{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T15:46:20Z","timestamp":1762875980349,"version":"3.37.3"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,3,14]],"date-time":"2018-03-14T00:00:00Z","timestamp":1520985600000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>The gaps in haemophilia treatment around the world are enormous; approximately 60% of an estimated 475\u00a0000 individuals are not identified. Of the 187\u00a0000 diagnosed, 30% (57\u00a0000) access clotting factor replacement therapy. Since 1996, humanitarian aid distributed by the World Federation of Hemophilia (<jats:styled-content style=\"fixed-case\">WFH<\/jats:styled-content>) has played a minor, yet vital role providing life\u2010saving clotting factor to countries in emergency situations. Donated amounts have been small and sporadic, often salvaging short\u2010dated products, providing little opportunity to leverage donations with governments. In 2015, a prospective donation programme of 100 million <jats:styled-content style=\"fixed-case\">I.U.<\/jats:styled-content> per year of extended half\u2010life factor <jats:styled-content style=\"fixed-case\">VIII<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">IX<\/jats:styled-content> over 10\u00a0years was established, necessitating the development of new logistics and training programmes by WFH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To measure the impact of a greatly expanded haemophilia humanitarian aid program.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>In 2016, the first full year of the expanded programme, <jats:styled-content style=\"fixed-case\">WFH<\/jats:styled-content>, distributed products to 58 countries with factor <jats:styled-content style=\"fixed-case\">VIII<\/jats:styled-content> usage &lt;1\u00a0I.U. per capita, a level incompatible with long\u2010term survival and far below the 4\u00a0I.U. <jats:styled-content style=\"fixed-case\">FVIII<\/jats:styled-content> per capita minimum established in Europe.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The scope of the programme and utilization data for 2016 indicate primarily use for acute bleeding, orthopaedic and emergency surgeries. Compared to 2014, 2016 data showed substantial increases in patients served (5.9\u2010fold, from 2119 to 14\u00a0579), surgeries performed (37\u2010fold) and bleeds treated (6.9\u2010fold). Patients on prophylaxis rose from 0 to 852, including 458 children under 10\u00a0years old.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>The expanded humanitarian aid programme impacts an estimated 10% of individuals with haemophilia previously unable to access treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This programme represents an unprecedented public\u2010private partnership to deliver medicines to individuals with no access. Further, the programme offers the prospective opportunity to engage governments to take more responsiblity for increasing training, medical management, and product supply in 58 resource constrained countries.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hae.13409","type":"journal-article","created":{"date-parts":[[2018,3,15]],"date-time":"2018-03-15T12:01:57Z","timestamp":1521115317000},"page":"229-235","source":"Crossref","is-referenced-by-count":35,"title":["First\u2010year results of an expanded humanitarian aid programme for haemophilia in resource\u2010constrained countries"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3310-328X","authenticated-orcid":false,"given":"G. 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