{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T23:26:28Z","timestamp":1791588388906,"version":"4.3.4"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,3,24]],"date-time":"2018-03-24T00:00:00Z","timestamp":1521849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2018,5]]},"abstract":"Introduction<\/jats:title>Patients with Von Willebrand disease (VWD<\/jats:styled-content>) are regularly treated with VWF<\/jats:styled-content>\u2010containing concentrates in case of acute bleeding, trauma and dental or surgical procedures.<\/jats:p><\/jats:sec>Aim<\/jats:title>In this multicentre retrospective study, current perioperative management with a von Willebrand factor (VWF<\/jats:styled-content>)\/Factor VIII<\/jats:styled-content> (FVIII<\/jats:styled-content>) concentrate (Haemate\u00ae<\/jats:sup> P) in patients with VWD<\/jats:styled-content> was evaluated.<\/jats:p><\/jats:sec>Patients\/Methods<\/jats:title>Patients with VWD<\/jats:styled-content> undergoing minor or major surgery between 2000 and 2015, requiring treatment with a VWF<\/jats:styled-content>\/FVIII<\/jats:styled-content> concentrate (Haemate\u00ae<\/jats:sup> P), were included. Achieved VWF<\/jats:styled-content> activity (VWF<\/jats:styled-content>:Act) and FVIII<\/jats:styled-content> during FVIII<\/jats:styled-content>\u2010based treatment regimens were compared to predefined target levels in national guidelines.<\/jats:p><\/jats:sec>Results<\/jats:title>In total, 103 patients with VWD<\/jats:styled-content> (148 surgeries) were included: 54 type 1 (73 surgeries), 43 type 2 (67 surgeries) and 6 type 3 (8 surgeries). Overall, treatment resulted in high VWF<\/jats:styled-content>:Act and FVIII<\/jats:styled-content> levels, defined as \u22650.20\u00a0IU<\/jats:styled-content>\/mL above predefined levels. In patients with type 1 VWD<\/jats:styled-content>, respectively, 65% and 91% of trough VWF<\/jats:styled-content>:Act and FVIII<\/jats:styled-content> levels were higher than target levels. In patients with type 2 and type 3 VWD<\/jats:styled-content>, respectively, 53% and 57% of trough VWF<\/jats:styled-content>:Act and 72% and 73% of trough FVIII<\/jats:styled-content> levels were higher than target level. Furthermore, FVIII<\/jats:styled-content> accumulation over time was observed, while VWF<\/jats:styled-content>:Act showed a declining trend, leading to significantly higher levels of FVIII<\/jats:styled-content> than VWF<\/jats:styled-content>:Act.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>High VWF<\/jats:styled-content>:Act and accumulation of FVIII<\/jats:styled-content> were observed after perioperative FVIII<\/jats:styled-content>\u2010based replacement therapy in patients with VWD<\/jats:styled-content>, both underlining the necessity of personalization of dosing regimens to optimize perioperative treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hae.13451","type":"journal-article","created":{"date-parts":[[2018,3,24]],"date-time":"2018-03-24T23:47:25Z","timestamp":1521935245000},"page":"460-470","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Analysis of current perioperative management with Haemate\u00ae<\/sup> P\/Humate P\u00ae<\/sup> in von Willebrand disease: Identifying the need for personalized treatment"],"prefix":"10.1111","volume":"24","author":[{"given":"H. C. A. M.","family":"Hazendonk","sequence":"first","affiliation":[{"name":"Department of Paediatric Haematology Erasmus University Medical Centre \u2010 Sophia Children's Hospital Rotterdam Rotterdam Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1069-8097","authenticated-orcid":false,"given":"J. M.","family":"Heijdra","sequence":"additional","affiliation":[{"name":"Department of Paediatric Haematology Erasmus University Medical Centre \u2010 Sophia Children's Hospital Rotterdam Rotterdam Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. C. B.","family":"de Jager","sequence":"additional","affiliation":[{"name":"Hospital Pharmacy \u2010 Clinical Pharmacology Academic Medical Centre Amsterdam Amsterdam Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. C.","family":"Veerman","sequence":"additional","affiliation":[{"name":"Department of Paediatric Haematology Erasmus University Medical Centre \u2010 Sophia Children's Hospital Rotterdam Rotterdam Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Boender","sequence":"additional","affiliation":[{"name":"Department of Haematology Erasmus University Medical Centre Rotterdam Rotterdam Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"van Moort","sequence":"additional","affiliation":[{"name":"Department of Paediatric Haematology Erasmus University Medical Centre \u2010 Sophia Children's Hospital Rotterdam Rotterdam Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. A. A.","family":"Math\u00f4t","sequence":"additional","affiliation":[{"name":"Hospital Pharmacy \u2010 Clinical Pharmacology Academic Medical Centre Amsterdam Amsterdam Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Meijer","sequence":"additional","affiliation":[{"name":"Department of Haematology University of Groningen University Medical Centre Groningen Groningen Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. A. P.","family":"Laros\u2010van Gorkom","sequence":"additional","affiliation":[{"name":"Department of Haematology Radboud University Medical Centre Nijmegen Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Eikenboom","sequence":"additional","affiliation":[{"name":"Department of Thrombosis and Haemostasis Leiden University Medical Centre Leiden Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Fijnvandraat","sequence":"additional","affiliation":[{"name":"Department