{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T22:33:58Z","timestamp":1764714838204,"version":"3.37.3"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,3,30]],"date-time":"2018-03-30T00:00:00Z","timestamp":1522368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Bayer Hemophilia Awards Program (Early Career Investigator Award)"},{"name":"ASPIRE 2013 (Pfizer) research grant"},{"name":"World Federation of Haemophilia Clinical Research Grant Program"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To measure passive musculoarticular ankle stiffness (<jats:styled-content style=\"fixed-case\">PMAAS<\/jats:styled-content>) and its intra\u2010 and interday reliability in adult control subjects without ankle disorders. We also sought to quantify <jats:styled-content style=\"fixed-case\">PMAAS<\/jats:styled-content> in children, adolescents and young adults with haemophilia (<jats:styled-content style=\"fixed-case\">CAA<\/jats:styled-content>wH) taking into account the accurate tibiotalar and subtalar joints structural status obtained by magnetic resonance imaging (<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We included 23 <jats:styled-content style=\"fixed-case\">CAA<\/jats:styled-content>wH and 23 typically developing boys (<jats:styled-content style=\"fixed-case\">TDB<\/jats:styled-content>) matched by age, weight and height, along with 25 healthy volunteers for reliability assessment. All <jats:styled-content style=\"fixed-case\">CAA<\/jats:styled-content>wH underwent bilateral ankle <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>, with anatomical status assessed using the International Prophylaxis Study Group <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> scale. All <jats:styled-content style=\"fixed-case\">CAA<\/jats:styled-content>wH underwent <jats:styled-content style=\"fixed-case\">PMAAS<\/jats:styled-content> testing for both sides randomly vs the dominant side (<jats:styled-content style=\"fixed-case\">DS<\/jats:styled-content>) in <jats:styled-content style=\"fixed-case\">TDB<\/jats:styled-content>s. For assessing viscous stiffness (<jats:styled-content style=\"fixed-case\">VS<\/jats:styled-content>) and elastic stiffness (<jats:styled-content style=\"fixed-case\">ES<\/jats:styled-content>), eight different oscillation frequencies were randomly repeated three times for each subject.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Good\u2010to\u2010excellent intra\u2010 and interday reliability was observed for <jats:styled-content style=\"fixed-case\">ES<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">VS<\/jats:styled-content> variables. No relevant differences were observed between the ankle viscoelastic properties in <jats:styled-content style=\"fixed-case\">CAA<\/jats:styled-content>wH without joint damage and matched <jats:styled-content style=\"fixed-case\">TDB<\/jats:styled-content>s, whereas the study revealed significantly increased <jats:styled-content style=\"fixed-case\">ES<\/jats:styled-content> in the affected ankles of <jats:styled-content style=\"fixed-case\">CAA<\/jats:styled-content>wH with severe unilateral joint involvement compared to the non\u2010affected joint.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study confirmed increased <jats:styled-content style=\"fixed-case\">ES<\/jats:styled-content> in the severely affected ankles of <jats:styled-content style=\"fixed-case\">CAA<\/jats:styled-content>wH compared to non\u2010affected sides. No differences in the ankle viscoelastic properties of <jats:styled-content style=\"fixed-case\">CAA<\/jats:styled-content>wH with or without joint damage were observed, however, compared to matched <jats:styled-content style=\"fixed-case\">TDB<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hae.13467","type":"journal-article","created":{"date-parts":[[2018,3,30]],"date-time":"2018-03-30T07:53:41Z","timestamp":1522396421000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Assessment of passive musculoarticular ankle stiffness in children, adolescents and young adults with haemophilic ankle arthropathy"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3829-6850","authenticated-orcid":false,"given":"S.","family":"Lobet","sequence":"first","affiliation":[{"name":"Neuromusculoskeletal Lab (NMSK) Secteur des Sciences de la Sant\u00e9 Institut de Recherche 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Louvain Drug Research Institute Universit\u00e9 catholique de Louvain  Brussels Belgium"},{"name":"Institute of health and society (IRSS) Universit\u00e9 catholique de Louvain  Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5429-8437","authenticated-orcid":false,"given":"C.","family":"Hermans","sequence":"additional","affiliation":[{"name":"Service d'h\u00e9matologie Cliniques universitaires Saint\u2010Luc  Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Detrembleur","sequence":"additional","affiliation":[{"name":"Neuromusculoskeletal Lab (NMSK) Secteur des Sciences de la Sant\u00e9 Institut de Recherche Exp\u00e9rimentale et Clinique Universit\u00e9 catholique de Louvain  Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Deschamps","sequence":"additional","affiliation":[{"name":"Department of rehabilitation sciences 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