","article-title":"Our experience of ankle arthroplasty in haemophiliac patients","volume":"6","author":"Duboullay CH","year":"2000","journal-title":"Haemophilia"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12673"},{"key":"e_1_2_8_74_1","first-page":"80","article-title":"Ankle prosthesis in patients with severe haemophilic arthropathy","volume":"14","author":"Krause M","year":"2008","journal-title":"Haemophilia"},{"key":"e_1_2_8_75_1","first-page":"122","article-title":"Results of ankle prosthesis in patients with severe hemophilic arthropathy: follow\u2010up","volume":"18","author":"Krause M","year":"2012","journal-title":"Haemophilia"},{"key":"e_1_2_8_76_1","first-page":"428","article-title":"[Study on short\u2010term effects of ankle replacement for the treatment of hemophilic arthritis]","volume":"22","author":"Min ZH","year":"2009","journal-title":"Zhongguo Gu Shang"},{"key":"e_1_2_8_77_1","first-page":"54","article-title":"Ankle prosthesis as the treatment of choice in haemophilic arthropathy","volume":"12","author":"Polack B","year":"2006","journal-title":"Haemophilia"},{"key":"e_1_2_8_78_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2008.01650.x"},{"key":"e_1_2_8_79_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1617114"},{"key":"e_1_2_8_80_1","first-page":"e537","article-title":"Total ankle replacement in hemophilic patients: a single centre experience","volume":"21","author":"Solimeno LP","year":"2015","journal-title":"Haemophilia"},{"key":"e_1_2_8_81_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12392"},{"key":"e_1_2_8_82_1","first-page":"383","article-title":"Total ankle arthroplasty for haemophilic arthropathy more than 10\u00a0years of postoperative follow\u2010up","volume":"6","author":"Takedani H","year":"2000","journal-title":"Haemophilia"},{"key":"e_1_2_8_83_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2006.01350.x"},{"key":"e_1_2_8_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amsu.2015.09.003"},{"key":"e_1_2_8_85_1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1097\/00003086-199003000-00031","article-title":"Ankle arthroplasty. A comparative study of cemented metal and uncemented ceramic prostheses","volume":"252","author":"Takakura Y","year":"1990","journal-title":"Clin Orthop Relat Res"},{"key":"e_1_2_8_86_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.93B3.25467"},{"key":"e_1_2_8_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fcl.2008.04.007"},{"key":"e_1_2_8_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fas.2007.08.004"},{"key":"e_1_2_8_89_1","first-page":"726","article-title":"Einige Falle kunstlicher Ankylosen: Bildung an paralytischen Gliedmassen","volume":"23","author":"Albert E","year":"1882","journal-title":"Wien Med Press"},{"key":"e_1_2_8_90_1","doi-asserted-by":"publisher","DOI":"10.3113\/FAI.2009.0187"},{"key":"e_1_2_8_91_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-200102000-00009"},{"key":"e_1_2_8_92_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.85B7.13984"},{"key":"e_1_2_8_93_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12114"},{"key":"e_1_2_8_94_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2010.02248.x"},{"key":"e_1_2_8_95_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.F.01611"},{"key":"e_1_2_8_96_1","doi-asserted-by":"publisher","DOI":"10.1177\/1071100715584014"},{"key":"e_1_2_8_97_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.60B3.681415"},{"key":"e_1_2_8_98_1","doi-asserted-by":"publisher","DOI":"10.1177\/1071100713481775"},{"key":"e_1_2_8_99_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12308"},{"key":"e_1_2_8_100_1","first-page":"382","article-title":"Talocrural arthrodesis in haemophilia","volume":"6","author":"Crewe BJ","year":"2000","journal-title":"Haemophilia"},{"key":"e_1_2_8_101_1","first-page":"116","article-title":"Arthroscopic ankle arthrodesis for hemophilic arthropathy","volume":"18","author":"Inagaki Y","year":"2012","journal-title":"Haemophilia"},{"key":"e_1_2_8_102_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12398"},{"key":"e_1_2_8_103_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2008.01651.x"},{"key":"e_1_2_8_104_1","first-page":"64","article-title":"Ankle fusion in hemophilia","volume":"12","author":"Silva M","year":"2006","journal-title":"Haemophilia"},{"key":"e_1_2_8_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foot.2011.01.001"},{"key":"e_1_2_8_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(74)90884-8"},{"key":"e_1_2_8_107_1","doi-asserted-by":"publisher","DOI":"10.3113\/FAI.2009.0690"},{"key":"e_1_2_8_108_1","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1097\/00003086-198510000-00010","article-title":"Measurement of the motion range in the loaded ankle","volume":"199","author":"Lindsjo U","year":"1985","journal-title":"Clin Orthop Relat Res"},{"key":"e_1_2_8_109_1","doi-asserted-by":"publisher","DOI":"10.3113\/FAI.2012.0655"},{"key":"e_1_2_8_110_1","doi-asserted-by":"publisher","DOI":"10.1177\/107110079501600911"},{"key":"e_1_2_8_111_1","doi-asserted-by":"publisher","DOI":"10.1177\/1071100715591091"},{"key":"e_1_2_8_112_1","doi-asserted-by":"publisher","DOI":"10.1177\/107110070602700808"},{"key":"e_1_2_8_113_1","first-page":"37","article-title":"\u201cNormal\u201d talar tilt angle","volume":"140","author":"Cox JS","year":"1979","journal-title":"Clin Orthop Relat Res"},{"key":"e_1_2_8_114_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-014-3960-8"},{"key":"e_1_2_8_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2014.11.010"},{"key":"e_1_2_8_116_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.16.4.494"},{"key":"e_1_2_8_117_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-198006000-00018"},{"key":"e_1_2_8_118_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.J.00249"},{"key":"e_1_2_8_119_1","doi-asserted-by":"publisher","DOI":"10.1097\/BTF.0b013e31829337b8"},{"key":"e_1_2_8_120_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2012.02835.x"},{"key":"e_1_2_8_121_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12375"},{"key":"e_1_2_8_122_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2007.01533.x"},{"key":"e_1_2_8_123_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2006.01268.x"},{"key":"e_1_2_8_124_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fas.2013.12.003"},{"key":"e_1_2_8_125_1","doi-asserted-by":"publisher","DOI":"10.3109\/17453674.2015.1056701"},{"key":"e_1_2_8_126_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.L.00538"},{"key":"e_1_2_8_127_1","doi-asserted-by":"publisher","DOI":"10.3109\/17453674.2015.1009673"},{"key":"e_1_2_8_128_1","doi-asserted-by":"publisher","DOI":"10.1177\/1071100714559272"}],"container-title":["Haemophilia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhae.12919","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hae.12919","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/hae.12919","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hae.12919","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,15]],"date-time":"2024-06-15T11:43:51Z","timestamp":1718451831000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hae.12919"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,29]]},"references-count":127,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,5]]}},"alternative-id":["10.1111\/hae.12919"],"URL":"https:\/\/doi.org\/10.1111\/hae.12919","archive":["Portico"],"relation":{},"ISSN":["1351-8216","1365-2516"],"issn-type":[{"value":"1351-8216","type":"print"},{"value":"1365-2516","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,29]]}}}