{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T11:19:16Z","timestamp":1793272756463,"version":"4.5.0"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,5,4]],"date-time":"2017-05-04T00:00:00Z","timestamp":1493856000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Haemophilic synovitis is caused by chronic accumulation of blood in the joint. Conservative treatment is insufficient to solve this pathology. Platelet\u2010rich plasma (<jats:styled-content style=\"fixed-case\">PRP<\/jats:styled-content>) has a high concentration of growth factors (<jats:styled-content style=\"fixed-case\">GF<\/jats:styled-content>s) that play a key role in regulation and stimulation of healing processes. The aim of this study was to describe the effect of <jats:styled-content style=\"fixed-case\">PRP<\/jats:styled-content> injection in chronic synovitis of the joints in patients with haemophilia (<jats:styled-content style=\"fixed-case\">PWH<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p>Nineteen patients with 28 joints were treated at our centre in Buenos Aires, Argentina between December 2014 and December 2015. Eighteen were Haemophilia type A (17 severe, one mild) and one was type B severe. Mean age was 26 years old. Chronic synovitis was present in two ankles, seven elbows and 19 knee joints. All affected joints were evaluated for range of motion (<jats:styled-content style=\"fixed-case\">ROM<\/jats:styled-content>), perimeter, Haemophilia Joint Health Score (<jats:styled-content style=\"fixed-case\">HJHS<\/jats:styled-content>), number of bleedings episodes and Visual Analogue Scale (<jats:styled-content style=\"fixed-case\">VAS<\/jats:styled-content>). Evaluations were before treatment and 3 and 6 months after treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A mean volume of 4 mL of <jats:styled-content style=\"fixed-case\">PRP<\/jats:styled-content> was injected into the joint cavity. The statistical analysis before and after treatments revealed a statistically significant (<jats:italic>P<\/jats:italic> &lt; 0.001) decrease in the <jats:styled-content style=\"fixed-case\">HJHS<\/jats:styled-content> score. Decrease in joint bleeding episodes was also statistically significant (<jats:italic>P<\/jats:italic> &lt; 0.001). All patients reported pain relief and <jats:styled-content style=\"fixed-case\">VAS<\/jats:styled-content> scores were statistically significant (<jats:italic>P<\/jats:italic> &lt; 0.001). Joint perimeter also showed a statistically significant difference (<jats:italic>P<\/jats:italic> &lt; 0.001). No complications were observed in any of the patients, either during blood collection or during <jats:styled-content style=\"fixed-case\">PRP<\/jats:styled-content> injection, even for inhibitor patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Platelet\u2010rich plasma is a useful, safe, and inexpensive treatment for chronic haemophilic synovitis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hae.13212","type":"journal-article","created":{"date-parts":[[2017,5,4]],"date-time":"2017-05-04T07:46:38Z","timestamp":1493883998000},"page":"613-619","source":"Crossref","is-referenced-by-count":21,"title":["Platelet Rich Plasma for Chronic Synovitis Treatment in Patients with Haemophilia"],"prefix":"10.1111","volume":"23","author":[{"given":"H.","family":"Caviglia","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery and Traumatology Dr. Juan A. Fern\u00e1ndez General Hospital Buenos Aires Argentina"},{"name":"Haemophilia Foundation Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9185-2430","authenticated-orcid":false,"given":"M. E.","family":"Landro","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery and Traumatology Dr. Juan A. Fern\u00e1ndez General Hospital Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Daffunchio","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery and Traumatology Dr. Juan A. Fern\u00e1ndez General Hospital Buenos Aires Argentina"},{"name":"Haemophilia Foundation Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Galatro","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery and Traumatology Dr. Juan A. Fern\u00e1ndez General Hospital Buenos Aires Argentina"},{"name":"Haemophilia Foundation Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. L.","family":"Douglas Price","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery and Traumatology Dr. Juan A. Fern\u00e1ndez General Hospital Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Salgado","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery and Traumatology Dr. Juan A. Fern\u00e1ndez General Hospital Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Neme","sequence":"additional","affiliation":[{"name":"Haemophilia Foundation Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,5,4]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"326","article-title":"Integrative approach in haemophillic arthropathy of the knee","volume":"4","author":"Maruli A","year":"2015","journal-title":"Acta Med Indones"},{"key":"e_1_2_7_3_1","first-page":"1","article-title":"Chronic hemophilic synovitis: the role of radiosynovectomy","volume":"33","author":"Silva M","year":"2004","journal-title":"Treat Haemophilia"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.2002.00585.x"},{"issue":"2","key":"e_1_2_7_5_1","first-page":"3","article-title":"Prophylaxis: musculoskeletal evaluations","volume":"30","author":"Gilbert SM","year":"1993","journal-title":"Semin Hematol"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-198006000-00018"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2002-20596"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.3109\/rhe1.1969.15.issue-1-4.14"},{"key":"e_1_2_7_9_1","unstructured":"Tezanos PintoM P\u00e9rez\u2010BiancoR BengoRM.La artropat\u00eda hemof\u00edlica. 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