{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T12:07:51Z","timestamp":1784030871601,"version":"3.55.0"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,2,15]],"date-time":"2017-02-15T00:00:00Z","timestamp":1487116800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31271161"],"award-info":[{"award-number":["31271161"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Using diffusional kurtosis imaging (<jats:styled-content style=\"fixed-case\">DKI<\/jats:styled-content>) to assess the impact of emotional disorders on microstructural changes of the brain in children with haemophilia A.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Diffusional kurtosis imaging was acquired from haemophilia A (<jats:italic>n<\/jats:italic>\u00a0=\u00a022) and controls (<jats:italic>n<\/jats:italic>\u00a0=\u00a022) using a 3T scanner. A regression analysis of frontal, cingulate, hippocampus, insula and amygdala regions of interest (<jats:styled-content style=\"fixed-case\">ROI<\/jats:styled-content>s) was conducted. Clinical data and results of psychological tests were collected. A paired <jats:italic>t<\/jats:italic>\u2010test was used to analyse the differences between the two groups\u2019 <jats:styled-content style=\"fixed-case\">ROI<\/jats:styled-content>s, and the Spearman test was used to analyse the correlation between <jats:styled-content style=\"fixed-case\">ROI<\/jats:styled-content>s and psychological tests or clinical data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fractional anisotropy (<jats:styled-content style=\"fixed-case\">FA<\/jats:styled-content>) in the left middle cingulate and right hippocampus; mean diffusion (<jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content>) in the frontal lobe, right anterior cingulate and right middle cingulate showed varying degrees of increase in the <jats:styled-content style=\"fixed-case\">ROI<\/jats:styled-content> compared to controls (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.003). <jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content> in the frontal lobe and the course of disease (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05), <jats:styled-content style=\"fixed-case\">FA<\/jats:styled-content> in the right hippocampus and the social score of the self\u2010consciousness scale (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01) had a positive correlation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study is the first to evaluate the relationship between emotion disorders and cognitive changes in the microstructure of the brain in children with haemophilia A, suggesting that <jats:styled-content style=\"fixed-case\">DKI<\/jats:styled-content> provides more information about tissue microstructural changes than do the conventional image method and traditional psychological tests.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hae.13159","type":"journal-article","created":{"date-parts":[[2017,2,16]],"date-time":"2017-02-16T04:32:47Z","timestamp":1487219567000},"source":"Crossref","is-referenced-by-count":5,"title":["Preliminary evaluation of altered brain microstructure in the emotion\u2013cognition region in children with haemophilia A: a diffusional kurtosis imaging study"],"prefix":"10.1111","volume":"23","author":[{"given":"D.","family":"Hu","sequence":"first","affiliation":[{"name":"Imaging Center Beijing Children's Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Kang","sequence":"additional","affiliation":[{"name":"Imaging Center Beijing Children's Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Lv","sequence":"additional","affiliation":[{"name":"Imaging Center Beijing Children's Hospital Capital 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