{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T05:02:18Z","timestamp":1761541338908},"reference-count":44,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,1,22]],"date-time":"2017-01-22T00:00:00Z","timestamp":1485043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:p>Von Willebrand disease (<jats:styled-content style=\"fixed-case\">VWD<\/jats:styled-content>) is an inherited haemorrhagic disorder caused by a quantitative or qualitative defect of von Willebrand factor (<jats:styled-content style=\"fixed-case\">VWF<\/jats:styled-content>), a multimeric plasma glycoprotein that plays a key role in platelet adhesion to the subendothelium and acts as a carrier of factor <jats:styled-content style=\"fixed-case\">VIII<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">FVIII<\/jats:styled-content>) in blood. Patients with <jats:styled-content style=\"fixed-case\">VWD<\/jats:styled-content> experience bleeding symptoms that are mainly localized in mucous membranes and soft tissues, and their severity depends on the degree of the primary reduction in <jats:styled-content style=\"fixed-case\">VWF<\/jats:styled-content> and the secondary deficiency of <jats:styled-content style=\"fixed-case\">FVIII<\/jats:styled-content> in plasma. Because <jats:styled-content style=\"fixed-case\">VWD<\/jats:styled-content> patients are also at increased risk of perioperative bleeding, a prophylactic treatment aimed to correct the dual haemostatic defect (i.e. <jats:styled-content style=\"fixed-case\">VWF<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">FVIII<\/jats:styled-content>) is warranted. This review summarizes knowledge on the current management of patients undergoing major surgery, focusing on the peri\u2010surgical laboratory monitoring of replacement therapy with <jats:styled-content style=\"fixed-case\">VWF<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">FVIII<\/jats:styled-content> concentrates. We suggest to monitor plasma levels of <jats:styled-content style=\"fixed-case\">FVIII<\/jats:styled-content> coagulant activity in the postoperative period rather than a surrogate maker of platelet\u2010binding <jats:styled-content style=\"fixed-case\">VWF<\/jats:styled-content> activity as the ristocetin cofactor assay and its recent modifications.<\/jats:p>","DOI":"10.1111\/hae.13165","type":"journal-article","created":{"date-parts":[[2017,1,23]],"date-time":"2017-01-23T01:32:46Z","timestamp":1485135166000},"page":"182-187","source":"Crossref","is-referenced-by-count":19,"title":["Laboratory monitoring of replacement therapy for major surgery in von Willebrand disease"],"prefix":"10.1111","volume":"23","author":[{"given":"P. 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