{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T15:11:10Z","timestamp":1779289870092,"version":"3.51.4"},"reference-count":58,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,8,3]],"date-time":"2016-08-03T00:00:00Z","timestamp":1470182400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100005614","name":"Biogen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005614","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction and Objectives<\/jats:title>\n                    <jats:p>Intra\u2010articular corticosteroid injections are standard of care for managing joint pain secondary to osteoarthritis or rheumatoid arthritis but are rarely used in haemophilic arthropathy. We have introduced and evaluated the efficacy and safety of ultrasound\u2010guided corticosteroid injections for pain relief in patients with haemophilic arthropathy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and methods<\/jats:title>\n                    <jats:p>\n                      Ultrasound\u2010guided intra\u2010articular injections performed on haemophilia patients at\n                      <jats:styled-content style=\"fixed-case\">UCSD<\/jats:styled-content>\n                      between March 2012 and January 2016 were analysed. Needle placement and injection (40 mg triamcinolone; 3\u20135\n                      <jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>\n                      lidocaine) were performed with musculoskeletal ultrasound and Power Doppler. Analysis included patient demographics, joint\u2010specific parameters such as tissue hypervascularity and effusions, pain relief, and procedure\u2010associated complications.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Forty\u2010five injections (14 ankles, 13 elbows, 18 knees) were administered in 25 patients. Advanced arthropathy with hypervascularity and\/or effusions was present in 91% and 61% of joints, respectively. Ninety\u2010one per cent of injections resulted in pain relief which was significant in 84% (&gt;30% reduction). Median pain score was reduced from 7 of 10 to 1 of 10 (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.001), usually within 24 h. Median duration of pain relief was 8 weeks (range 1\u201316 weeks). Haemophilia B patients experienced longer periods of relief, and high Pettersson scores were associated with shorter duration of relief. There were no procedure\u2010associated complications. Repeat ultrasound of eight joints within 4 weeks of injection demonstrated nearly complete resolution of hypervascularity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Point\u2010of\u2010care ultrasound enabled intra\u2010articular corticosteroid injections that provided highly effective, safe, and relatively long\u2010lasting pain relief in haemophilic arthropathy. This approach should be used to improve pain management in haemophilic arthropathy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hae.13057","type":"journal-article","created":{"date-parts":[[2016,8,3]],"date-time":"2016-08-03T11:13:41Z","timestamp":1470222821000},"page":"135-143","source":"Crossref","is-referenced-by-count":24,"title":["Efficacy and safety of point\u2010of\u2010care ultrasound\u2010guided intra\u2010articular corticosteroid joint injections in patients with haemophilic arthropathy"],"prefix":"10.1111","volume":"23","author":[{"given":"E. J.","family":"Martin","sequence":"first","affiliation":[{"name":"Division of Hematology\/Oncology Department of Medicine University of California San Diego San Diego CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. J.","family":"Cooke","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology Department of Medicine University of California San Diego San Diego CA USA"},{"name":"Department of Molecular and Experimental Medicine The Scripps Research Institute La Jolla CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Ceponis","sequence":"additional","affiliation":[{"name":"Division of Rheumatology Allergy and Immunology Department of Medicine University of California San Diego La Jolla CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. F. W.","family":"Barnes","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology Department of Medicine University of California San Diego San Diego CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. M.","family":"Moran","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology Department of Medicine University of California San Diego San Diego CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Holle","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology Department of Medicine University of California San Diego San Diego CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. H.","family":"Hughes","sequence":"additional","affiliation":[{"name":"Department of Radiology University of California San Diego San Diego CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. E.","family":"Moore","sequence":"additional","affiliation":[{"name":"General Musculoskeletal Imaging Inc Cincinnati OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"von Drygalski","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology Department of Medicine University of California San Diego San Diego CA USA"},{"name":"Department of Molecular and Experimental Medicine The Scripps Research Institute La Jolla CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,8,3]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminhematol.2015.10.005"},{"key":"e_1_2_9_3_1","first-page":"532","article-title":"Intraarticular prednisolone injection for osteoarthritis of the knee. A double blind test with placebo","volume":"132","author":"Cederlof S","year":"1966","journal-title":"Acta Chir