{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T13:05:55Z","timestamp":1768568755199,"version":"3.49.0"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,7,25]],"date-time":"2016-07-25T00:00:00Z","timestamp":1469404800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008616","name":"Rush University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008616","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>The prophylactic administration of clotting factor concentrate is currently the most effective strategy for the prevention of joint bleeding. As new agents with different mechanisms of action and administration schedules are developed, it will be important to study them in relevant preclinical models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of this study was the standardization of a mouse haemarthrosis model in a haemophilia mouse and the development and validation of a comprehensive bleeding assessment system, the Bleeding Severity Score (<jats:styled-content style=\"fixed-case\">BSS<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>Four outcome measurements were assessed, two of which, the extra\u2010articular bleeding score and intra\u2010articular bleeding score, were determined to be the most reliable and were summarized into a <jats:styled-content style=\"fixed-case\">BSS<\/jats:styled-content> which was validated using a mouse haemarthrosis variability model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Using this model, the haemostatic effect of prospective drugs can be assessed in a clinically relevant joint bleeding model and will significantly increase the value of preclinical studies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hae.12950","type":"journal-article","created":{"date-parts":[[2016,7,26]],"date-time":"2016-07-26T03:13:33Z","timestamp":1469502813000},"page":"790-798","source":"Crossref","is-referenced-by-count":7,"title":["Haemarthrosis model in mice: <scp>BSS<\/scp> \u2013 Bleeding Severity Score assessment system"],"prefix":"10.1111","volume":"22","author":[{"given":"N.","family":"Hakobyan","sequence":"first","affiliation":[{"name":"Department of Pediatrics Rush University Medical Center Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. 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Q.","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Rush University Medical Center Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Desai","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Rush University Medical Center Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Radtke","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Rush University Medical Center Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. F.","family":"Fogg","sequence":"additional","affiliation":[{"name":"Rush College of Nursing Rush University Medical Center Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,7,25]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2011.02615.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-197759030-00001"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1586\/ehm.12.27"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2011.04214.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2010.02435.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.1994.tb00815.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa067659"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.12202"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2011.04611.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2008.03270.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1182\/blood.V58.5.868.868","article-title":"Hemophilic dog model for evaluating therapeutic effectiveness of plasma protein fractions","volume":"58","author":"Kingdon HS","year":"1981","journal-title":"Blood"},{"key":"e_1_2_8_13_1","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1055\/s-0038-1661450","article-title":"Evaluation of the cuticle bleeding time in canine haemophilia A","volume":"55","author":"Pijnappels MI","year":"1986","journal-title":"Thromb Haemost"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001721-199507000-00004"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1615666"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2012.02780.x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2006.01208.x"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000183884.06371.52"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0595-119"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V88.9.3446.bloodjournal8893446"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2008.01689.x"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2004.00899.x"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12532"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1037\/0033-2909.83.5.762"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)90837-8"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2003.11.031"}],"container-title":["Haemophilia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhae.12950","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hae.12950","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T23:27:29Z","timestamp":1694906849000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hae.12950"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,25]]},"references-count":25,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["10.1111\/hae.12950"],"URL":"https:\/\/doi.org\/10.1111\/hae.12950","archive":["Portico"],"relation":{},"ISSN":["1351-8216","1365-2516"],"issn-type":[{"value":"1351-8216","type":"print"},{"value":"1365-2516","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,25]]}}}