{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T23:05:57Z","timestamp":1778540757745,"version":"3.51.4"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,9,11]],"date-time":"2017-09-11T00:00:00Z","timestamp":1505088000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Repeated haemarthrosis is widely accepted as the triggering cause of synovitis and haemophilic arthropathy. A first\u2010line treatment of chronic synovitis is radiosynoviorthesis (<jats:styled-content style=\"fixed-case\">RS<\/jats:styled-content>). The aim of this study was to evaluate the <jats:styled-content style=\"fixed-case\">RS<\/jats:styled-content> effects on the progression of arthropathy and on a reduction in bleeding in patients with haemophilia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>An observational\u2010retrospective study was performed. Bleeding episodes in the 12\u00a0months following and in the 12\u00a0months preceding <jats:styled-content style=\"fixed-case\">RS<\/jats:styled-content> was compared. The arthropathy was clinically and radiologically analysed by age range, joint and subject, comparing those undergoing <jats:styled-content style=\"fixed-case\">RS<\/jats:styled-content> (Radiosynoviorthesis Group, <jats:styled-content style=\"fixed-case\">RSG<\/jats:styled-content>) against those not undergoing this treatment (Non\u2010Radiosynoviorthesis Group, Non\u2010<jats:styled-content style=\"fixed-case\">RSG<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred and seventy\u2010four <jats:styled-content style=\"fixed-case\">RS<\/jats:styled-content> were performed in 71 patients (<jats:sup>90<\/jats:sup>Y in Knees and <jats:sup>186<\/jats:sup>Re in elbows\/ankles\/shoulder). <jats:styled-content style=\"fixed-case\">RS<\/jats:styled-content> resulted in significant reduction in bleeding (582 preintervention and 168 postintervention, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). In general, the level of arthropathy measured clinically and radiologically was greater with age increase in both groups (<jats:styled-content style=\"fixed-case\">RSG<\/jats:styled-content> and Non\u2010<jats:styled-content style=\"fixed-case\">RSG<\/jats:styled-content>), especially in the 25\u201040 age range. A significant increase (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05) in the progression of arthropathy was also observed, both globally by patient and specifically for each joint, in non\u2010<jats:styled-content style=\"fixed-case\">RSG<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">RSG<\/jats:styled-content> group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">RS<\/jats:styled-content> is an effective method to reduce the number of haemarthrosis episodes in chronic synovitis. Moreover, <jats:styled-content style=\"fixed-case\">RS<\/jats:styled-content> can positively affect arthropathy by slowing down its progression. However, the results obtained suggest that arthropathy may be conditioned by the subject's age, regardless of whether or not the joint has undergone <jats:styled-content style=\"fixed-case\">RS<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hae.13326","type":"journal-article","created":{"date-parts":[[2017,9,11]],"date-time":"2017-09-11T09:22:38Z","timestamp":1505121758000},"source":"Crossref","is-referenced-by-count":14,"title":["Effect of radiosynoviorthesis on the progression of arthropathy and haemarthrosis reduction in haemophilic patients"],"prefix":"10.1111","volume":"23","author":[{"given":"M.","family":"Querol\u2010Giner","sequence":"first","affiliation":[{"name":"Servicio de Rehabilitaci\u00f3n, Hospital de Sagunto  Valencia Spain"},{"name":"Department of Physiotherapy University of Valencia  Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0841-5767","authenticated-orcid":false,"given":"S.","family":"P\u00e9rez\u2010Alenda","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy University of Valencia  Valencia Spain"},{"name":"Haemostasis and Thrombosis Unit University and Polytechnic Hospital La Fe  Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Aguilar\u2010Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy University of Valencia  Valencia Spain"},{"name":"Rehabilitation Service University and Polytechnic Hospital La Fe  Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. J.","family":"Carrasco","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy University of Valencia  Valencia Spain"},{"name":"Intelligent Data Analysis Laboratory University of Valencia  Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Bonanad","sequence":"additional","affiliation":[{"name":"Haemostasis and Thrombosis Unit University and Polytechnic Hospital La Fe  Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Querol","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy University of Valencia  Valencia Spain"},{"name":"Haemostasis and Thrombosis Unit University and Polytechnic Hospital La Fe  Valencia 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