{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T16:38:06Z","timestamp":1778776686136,"version":"3.51.4"},"reference-count":44,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T00:00:00Z","timestamp":1513900800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Haemophilic ankle arthropathy is caused by recurrent spontaneous joint haemorrhaging and leads to pain, deformity and loss of function. In the presence of advanced articular deterioration, therapeutic options are confined to either arthroplasty or arthrodesis, the latter still being referred to as the procedure of choice. However, total ankle replacement (<jats:styled-content style=\"fixed-case\">TAR<\/jats:styled-content>) has recently gained acceptance as an alternative.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate the mid\u2010 to long\u2010term results of <jats:styled-content style=\"fixed-case\">TAR<\/jats:styled-content> in haemophilic ankle arthropathy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Seventeen <jats:styled-content style=\"fixed-case\">TAR<\/jats:styled-content>s in 14 male patients (mean age: 43\u00a0years [range, 27.4\u201057.6]), implanted between 1998 and 2012, were retrospectively analysed. Implant survival was estimated using Kaplan\u2010Meier analysis. Haemophilic\/viral status, complications and revision surgeries were recorded. Follow\u2010up assessment of 12 <jats:styled-content style=\"fixed-case\">TAR<\/jats:styled-content>s was performed 9.6\u00a0years (range, 3.3\u201017.8) postoperatively, including clinical examination, pain and satisfaction scales, the American Orthopaedic Foot and Ankle Society (<jats:styled-content style=\"fixed-case\">AOFAS<\/jats:styled-content>) hindfoot score, and the <jats:styled-content style=\"fixed-case\">SF<\/jats:styled-content>\u201036. Radiographic evaluation of pre\u2010 and follow\u2010up radiographs was conducted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Estimated implant survival was 94% at 5, 85% at 10 and 70% at 15\u00a0years, respectively. Three cases required revision surgery. At follow\u2010up, 9.6\u00a0years (range, 3.3\u201017.8) postoperatively, the level of satisfaction was 76% (range, 50\u2010100) and of pain 2\/10 (range, 0\u20106) on the <jats:styled-content style=\"fixed-case\">VAS<\/jats:styled-content>. Range of motion had increased significantly (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.037). The <jats:styled-content style=\"fixed-case\">SF<\/jats:styled-content>\u201036 summary scores were comparable to those of a matched standard population. The <jats:styled-content style=\"fixed-case\">AOFAS<\/jats:styled-content> hindfoot score averaged 81 points (range, 73\u201090). All radiographs revealed component loosening or periprosthetic radiolucency.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Total ankle replacement in the presence of advanced haemophilic arthropathy is a viable treatment option with favourable mid\u2010\/long\u2010term results, maintaining mobility of the ankle joint.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hae.13386","type":"journal-article","created":{"date-parts":[[2017,12,24]],"date-time":"2017-12-24T08:27:32Z","timestamp":1514104052000},"page":"307-315","source":"Crossref","is-referenced-by-count":19,"title":["Mid\u2010 to long\u2010term results of total ankle replacement in patients with haemophilic arthropathy: A 10\u2010year follow\u2010up"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7670-4229","authenticated-orcid":false,"given":"F.","family":"Eckers","sequence":"first","affiliation":[{"name":"Orthopaedics Balgrist University Hospital University of Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. 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