{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T18:15:45Z","timestamp":1791656145921,"version":"4.3.4"},"reference-count":14,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,11,4]],"date-time":"2016-11-04T00:00:00Z","timestamp":1478217600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006400","name":"Alnylam Pharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006400","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009431","name":"Baxalta","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009431","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004702","name":"Baxter International","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004702","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004326","name":"Bayer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004326","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005614","name":"Biogen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005614","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008322","name":"CSL Behring","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004191","name":"Novo Nordisk","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004191","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000861","name":"Sparks","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000861","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Hepatitis C is the major cause of end\u2010stage liver disease and the major indication for orthotopic liver transplantation (<jats:styled-content style=\"fixed-case\">OLT<\/jats:styled-content>x) in individuals with haemophilia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To assess the epidemiology and outcomes of <jats:styled-content style=\"fixed-case\">OLT<\/jats:styled-content>x in U.S. haemophilia patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We investigated haemophilia liver transplant recipients between 1993 and 2012, using the Nationwide Inpatient Sample, identified by <jats:styled-content style=\"fixed-case\">ICD<\/jats:styled-content>9 code 50.59.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 11 267 (weighted <jats:italic>n<\/jats:italic> = 54 691) patients undergoing <jats:styled-content style=\"fixed-case\">OLT<\/jats:styled-content>x, 44 (0.4%; weighted <jats:italic>n<\/jats:italic> = 213) had haemophilia. Those with haemophilia were more likely than non\u2010haemophilic <jats:styled-content style=\"fixed-case\">OLT<\/jats:styled-content>x recipients to have bleeding complications (45.3% vs. 31.5%, <jats:italic>P<\/jats:italic> = 0.009) and hypovolemic shock (7.0% vs. 1.1%, <jats:italic>P<\/jats:italic> &lt; 0.0001). They also had a significantly higher incidence of <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> (24.8% vs. 0.5%, <jats:italic>P<\/jats:italic> &lt; 0.005), hepatitis B (16.2% vs. 7.9%, <jats:italic>P<\/jats:italic> = 0.04) and vitamin K deficiency (2.1% vs. 0.02%, <jats:italic>P<\/jats:italic> &lt; 0.001). In spite of these differences, there was no difference in in\u2010hospital mortality between haemophilic and non\u2010haemophilic recipients (6.8% vs. 6.2%, <jats:italic>P<\/jats:italic> = 0.9). In multivariate logistic regression, bleeding complications in haemophilia increased the risk of in\u2010hospital mortality by more than 3\u2010fold (<jats:italic>P<\/jats:italic> &lt; 0.0001), and disseminated intravascular coagulation increased the risk of bleeding complications in haemophilic recipients by over 10\u2010fold (<jats:italic>P<\/jats:italic> &lt; 0.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Bleeding complications are common in haemophilia <jats:styled-content style=\"fixed-case\">OLT<\/jats:styled-content>x recipients. Thus, aggressive correction of coagulation defects in this group may be a medically sound approach to reduce complications and mortality associated with <jats:styled-content style=\"fixed-case\">OLT<\/jats:styled-content>x.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hae.13104","type":"journal-article","created":{"date-parts":[[2016,11,4]],"date-time":"2016-11-04T07:29:37Z","timestamp":1478244577000},"page":"230-237","source":"Crossref","is-referenced-by-count":8,"title":["Bleeding and liver transplantation outcomes in haemophilia"],"prefix":"10.1111","volume":"23","author":[{"given":"K. D.","family":"Mehta","sequence":"first","affiliation":[{"name":"Department of Medicine University of Pittsburgh Medical Center Pittsburgh PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. V.","family":"Ragni","sequence":"additional","affiliation":[{"name":"Hemophilia Center of Western Pennsylvania Pittsburgh PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,11,4]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V76.1.254.254"},{"key":"e_1_2_8_3_1","first-page":"602","article-title":"Natural history of hepatitis C virus infection in multitransfused hemophiliacs: effect of coinfection with human immunodeficiency virus","volume":"6","author":"Eyster ME","year":"1993","journal-title":"J Acquir Immune Defic Syndr"},{"key":"e_1_2_8_4_1","first-page":"1584","article-title":"End\u2010stage liver disease in persons with hemophilia and transfusion\u2010associated infections","volume":"100","author":"Goedert JJ","year":"2002","journal-title":"Blood"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1994.tb08312.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1086\/319273"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V69.6.1721.1721"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.5482\/HAMO-14-07-0027"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2012.02905.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3182193cf3"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1477-2574.2010.00237.x"},{"key":"e_1_2_8_12_1","unstructured":"HCUP Nationwide Inpatient Sample (NIS). 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