{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T03:34:38Z","timestamp":1776310478237,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,4,19]],"date-time":"2018-04-19T00:00:00Z","timestamp":1524096000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000801","name":"Bayer HealthCare","doi-asserted-by":"publisher","award":["Early Career Investigator Award 2012"],"award-info":[{"award-number":["Early Career Investigator Award 2012"]}],"id":[{"id":"10.13039\/501100000801","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","award":["ASPIRE 2013"],"award-info":[{"award-number":["ASPIRE 2013"]}],"id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of this study was to determine whether young haemophilic boys with and without <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>\u2010based signs of ankle arthropathy demonstrate reduced balance ability during a transition task with eyes open and eyes closed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010four haemophilic bodies and 28 typically developing boys aged 6\u201020\u00a0years participated to this study. Structural integrity of the tarsal foot joints of all haemophilic boys was assessed with <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>. All participants performed a standard transition task from double\u2010leg stance to single\u2010leg stance with eyes open and eyes closed. Comparison of balance features derived from the centre of pressure displacement captured by a single force platform was performed between the different haemophilia subgroups and sex\u2010age\u2010height matched peers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Findings<\/jats:title><jats:p>The haemophilic boys without signs of arthropathy presented only a higher intermediate phase velocity during the eyes closed condition (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.05). The haemophilic boys with signs of arthropathy had significantly higher displacement after the time to new stability point, and 95% Ellipse Sway Area and Balance Area compared to their matched peers during eyes open test (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05). Similar findings were observed during the eyes closed test for the displacement after the time to new stability point and 95% Ellipse Sway Area (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05). No significant differences were observed between affected and non\u2010affected side of the unilateral affected patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Interpretation<\/jats:title><jats:p>We suggest that the pathophysiological cascade associated with chronic bleeding episodes should not be considered as a \u201csimple\u201d musculoskeletal injury, hence more as a complex neurophysiological dysfunction which may originate both from unilateral and bilateral deterioration of the musculoskeletal system.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hae.13484","type":"journal-article","created":{"date-parts":[[2018,4,19]],"date-time":"2018-04-19T17:13:10Z","timestamp":1524157990000},"page":"667-674","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Postural control during a transition task in haemophilic children, adolescents and young adults with haemophilic ankle arthropathy"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6559-6237","authenticated-orcid":false,"given":"K.","family":"Deschamps","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Sciences Musculoskeletal Rehabilitation Research Group KULeuven  Leuven (Heverlee) Belgium"},{"name":"Division of Podiatry Institut D'Enseignement Sup\u00e9rieur Parnasse Deux\u2010Alice  Sint\u2010Lambrechts\u2010Woluwe Belgium"},{"name":"Department of Podiatry Artevelde University College  Ghent Belgium"},{"name":"Department of Physical Medicine University Hospitals Leuven  Pellenberg Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Staes","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Sciences Musculoskeletal Rehabilitation Research Group KULeuven  Leuven (Heverlee) Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Eerdekens","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine University Hospitals Leuven  Pellenberg Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Peerlinck","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences Centre for Molecular and Vascular Biology KULeuven  Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Hermans","sequence":"additional","affiliation":[{"name":"Service d'h\u00e9matologie Cliniques Universitaires Saint\u2010Luc  Bruxelles Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Vandesande","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences Centre for Molecular and Vascular Biology KULeuven  Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3829-6850","authenticated-orcid":false,"given":"S.","family":"Lobet","sequence":"additional","affiliation":[{"name":"Service d'h\u00e9matologie Cliniques Universitaires Saint\u2010Luc  Bruxelles Belgium"},{"name":"Secteur des Sciences de la Sant\u00e9 Institut de Recherche Exp\u00e9rimentale et Clinique Neuromusculoskeletal Lab (NMSK) Universit\u00e9 catholique de Louvain  Brussels Belgium"},{"name":"Service de m\u00e9decine physique et r\u00e9adaptation Cliniques universitaires Saint\u2010Luc  Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,4,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1871"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2003-37938"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1300954"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-01-528414"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gaitpost.2010.04.002"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22193"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2010.02200.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2007.01613.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12106"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12369"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.2001.00563.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.13368"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2012.02883.x"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12338"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2013.06.026"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiomech.2015.01.002"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1123\/jsr.19.1.98"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports-2013-092690"}],"container-title":["Haemophilia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhae.13484","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hae.13484","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T01:20:29Z","timestamp":1694395229000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hae.13484"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,19]]},"references-count":18,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,7]]}},"alternative-id":["10.1111\/hae.13484"],"URL":"https:\/\/doi.org\/10.1111\/hae.13484","archive":["Portico"],"relation":{},"ISSN":["1351-8216","1365-2516"],"issn-type":[{"value":"1351-8216","type":"print"},{"value":"1365-2516","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,19]]},"assertion":[{"value":"2018-03-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication 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