of Paediatric Haematology Academic Medical Centre Amsterdam Amsterdam Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5677-1371","authenticated-orcid":false,"given":"F. W. G.","family":"Leebeek","sequence":"additional","affiliation":[{"name":"Department of Haematology Erasmus University Medical Centre Rotterdam Rotterdam Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. H.","family":"Cnossen","sequence":"additional","affiliation":[{"name":"Department of Paediatric Haematology Erasmus University Medical Centre \u2010 Sophia Children's Hospital Rotterdam Rotterdam Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the \u201cOPTI\u2010CLOT\u201d and \u201cWIN\u201d study group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,3,24]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V69.2.454.454"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2006.02146.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2010.02320.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-017-0793-2"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-09-603241"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.12514"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2004.00893.x"},{"issue":"2","key":"e_1_2_9_9_1","first-page":"s33","article-title":"Surgical prophylaxis in von Willebrand's disease: a difficult balance to manage","volume":"6","author":"Franchini M","year":"2008","journal-title":"Blood Transfus"},{"key":"e_1_2_9_10_1","first-page":"1279","article-title":"Efficacy and safety of factor VIII\/von Willebrand's factor concentrate (Haemate\u2010P) in preventing bleeding during surgery or invasive procedures in patients with von Willebrand disease","volume":"88","author":"Franchini M","year":"2003","journal-title":"Haematologica"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12561"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/MBC.0000000000000500"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2011.02583.x"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2007.02588.x"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.1999.0050s2064.x"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2011.02534.x"},{"key":"e_1_2_9_17_1","first-page":"1","article-title":"Prophylactic efficacy and pharmacokinetically guided dosing of a von Willebrand factor\/factor VIII concentrate in adults and children with von Willebrand's disease undergoing elective surgery: a pooled and comparative analysis of data from USA and European Union clinical trials","volume":"11","author":"Mannucci PM","year":"2013","journal-title":"Blood Transfus"},{"issue":"2","key":"e_1_2_9_18_1","first-page":"s9","article-title":"Treatment of von Willebrand disease with FVIII\/VWF concentrates","volume":"9","author":"Castaman G","year":"2011","journal-title":"Blood Transfus"},{"key":"e_1_2_9_19_1","article-title":"Richtlijn Diagnostiek en behandeling van hemofilie en aanverwante hemostasestoornissen","volume":"1","author":"Leebeek FWG","year":"2009","journal-title":"Van Zuiden Communications BV"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13064"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2005.01435.x"},{"key":"e_1_2_9_22_1","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1160\/TH05-01-0013","article-title":"Elevated factor VIII is a risk factor for idiopathic venous thromboembolism in Canada \u2010 is it necessary to define a new upper reference range for factor VIII?","volume":"93","author":"Wells PS","year":"2005","journal-title":"Thromb Haemost"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1613227"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2008.01049.x"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12955"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V86.10.3676.bloodjournal86103676"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2009.03678.x"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13064"},{"key":"e_1_2_9_29_1","unstructured":"HillarpA LandorphA Andr\u00e9Holme P PetriniP LassilaR OnundarsonPT.Nordic guidelines for diagnosis and management of von Willebrand disease (VWD).2012."},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.13242"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12258"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12185"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1613225"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/MBC.0000000000000269"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2011.02663.x"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1351-8216.2003.00816.x"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1612977"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2007.01643.x"}],"container-title":["Haemophilia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhae.13451","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hae.13451","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T16:08:52Z","timestamp":1695485332000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hae.13451"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,24]]},"references-count":37,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["10.1111\/hae.13451"],"URL":"https:\/\/doi.org\/10.1111\/hae.13451","archive":["Portico"],"relation":{},"ISSN":["1351-8216","1365-2516"],"issn-type":[{"value":"1351-8216","type":"print"},{"value":"1365-2516","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,24]]},"assertion":[{"value":"2018-01-31","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-03-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}