{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T02:59:39Z","timestamp":1772074779257,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,9,19]],"date-time":"2016-09-19T00:00:00Z","timestamp":1474243200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000801","name":"Bayer HealthCare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000801","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Most previous joint imaging scales for haemophilia have focused on earlier disease stages observed in younger patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>We sought to demonstrate that the 45\u2010item extended magnetic resonance imaging (eMRI) scale is a valid instrument for measuring joint status in adults with severe haemophilia A.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Six scale categories (effusion\/haemarthrosis, synovial hypertrophy, hemosiderin, erosion, subchondral cysts and cartilage loss) in two domains (soft tissue [range = 0\u20139] and osteochondral [range = 0\u201336]) were evaluated for each joint. eMRI scores were derived using baseline data from a randomized, controlled, parallel\u2010group clinical trial (SPINART). Quantitative analysis of linearity included assessments of the relationship between scores derived from the eMRI scale vs. the 17\u2010point International Prophylaxis Study Group (IPSG) MRI scale and Colorado Adult Joint Assessment Scale (CAJAS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patient eMRI scores correlated with age (<jats:italic>r<\/jats:italic> = 0.58), consistent with the expectation of arthropathy progression and more severe joint changes in older patients. eMRI scores demonstrated excellent between\u2010reader agreement for overall patient score (intraclass correlation coefficient [ICC] = 0.88) and outstanding agreement for knee evaluations (ICC = 0.95). There was a strong linear relationship of the eMRI score with the CAJAS (<jats:italic>r<\/jats:italic> = 0.7). Adding individual bone evaluations for each joint increased the sensitivity of the instrument to detect change at low scores. There was minimal ceiling effect (5% maximum scores for all evaluated joints) compared with the IPSG MRI scale (20%). Internal reliability was good (overall Cronbach's alpha = 0.75).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Overall, the eMRI scale represents a valid and reliable measure of joint status in adolescents and adults with severe haemophilia A.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hae.13022","type":"journal-article","created":{"date-parts":[[2016,9,19]],"date-time":"2016-09-19T11:33:02Z","timestamp":1474284782000},"source":"Crossref","is-referenced-by-count":13,"title":["SPINART study: validation of the extended magnetic resonance imaging scale for evaluation of joint status in adult patients with severe haemophilia A using baseline data"],"prefix":"10.1111","volume":"22","author":[{"given":"W.","family":"Hong","sequence":"first","affiliation":[{"name":"Bayer Whippany NJ USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Raunig","sequence":"additional","affiliation":[{"name":"ICON Medical Imaging Warrington PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Lundin","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund University, Department of Diagnostic Radiology Lund Sweden"},{"name":"Center for Medical Imaging and Physiology Sk\u00e5ne University Hospital Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,9,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2010.03962.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.1994.tb00815.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.9.s1.10.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2012.02909.x"},{"key":"e_1_2_8_6_1","unstructured":"National Hemophilia Foundation.Medical and Scientific Advisory Council (MASAC) recommendations concerning prophylaxis (regular administration of clotting factor concentrate to prevent bleeding). Document #179. Available athttp:\/\/www.hemophilia.org\/sites\/default\/files\/document\/filesmasac179.pdf. 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