{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T02:42:57Z","timestamp":1792636977292,"version":"4.5.0"},"reference-count":31,"publisher":"Wiley","issue":"S5","license":[{"start":{"date-parts":[[2016,7,13]],"date-time":"2016-07-13T00:00:00Z","timestamp":1468368000000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:p>The State of the Art in von Willebrand disease (<jats:styled-content style=\"fixed-case\">VWD<\/jats:styled-content>) has been impacted not only by discoveries in the field of haemostasis, but also by changes in practice in other fields. The development of bleeding assessment tools has led to the clarification of bleeding symptoms and phenotype in <jats:styled-content style=\"fixed-case\">VWD<\/jats:styled-content>. New discoveries in the biology and genetics of von Willebrand factor (<jats:styled-content style=\"fixed-case\">VWF<\/jats:styled-content>) are challenging our existing diagnostics and classification(s). An improved understanding of reproductive physiology and the pathology of <jats:styled-content style=\"fixed-case\">VWD<\/jats:styled-content> along with changing obstetric, gynaecologic and haemostatic therapies necessitate an evolving response to the care of women with <jats:styled-content style=\"fixed-case\">VWD<\/jats:styled-content>. The survival of patients with autoimmune disease, malignancies and congenital heart disease along with increasing use of circulatory support devices and extracorporeal membrane oxygenation is increasing the prevalence of acquired von Willebrand syndrome. In each of these challenges, there are opportunities to improve the care of our patients with <jats:styled-content style=\"fixed-case\">VWD<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/hae.12984","type":"journal-article","created":{"date-parts":[[2016,7,13]],"date-time":"2016-07-13T09:32:50Z","timestamp":1468402370000},"page":"54-59","source":"Crossref","is-referenced-by-count":33,"title":["State of the art: von Willebrand disease"],"prefix":"10.1111","volume":"22","author":[{"given":"A. 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