{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T01:52:21Z","timestamp":1780105941428,"version":"3.54.0"},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,12,8]],"date-time":"2016-12-08T00:00:00Z","timestamp":1481155200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Several studies show the negative impact of haemophilia in health\u2010related quality of life (<jats:styled-content style=\"fixed-case\">HRQOL<\/jats:styled-content>). This issue is not well explored in developing countries.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This cross\u2010sectional study aimed to evaluate the <jats:styled-content style=\"fixed-case\">HRQOL<\/jats:styled-content> and its associated factors in patients with haemophilia A\/B in Brazil. Data were collected by questionnaire and in medical records, including a Portuguese version of Haem\u2010A\u2010Qol.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Brazilian patients were invited to the study and 175 participants (147 haemophilics A and 28 haemophilics B) were included. The total score of the Haem\u2010A\u2010QoL had a median of 36.96 (range of 0\u2013100), with worse performance in \u2018sport and leisure\u2019 and best on \u2018relationships\u2019 fields. <jats:styled-content style=\"fixed-case\">HRQOL<\/jats:styled-content> was worst among the older participants, the less educated, non\u2010white, non\u2010working, who were hospitalized in the last year, who did not have a single medical consultation and among those with the highest number of affected joints. Moreover, patients with hepatitis B had a significantly worse <jats:styled-content style=\"fixed-case\">HRQOL<\/jats:styled-content> in the domain \u2018sports and leisure\u2019, also observed in married patients. Otherwise, married individuals reported better <jats:styled-content style=\"fixed-case\">HRQOL<\/jats:styled-content> on \u2018dealing with the disease\u2019 domain. Patients with haemophilia B reported worse <jats:styled-content style=\"fixed-case\">HRQOL<\/jats:styled-content> in the domain \u2018self\u2010perception\u2019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The results obtained could be helpful in guidance of haemophilia treatment which is determinant to improve <jats:styled-content style=\"fixed-case\">HRQ<\/jats:styled-content>oL of the most vulnerable groups of patients. This work also reinforced the relevance of joint bleeds in all aspects of <jats:styled-content style=\"fixed-case\">HRQ<\/jats:styled-content>oL in haemophilic patients. The use of prophylactic factor concentrates and multidisciplinary treatments could contribute to improve the quality of life in haemophilia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hae.13130","type":"journal-article","created":{"date-parts":[[2016,12,8]],"date-time":"2016-12-08T06:11:11Z","timestamp":1481177471000},"page":"42-49","source":"Crossref","is-referenced-by-count":9,"title":["Determining the health\u2010related quality of life in individuals with haemophilia in developing economies: results from the Brazilian population"],"prefix":"10.1111","volume":"23","author":[{"given":"T.","family":"Salomon","sequence":"first","affiliation":[{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Sa\u00fade Coletiva \u2013 Fiocruz Minas Belo Horizonte Minas Gerais Brazil"},{"name":"Grupo de Qualidade de Vida em Hematologia e Hemoterapia Belo Horizonte Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. 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