{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T06:48:25Z","timestamp":1773298105960,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,9,5]],"date-time":"2017-09-05T00:00:00Z","timestamp":1504569600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Due to lack of patient\/health care provider awareness causing delayed diagnosis, the bleeding phenotype and provider interventions in adolescents with heavy menstrual bleeding (<jats:styled-content style=\"fixed-case\">HMB<\/jats:styled-content>) and bleeding disorders (<jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content>) may be different when compared to adults.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of this study was to compare\/characterize bleeding phenotype and provider interventions in postmenarchal adolescents\u00a0&lt;\u00a018\u00a0years and premenopausal adults\u00a0<jats:styled-content>\u2265\u00a0<\/jats:styled-content>18\u00a0years with <jats:styled-content style=\"fixed-case\">HMB<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patient demographics, <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content>, and provider interventions\/therapy details for <jats:styled-content style=\"fixed-case\">HMB<\/jats:styled-content> were compared between both age groups enrolled in the Centers for Disease Control and Prevention (<jats:styled-content style=\"fixed-case\">CDC<\/jats:styled-content>) Female Universal Data Collection (<jats:styled-content style=\"fixed-case\">UDC<\/jats:styled-content>) surveillance project in United States hemophilia treatment centres. Cross\u2010sectional descriptive analyses including frequency distributions, summary statistics, bivariate and logistic regression analyses were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 269 females (79 adolescents; median age 16\u00a0years, interquartile range (<jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content>)\u00a0=\u00a02; 190 adults; median age 27\u00a0years, <jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content>\u00a0=\u00a013) evaluated, <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content> distribution was similar in both groups. Compared to adolescents, adults more often had family history of bleeding (Adjusted odds ratios [<jats:styled-content style=\"fixed-case\">AOR<\/jats:styled-content>]\u00a0=\u00a02.6, 1.3\u20105.6), delay in diagnosis (<jats:styled-content style=\"fixed-case\">AOR<\/jats:styled-content>\u00a0=\u00a02.5, 1.2\u20104.9), bleeding with dental procedures (<jats:styled-content style=\"fixed-case\">AOR<\/jats:styled-content>\u00a0=\u00a02.0, 1.0\u20104.0), gastrointestinal bleeding (<jats:styled-content style=\"fixed-case\">AOR<\/jats:styled-content>\u00a0=\u00a04.6, 1.0\u201021.9), anaemia (<jats:styled-content style=\"fixed-case\">AOR<\/jats:styled-content>\u00a0=\u00a02.7, 1.4\u20105.2), utilized desmopressin less often (<jats:styled-content style=\"fixed-case\">AOR<\/jats:styled-content>\u00a0=\u00a00.4, 0.2\u20100.8) and underwent gynaecologic procedure\/surgery more frequently (<jats:styled-content style=\"fixed-case\">AOR<\/jats:styled-content>\u00a0=\u00a05.9, 1.3\u201027.3).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Bleeding phenotypes of adolescents and adults with <jats:styled-content style=\"fixed-case\">HMB<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content> were different with more frequent bleeding complications, anaemia, gynaecologic procedures\/surgeries, less desmopressin use and more delay in diagnosing <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content> in adults. Longitudinal studies are needed to determine whether improved patient\/provider awareness and education will translate to early diagnosis and timely management of <jats:styled-content style=\"fixed-case\">BD<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">HMB<\/jats:styled-content> in adolescents that may prevent\/reduce future haematologic\/gynaecologic complications.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hae.13330","type":"journal-article","created":{"date-parts":[[2017,9,5]],"date-time":"2017-09-05T12:32:54Z","timestamp":1504614774000},"page":"63-69","source":"Crossref","is-referenced-by-count":21,"title":["Differences in bleeding phenotype and provider interventions in postmenarchal adolescents when compared to adult women with bleeding disorders and heavy menstrual bleeding"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5324-7053","authenticated-orcid":false,"given":"L. V.","family":"Srivaths","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Section of Hematology\/Oncology Baylor College of Medicine  Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Q. C.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Division of Blood Disorders  National Center on Birth Defects and Developmental Disabilities Centers for Disease Control and Prevention  Atlanta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V. R.","family":"Byams","sequence":"additional","affiliation":[{"name":"Division of Blood Disorders  National Center on Birth Defects and Developmental Disabilities Centers for Disease Control and Prevention  Atlanta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. E.","family":"Dietrich","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Baylor College of Medicine  Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. H.","family":"James","sequence":"additional","affiliation":[{"name":"Division of Maternal\u2010Fetal Medicine Duke University  Durham NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. A.","family":"Kouides","sequence":"additional","affiliation":[{"name":"Mary M. Gooley Hemophilia Treatment Center  Rochester NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Kulkarni","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Human Development Michigan State University  East Lansing MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the Hemophilia Treatment Centers Network Investigators","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,9,5]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ogc.2008.12.002"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpag.2012.07.001"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2010.02315.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1351-8216.2003.00832.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2011.02558.x"},{"key":"e_1_2_8_7_1","volume-title":"The Nation's Latino Population Is Defined by Its Youth","author":"Patten E","year":"2016"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2011.09.017"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-10-675140"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1538-7836.2003.00061.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12293"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2012.07.010"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/GCO.0b013e3283562bcb"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpag.2010.08.007"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12254"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2009.07610.x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.2217\/WHE.11.9"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181f20177"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpag.2014.12.012"}],"container-title":["Haemophilia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhae.13330","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hae.13330","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T17:17:13Z","timestamp":1695489433000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hae.13330"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,5]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["10.1111\/hae.13330"],"URL":"https:\/\/doi.org\/10.1111\/hae.13330","archive":["Portico"],"relation":{},"ISSN":["1351-8216","1365-2516"],"issn-type":[{"value":"1351-8216","type":"print"},{"value":"1365-2516","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,5]]}}}