{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T03:12:45Z","timestamp":1790824365952,"version":"4.1.0"},"reference-count":9,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,4,6]],"date-time":"2018-04-06T00:00:00Z","timestamp":1522972800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000801","name":"Bayer HealthCare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000801","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004817","name":"Lund University Medical Faculty Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004817","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008322","name":"CSL Behring","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2018,7]]},"abstract":"Introduction<\/jats:title>Patients suffering from von Willebrand disease (VWD<\/jats:styled-content>) have a variety of bleeding symptoms and require both outpatient care for treatment and, in more severe cases, hospitalization.<\/jats:p><\/jats:sec>Aim<\/jats:title>To investigate the impact of having VWD<\/jats:styled-content> on frequency of hospitalization compared to a control group and to evaluate whether regular replacement therapy (prophylaxis) is associated with reduction in the number of hospitalizations.<\/jats:p><\/jats:sec>Methods<\/jats:title>Linkage of national population\u2010based registries was used in the Congenital Bleeding Disorders study in Sweden (CBDS<\/jats:styled-content>). Data were from the von Willebrand Disease Prophylaxis Network (VWD PN<\/jats:styled-content>).<\/jats:p><\/jats:sec>Results<\/jats:title>The national registries contained 2790 subjects with a diagnosis of VWD<\/jats:styled-content> between 1987 and 2009. A total of 13\u00a0920 age\u2010 and gender\u2010matched controls were identified. There were 2.0 times (range 1.5\u20102.5) as many inpatient hospitalizations among subjects with VWD<\/jats:styled-content> compared to controls. The most common causes of hospitalization were gastrointestinal (GI<\/jats:styled-content>) bleeding (n\u00a0=\u00a0232 as primary diagnosis), menorrhagia (n\u00a0=\u00a0198) and epistaxis (n\u00a0=\u00a0192). Outpatient visits per year were also twice as common among those with VWD<\/jats:styled-content>. From the VWD PN<\/jats:styled-content>, 105 subjects were included (VWD<\/jats:styled-content> type 3, 52.4%; type2A, 22.9%; type 1, 12.4% and other types, 3.9%). A total of 122 hospitalizations due to bleeding episodes, dominated by GI<\/jats:styled-content> bleeds, were analysed. Significantly fewer hospitalizations occurred after initiation of prophylaxis (75 prior to and 45 after, P<\/jats:italic>\u00a0=\u00a0.006).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Our study indicates that subjects with VWD<\/jats:styled-content> have a considerably higher consumption of healthcare resources compared to controls and that initiation of prophylaxis may reduce the number of hospitalizations due to bleeding.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hae.13473","type":"journal-article","created":{"date-parts":[[2018,4,7]],"date-time":"2018-04-07T00:39:06Z","timestamp":1523061546000},"page":"628-633","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Bleeding\u2010related hospitalization in patients with von Willebrand disease and the impact of prophylaxis: Results from national registers in Sweden compared with normal controls and participants in the von Willebrand Disease Prophylaxis Network"],"prefix":"10.1111","volume":"24","author":[{"given":"E.","family":"Holm","sequence":"first","affiliation":[{"name":"Department of Translational Medicine Lund University Sk\u00e5ne University Hospital Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2325-5634","authenticated-orcid":false,"given":"K. Steen","family":"Carlsson","sequence":"additional","affiliation":[{"name":"Health Economics Unit Department of Clinical Sciences Lund University Lund Sweden"},{"name":"The Swedish Institute for Health Economics Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"L\u00f6vdahl","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine Lund University Sk\u00e5ne University Hospital Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. E.","family":"Lail","sequence":"additional","affiliation":[{"name":"Rho, Inc. Chapel Hill NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. C.","family":"Abshire","sequence":"additional","affiliation":[{"name":"BloodCenter of Wisconsin and Departments of Pediatrics and Medicine Blood Research Institute Medical College of Wisconsin Milwaukee WI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2888-4931","authenticated-orcid":false,"given":"E.","family":"Berntorp","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine Lund University Sk\u00e5ne University Hospital Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,4,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2012.077263"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12092"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.12995"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2012.02916.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2006.02179.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MBC.0000000000000257"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2011.02745.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH07-11-0698"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.2003.00817.x"}],"container-title":["Haemophilia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhae.13473","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hae.13473","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T01:21:36Z","timestamp":1694395296000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hae.13473"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,6]]},"references-count":9,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,7]]}},"alternative-id":["10.1111\/hae.13473"],"URL":"https:\/\/doi.org\/10.1111\/hae.13473","archive":["Portico"],"relation":{},"ISSN":["1351-8216","1365-2516"],"issn-type":[{"value":"1351-8216","type":"print"},{"value":"1365-2516","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,6]]},"assertion":[{"value":"2018-02-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-04-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}