{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:16:02Z","timestamp":1740125762378,"version":"3.37.3"},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,7,9]],"date-time":"2017-07-09T00:00:00Z","timestamp":1499558400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Pfizer NV","award":["WI181623 - 2013 ASPIRE EU Haemo - Quantification of foot biomechanics in haemophilic children with ankle arthropathy through a state-of the start integrated approach"],"award-info":[{"award-number":["WI181623 - 2013 ASPIRE EU Haemo - Quantification of foot biomechanics in haemophilic children with ankle arthropathy through a state-of the start integrated approach"]}]},{"name":"World Federation of Hemophilia Canada 2014 Recipient"},{"name":"Bayer Hemophilia Awards"},{"name":"Early Career Investigator Award 2012 for S\u00e9bastien Lobet"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Adequate management of haemophilia patients requires early detection of joint impairment in relatively asymptomatic patients. This study sought to quantify the impact of the ankle's structural impairment on muscle strength in children, adolescent and young adults with haemophilia (CAAwH).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010three <jats:styled-content style=\"fixed-case\">CAA<\/jats:styled-content>wH underwent bilateral magnetic resonance imaging (<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>) assessing the anatomical status of tibiotalar joint (<jats:styled-content style=\"fixed-case\">TTJ<\/jats:styled-content>) and subtalar joint (<jats:styled-content style=\"fixed-case\">STJ<\/jats:styled-content>) using the International Prophylaxis Study Group <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> scale. An isokinetic dynamometer enabled a detailed evaluation of muscle strength at slow and fast speed. In parallel, 10 typically developing healthy boys (<jats:styled-content style=\"fixed-case\">TDB<\/jats:styled-content>) participated in a 1\u2010week interval test\u2010retest assessment to assess the test's reliability.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010six <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> ankle scores were obtained, with 11 patients unilaterally affected and one bilaterally. Of the 13 affected feet, nine showed abnormalities at <jats:styled-content style=\"fixed-case\">TTJ<\/jats:styled-content>, three at the posterior <jats:styled-content style=\"fixed-case\">STJ<\/jats:styled-content> and the remaining one at both joints. Muscle strength was not reduced in <jats:styled-content style=\"fixed-case\">CAA<\/jats:styled-content>wH exhibiting <jats:styled-content style=\"fixed-case\">TTJ<\/jats:styled-content> and\/or <jats:styled-content style=\"fixed-case\">STJ<\/jats:styled-content> arthropathy, as compared to healthy <jats:styled-content style=\"fixed-case\">TDB<\/jats:styled-content>, nor was there any difference between the <jats:styled-content style=\"fixed-case\">CAA<\/jats:styled-content>wH's affected or unaffected sides.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Contrarily to adult patients, <jats:styled-content style=\"fixed-case\">CAA<\/jats:styled-content>wH with repeated ankle bleeding may be less impaired than current structural evaluations imply, with possibly a latency between the occurrence of structural and functional damage.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hae.13274","type":"journal-article","created":{"date-parts":[[2017,7,9]],"date-time":"2017-07-09T23:06:38Z","timestamp":1499641598000},"source":"Crossref","is-referenced-by-count":6,"title":["Deficits of ankle muscle strength not found in children, adolescents and young adults with haemophilic ankle arthropathy"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3829-6850","authenticated-orcid":false,"given":"S.","family":"Lobet","sequence":"first","affiliation":[{"name":"Secteur des Sciences de la Sant\u00e9 Institut de Recherche Exp\u00e9rimentale et Clinique Neuromusculoskeletal Lab (NMSK) Universit\u00e9 catholique de Louvain  Brussels Belgium"},{"name":"Service d'h\u00e9matologie Cliniques universitaires Saint\u2010Luc  Brussels Belgium"},{"name":"Service de m\u00e9decine physique et r\u00e9adaptation Cliniques universitaires Saint\u2010Luc  Brussels 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