{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T04:48:08Z","timestamp":1780721288973,"version":"3.54.1"},"reference-count":85,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T00:00:00Z","timestamp":1513900800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:p>von Willebrand disease (<jats:styled-content style=\"fixed-case\">VWD<\/jats:styled-content>) and haemophilia represent common inherited or acquired bleeding disorders, but many laboratories and clinicians continue to struggle with their diagnosis or exclusion. Difficulties in achieving a correct diagnosis or exclusion of <jats:styled-content style=\"fixed-case\">VWD<\/jats:styled-content> or haemophilia might be due to analytical issues. Sometimes assays may generate a wrong result (ie an analytical error) or may have limitations in their dynamic range of measurement and\/or their level of low analytical sensitivity. Less well recognized is the influence of preanalytical issues on the diagnosis of <jats:styled-content style=\"fixed-case\">VWD<\/jats:styled-content> or haemophilia. Therefore, this narrative review aims to provide an overview of some important preanalytical aspects that may affect the diagnosis of <jats:styled-content style=\"fixed-case\">VWD<\/jats:styled-content> or haemophilia, as well as a range of solutions that may help in mitigating or abrogating their influence. The review includes discussion of the more commonly noted preanalytical issues, such as haemolysis\/icterus\/lipaemia, and sample collection, processing and transport. However, we also extensively discuss other less well\u2010recognized preanalytical issues, including clinical requests, anticoagulants and anticoagulant therapy, and laboratory test choices to name a few.<\/jats:p>","DOI":"10.1111\/hae.13396","type":"journal-article","created":{"date-parts":[[2017,12,24]],"date-time":"2017-12-24T08:24:40Z","timestamp":1514103880000},"page":"198-210","source":"Crossref","is-referenced-by-count":26,"title":["Preanalytical issues that may cause misdiagnosis in haemophilia and von Willebrand disease"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2103-1661","authenticated-orcid":false,"given":"E. 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