{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T18:08:11Z","timestamp":1789495691686,"version":"build-2803163510"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,4,16]],"date-time":"2017-04-16T00:00:00Z","timestamp":1492300800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004191","name":"Novo Nordisk","doi-asserted-by":"publisher","award":["NCT01988532"],"award-info":[{"award-number":["NCT01988532"]}],"id":[{"id":"10.13039\/501100004191","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Haemophilia is characterized by frequent haemarthrosis, leading to acute\/chronic joint pain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To assess self\u2010reported prevalence, description and management of pain in adult males with mild\u2010to\u2010severe haemophilia and history of joint pain\/bleeding.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Participants completed a pain survey and five patient\u2010reported outcome instruments assessing pain, functional impairment and health\u2010related quality of life (HRQoL).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 381 participants enrolled, median age was 34 years; 77% had haemophilia A, 71% had severe disease and 65% were overweight\/obese. Many (56%) were not receiving routine infusions; 30% never received routine infusions. During the prior 6 months, 20% experienced acute pain, 34% chronic pain and 32% both acute\/chronic pain. Subjects with both acute\/chronic pain (vs. none, acute or chronic) were more likely to be depressed (30% vs. 0\u201315%), obese (35% vs. 20\u201329%) and have lower <jats:styled-content style=\"fixed-case\">HRQ<\/jats:styled-content>oL (mean <jats:styled-content style=\"fixed-case\">EQ<\/jats:styled-content>\u20105D visual analog scale, 69 vs. 83\u201386) and function (median overall Hemophilia Activities List, 60 vs. 88\u201399). Most common analgesics used for acute\/chronic pain during the prior 6 months were acetaminophen (62%\/55%) and non\u2010steroidal anti\u2010inflammatory drugs (34%\/49%); most common non\u2010pharmacologic strategies were ice (65%\/33%) and rest (51%\/33%). Hydrocodone\u2010acetaminophen was the most common opioid for both acute\/chronic pain (30%); other long\u2010acting opioids were infrequently used specifically for chronic but not acute pain (morphine, 7%; methadone, 6%; fentanyl patch, 2%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients with chronic pain, particularly those with both acute\/chronic pain, frequently experience psychological issues, functional disability and reduced <jats:styled-content style=\"fixed-case\">HRQ<\/jats:styled-content>oL. Treatment strategies for acute pain (e.g. routine infusions to prevent bleeding) and for chronic pain (e.g. long\u2010acting opioids) may be underused.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hae.13214","type":"journal-article","created":{"date-parts":[[2017,4,17]],"date-time":"2017-04-17T02:36:40Z","timestamp":1492396600000},"page":"556-565","source":"Crossref","is-referenced-by-count":108,"title":["Self\u2010reported prevalence, description and management of pain in adults with haemophilia: methods, demographics and results from the Pain, Functional Impairment, and Quality of life (P\u2010FiQ) study"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0758-286X","authenticated-orcid":false,"given":"M.","family":"Witkop","sequence":"first","affiliation":[{"name":"Munson Medical Center Traverse City MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Neff","sequence":"additional","affiliation":[{"name":"Cleveland Clinic Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. W.","family":"Buckner","sequence":"additional","affiliation":[{"name":"University of Colorado School of Medicine Aurora CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9289-4862","authenticated-orcid":false,"given":"M.","family":"Wang","sequence":"additional","affiliation":[{"name":"University of Colorado School of Medicine Aurora CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Batt","sequence":"additional","affiliation":[{"name":"Wake Forest School of Medicine Winston\u2010Salem NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. M.","family":"Kessler","sequence":"additional","affiliation":[{"name":"Georgetown University Hospital Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Quon","sequence":"additional","affiliation":[{"name":"Orthopaedic Hemophilia Treatment Center Orthopaedic Institute for Children Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Boggio","sequence":"additional","affiliation":[{"name":"Rush University Medical Center Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Recht","sequence":"additional","affiliation":[{"name":"Oregon Health &amp; Science University Portland OR USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Baumann","sequence":"additional","affiliation":[{"name":"University of Minnesota Health Center for Bleeding and Clotting Disorders Minneapolis MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Z.","family":"Gut","sequence":"additional","affiliation":[{"name":"Clinical, Medical and Regulatory Affairs Novo Nordisk Inc. Plainsboro NJ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4499-1526","authenticated-orcid":false,"given":"D. L.","family":"Cooper","sequence":"additional","affiliation":[{"name":"Clinical, Medical and Regulatory Affairs Novo Nordisk Inc. Plainsboro NJ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. 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