{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T06:59:08Z","timestamp":1770447548021,"version":"3.49.0"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,7,11]],"date-time":"2016-07-11T00:00:00Z","timestamp":1468195200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Baxter Germany"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Physical activity is influenced by pain and vice versa. Although studies recommend exercise therapy for patients with haemophilia (PwH), the influence of physical activity on the pain condition in PwH has not been investigated so far.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>Aim of this study was to examine the effect of a treadmill intervention with self\u2010chosen velocity on the acute pain sensitivity in PwH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p>Twenty PwH [aged 24\u201358 years, moderate (<jats:italic>n<\/jats:italic> = 3) to severe (<jats:italic>n<\/jats:italic> = 17) haemophilia A (<jats:italic>n<\/jats:italic> = 17) or B (<jats:italic>n<\/jats:italic> = 3)] and 20 control subjects (aged 26\u201361 years) were included in this study. Eighteen PwH and all controls completed a treadmill intervention for 30 min. Pressure pain thresholds (<jats:styled-content style=\"fixed-case\">PPT<\/jats:styled-content>) in Newton (N) were measured at both the knees, ankles and elbows, sternum and forehead before (pre) and immediately after walking (post).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>PwH and controls walked with comparable speed (mean speed in km h<jats:sup>\u22121<\/jats:sup>; PwH: 3.5, controls: 3.8), resulting in significantly different values of performance\u2010related parameters such as heart rate (mean heart rate per minute; PwH: 102, controls: 86; <jats:italic>P<\/jats:italic> \u2264 0.01). Compared to baseline values, <jats:styled-content style=\"fixed-case\">PPT<\/jats:styled-content> remained unaltered at all landmarks in both groups after walking (e.g. pre\/post in Newton; knee right: PwH: 63.1\/63.0, controls: 93.8\/93.8; left knee: PwH: 62.1\/62.7, controls: 90.0\/93.4), indicating a non\u2010increasing pain condition.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Findings of unaltered <jats:styled-content style=\"fixed-case\">PPT<\/jats:styled-content> following moderate aerobic exercise showed initial evidence that PwH are able to perform an endurance exercise with self\u2010chosen velocity for 30 min as recommended, without increasing the acute pain condition. By doing so, PwH can benefit from the positive effects of endurance exercise.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hae.13016","type":"journal-article","created":{"date-parts":[[2016,7,11]],"date-time":"2016-07-11T05:26:39Z","timestamp":1468214799000},"page":"886-893","source":"Crossref","is-referenced-by-count":21,"title":["Pain sensitivity in patients with haemophilia following moderate aerobic exercise intervention"],"prefix":"10.1111","volume":"22","author":[{"given":"S.","family":"Kr\u00fcger","sequence":"first","affiliation":[{"name":"Department of Sports Medicine University of Wuppertal Wuppertal Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Weitz","sequence":"additional","affiliation":[{"name":"Department of Sports Medicine University of Wuppertal Wuppertal Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Runkel","sequence":"additional","affiliation":[{"name":"Department of Sports Medicine 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