Scand"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.21.2.188"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/19.4.212"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1951.03670340019005"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.10777"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.10148"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21596"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22087"},{"key":"e_1_2_9_11_1","first-page":"25","article-title":"Intraarticular dexamethasone in advanced chronic synovitis in hemophilia","volume":"343","author":"Fernandez\u2010Palazzi F","year":"1997","journal-title":"Clin Orthop Relat Res"},{"key":"e_1_2_9_12_1","first-page":"480","article-title":"Intra\u2010articular methylprednisolone therapy in chronic hemophilic synovitis of the knee","volume":"194","author":"Rodriguez\u2010Merchan EC","year":"1994","journal-title":"Rev Clin Esp"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830270107"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2010.02380.x"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12175"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.60.7.641"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH12-11-0874"},{"key":"e_1_2_9_18_1","first-page":"2485","article-title":"Musculoskeletal ultrasound including definitions for ultrasonographic pathology","volume":"32","author":"Wakefield RJ","year":"2005","journal-title":"J Rheumatol"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24646"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2014.05.025"},{"key":"e_1_2_9_21_1","first-page":"971","article-title":"Musculoskeletal injections: a review of the evidence","volume":"78","author":"Stephens MB","year":"2008","journal-title":"Am Fam Physician"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-05-284653"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-12-470898"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12267"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12539"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2010.1.191"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-014-2572-8"},{"key":"e_1_2_9_28_1","first-page":"1001","article-title":"Corticosteroid injection in rheumatoid arthritis does not increase rate of total joint arthroplasty","volume":"23","author":"Roberts WN","year":"1996","journal-title":"J Rheumatol"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1177\/2325967115581163"},{"key":"e_1_2_9_30_1","unstructured":"Neal RobertsW.Intraarticular and soft tissue injection:what agent(s) to inject and how frequently?UpToDate 2016; Accessed January 15 2016."},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20241"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH15-07-0525"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.12176"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0035-1564445"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2010.03962.x"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1053\/joca.2000.0398"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.11023"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780370316"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.21488"},{"key":"e_1_2_9_40_1","doi-asserted-by":"crossref","first-page":"499","DOI":"10.4049\/jimmunol.144.2.499","article-title":"IL\u20106 production by human articular chondrocytes. Modulation of its synthesis by cytokines, growth factors, and hormones in vitro","volume":"144","author":"Guerne PA","year":"1990","journal-title":"J Immunol"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-09-665091"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-03-635524"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2016.01.019"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms16010887"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1041550315"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(97)01464-7"},{"key":"e_1_2_9_47_1","first-page":"345","article-title":"Corticosteroids as antiangiogenic agents","volume":"19","author":"Oliver A","year":"2006","journal-title":"Ophthalmol Clin North Am"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.05-1651"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.1999.00608.x"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24133"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/micc.12273"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2012.09.001"},{"key":"e_1_2_9_53_1","first-page":"CD005328","article-title":"Intraarticular corticosteroid for treatment of osteoarthritis of the knee","author":"Bellamy N","year":"2006","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.12317"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2008.01679.x"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-01-195313"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1053\/berh.2001.0177"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-1241.2012.02963.x"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-014-0409-5"}],"container-title":["Haemophilia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhae.13057","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhae.13057","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hae.13057","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T13:40:19Z","timestamp":1695476419000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hae.13057"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,3]]},"references-count":58,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["10.1111\/hae.13057"],"URL":"https:\/\/doi.org\/10.1111\/hae.13057","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.735981149.793562043","asserted-by":"object"}]},"ISSN":["1351-8216","1365-2516"],"issn-type":[{"value":"1351-8216","type":"print"},{"value":"1365-2516","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,3]]}}}