{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T10:13:59Z","timestamp":1773483239768,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008648","name":"Pfizer Foundation","doi-asserted-by":"publisher","award":["WI202690"],"award-info":[{"award-number":["WI202690"]}],"id":[{"id":"10.13039\/100008648","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Prevention of arthropathy is the major goal of haemophilia treatment, and early detection of the first signs of joint damage is important so that prevention strategies can be initiated to limit physical disability and improve quality of life.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>\n                      The aim of this study was to determine the inter\u2010rater repeatability of the\n                      <jats:styled-content style=\"fixed-case\">HEAD<\/jats:styled-content>\n                      \u2010\n                      <jats:styled-content style=\"fixed-case\">US<\/jats:styled-content>\n                      protocol when performed by haemophilia physiotherapists.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Sixty\u2010three joints (21 elbows, 21 knees and 21 ankles) were examined in 21 patients (mean age; 29.14\u00a0\u00b1\u00a010.09\u00a0years) according to the\n                      <jats:styled-content style=\"fixed-case\">HEAD<\/jats:styled-content>\n                      \u2010\n                      <jats:styled-content style=\"fixed-case\">US<\/jats:styled-content>\n                      protocol by four of six physiotherapists blinded to clinical information. Inter\u2010rater repeatability was evaluated by comparing the concordance of scores between the different clinicians using weighted Kappa (\u03ba\n                      <jats:sub>w<\/jats:sub>\n                      ) statistics and 95% confidence intervals.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Substantial agreement was found when evaluating synovial hypertrophy (\u03ba\n                      <jats:sub>w<\/jats:sub>\n                      \u00a0=\u00a00.69), articular cartilage (\u03ba\n                      <jats:sub>w<\/jats:sub>\n                      \u00a0=\u00a00.60) and bone (\u03ba\n                      <jats:sub>w<\/jats:sub>\n                      \u00a0=\u00a00.74). Near perfect repeatability (\u03ba\n                      <jats:sub>w<\/jats:sub>\n                      \u00a0&gt;\u00a00.80) was found when scoring synovitis profiles of the elbow joint and bone profiles of the knee joint. Repeatability was moderate for scoring synovitis and articular cartilage profiles of the ankle joint. A moderate correlation between\n                      <jats:styled-content style=\"fixed-case\">HEAD<\/jats:styled-content>\n                      \u2010\n                      <jats:styled-content style=\"fixed-case\">US<\/jats:styled-content>\n                      and\n                      <jats:styled-content style=\"fixed-case\">HJHS<\/jats:styled-content>\n                      was found for the elbow and ankle joint and a strong correlation for the knee joint. Discordance between clinical and ultrasound examination was 19.30%.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Overall, we found repeatability of the\n                      <jats:styled-content style=\"fixed-case\">HEAD<\/jats:styled-content>\n                      \u2010\n                      <jats:styled-content style=\"fixed-case\">US<\/jats:styled-content>\n                      protocol was good when performed by physiotherapists, and our results support the emerging view that\n                      <jats:styled-content style=\"fixed-case\">US<\/jats:styled-content>\n                      imaging complements the physical examination when screening and monitoring joint health of people with haemophilia at the point of care.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hae.13440","type":"journal-article","created":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T07:46:13Z","timestamp":1519890373000},"page":"471-476","source":"Crossref","is-referenced-by-count":24,"title":["Physiotherapist inter\u2010rater reliability of the Haemophilia Early Arthropathy Detection with Ultrasound protocol"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6175-3343","authenticated-orcid":false,"given":"D.","family":"Stephensen","sequence":"first","affiliation":[{"name":"Kent Haemophilia Centre East Kent Hospitals NHS Trust Canterbury  Canterbury UK"},{"name":"Haemophilia Centre Royal London Hospital Barts Health NHS Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Classey","sequence":"additional","affiliation":[{"name":"Haemophilia Centre St Thomas\u2019 Hospital Guys &amp; St Thomas\u2019 NHS Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Harbidge","sequence":"additional","affiliation":[{"name":"Bristol Haemophilia Centre Bristol Children's Hospital University Hospitals Bristol NHS Trust  Bristol UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Patel","sequence":"additional","affiliation":[{"name":"Haemophilia Centre Royal London Hospital Barts Health NHS Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Taylor","sequence":"additional","affiliation":[{"name":"Oxford Haemophilia Centre Churchill Hospital Oxford University Hospitals NHS Trust  Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Wells","sequence":"additional","affiliation":[{"name":"Basingstoke Haemophilia Centre Hampshire Hospitals NHS Foundation Trust  Basingstoke UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2006.01953.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2008.01876.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.12025"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa067659"},{"key":"e_1_2_8_6_1","first-page":"119","article-title":"MR imaging as a screening tool for early detection of arthropathy in hemophilic children: systematic review and recommendations","volume":"18","author":"Chan MW","year":"2012","journal-title":"Haemophilia"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12792"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.13088"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12769"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12637"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.13163"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2010.02380.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.2001.00509.x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.14.12501"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12268"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12876"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH12-11-0874"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.13269"},{"key":"e_1_2_8_19_1","first-page":"601","article-title":"Ultrasound evaluation of haemophilic joints by haemophilia physicians: a reliability study","volume":"13","author":"Fischer K","year":"2015","journal-title":"J Thromb Haemost"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.2307\/2529310"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2006.01312.x"}],"container-title":["Haemophilia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhae.13440","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hae.13440","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T12:07:48Z","timestamp":1695470868000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hae.13440"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["10.1111\/hae.13440"],"URL":"https:\/\/doi.org\/10.1111\/hae.13440","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.735981122.793562048","asserted-by":"object"}]},"ISSN":["1351-8216","1365-2516"],"issn-type":[{"value":"1351-8216","type":"print"},{"value":"1365-2516","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3]]}}}