{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T11:25:55Z","timestamp":1785410755418,"version":"3.56.0"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,9,5]],"date-time":"2017-09-05T00:00:00Z","timestamp":1504569600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Joint bleeds in patients with haemophilia may result in haemophilic arthropathy. Monitoring joint health is essential for identifying early signs of deterioration and allows timely adjustment of treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim was to describe changes in joint health over 5\u201010\u00a0years follow\u2010up and identify factors associated with joint health deterioration in patients with haemophilia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A post hoc analysis was performed from previous cohort studies in patients with moderate\/severe haemophilia, \u226516\u00a0years. Joint health of ankles, knees and elbows was measured with the Haemophilia Joint Health Score (<jats:styled-content style=\"fixed-case\">HJHS<\/jats:styled-content>) from 2006\u20102008 (T0) to 2011\u20102016 (T1). Analyses were performed on patient level (\u0394<jats:styled-content style=\"fixed-case\">HJHS<\/jats:styled-content>\u2010total) and joint level (\u0394<jats:styled-content style=\"fixed-case\">HJHS<\/jats:styled-content>\u2010joint). Deterioration was defined as \u0394<jats:styled-content style=\"fixed-case\">HJHS<\/jats:styled-content>\u2010total \u22654 and \u0394<jats:styled-content style=\"fixed-case\">HJHS<\/jats:styled-content>\u2010joint \u22652.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty\u2010two patients (median age 25, 73% severe haemophilia, median [interquartile range] 0.0 [0.0;2.0] joint bleeds between T0 to T1) were included. After median 8\u00a0years, <jats:styled-content style=\"fixed-case\">HJHS<\/jats:styled-content>\u2010total deteriorated in 37% and <jats:styled-content style=\"fixed-case\">HJHS<\/jats:styled-content>\u2010joint in 17%. Ankle joints (31%) showed deterioration more often than elbows (19%) and knees (3%). Deterioration of <jats:styled-content style=\"fixed-case\">HJHS<\/jats:styled-content>\u2010total was only associated with severe haemophilia. Deterioration of <jats:styled-content style=\"fixed-case\">HJHS<\/jats:styled-content>\u2010joint was weakly associated with a lower <jats:styled-content style=\"fixed-case\">HJHS<\/jats:styled-content> at baseline and more self\u2010reported limitations in activities, and strongly with more joint bleeds between T0 and T1 and presence of synovitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In 37% of patients with moderate\/severe haemophilia and low joint bleeding rates, joint health deteriorated over 5\u201010\u00a0years. Ankle and elbow joints showed deterioration most frequently. Factors found in this study help to identify which joints need frequent monitoring in patients with haemophilia with access to early prophylaxis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hae.13327","type":"journal-article","created":{"date-parts":[[2017,9,5]],"date-time":"2017-09-05T12:37:01Z","timestamp":1504615021000},"page":"934-940","source":"Crossref","is-referenced-by-count":61,"title":["Monitoring joint health in haemophilia: Factors associated with deterioration"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2920-2258","authenticated-orcid":false,"given":"I. A. R.","family":"Kuijlaars","sequence":"first","affiliation":[{"name":"Van Creveldkliniek University Medical Center Utrecht  Utrecht The Netherlands"},{"name":"Physical Therapy Sciences Program in Clinical Health Sciences University Medical Center Utrecht  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1910-999X","authenticated-orcid":false,"given":"M. A.","family":"Timmer","sequence":"additional","affiliation":[{"name":"Van Creveldkliniek University Medical Center Utrecht  Utrecht The Netherlands"},{"name":"Physical Therapy Sciences Program in Clinical Health Sciences University Medical Center Utrecht  Utrecht The Netherlands"},{"name":"Physical Therapy Research Department of Rehabilitation, Physiotherapy Science &amp; Sport Brain Center Rudolf Magnus University Medical Center Utrecht  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"de Kleijn","sequence":"additional","affiliation":[{"name":"Van Creveldkliniek University Medical Center Utrecht  Utrecht The Netherlands"},{"name":"Physical Therapy Research Department of Rehabilitation, Physiotherapy Science &amp; Sport Brain Center Rudolf Magnus University Medical Center Utrecht  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. F.","family":"Pisters","sequence":"additional","affiliation":[{"name":"Physical Therapy Sciences Program in Clinical Health Sciences University Medical Center Utrecht  Utrecht The Netherlands"},{"name":"Physical Therapy Research Department of Rehabilitation, Physiotherapy Science &amp; Sport Brain Center Rudolf Magnus University Medical Center Utrecht  Utrecht The Netherlands"},{"name":"Center for Physical Therapy Research and Innovation in Primary Care Leidsche Rijn Julius Health Care Centers  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7126-6613","authenticated-orcid":false,"given":"K.","family":"Fischer","sequence":"additional","affiliation":[{"name":"Van Creveldkliniek University Medical Center Utrecht  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,9,5]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2012.02909.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2008.07386.x"},{"key":"e_1_2_8_4_1","first-page":"91","volume-title":"Nederlandse Vereniging van Hemofiliebehandelaars (NVHB). 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