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This contrasts to the bulk of literature in other pain conditions, such as osteoarthritis, low back pain or rheumatoid arthritis. Understanding the complexity of pain allows to better assess and manage pain. In PwH, the first priority is always to exclude bleeding as a cause of pain. An important next step in pain assessment is the evaluation of the predominant pain mechanism (ie nociceptive, neuropathic pain or altered central pain processing) as the treatment approach will be very different according to the underlying pain mechanism. Pain assessment should include both physiological and psychological components. This review summarizes the evidence regarding nociceptive, neuropathic and altered central pain processing in PwH and serves as a research agenda to prioritize pain research in PwH.<\/jats:p>","DOI":"10.1111\/hae.13509","type":"journal-article","created":{"date-parts":[[2018,5,31]],"date-time":"2018-05-31T22:57:23Z","timestamp":1527807443000},"page":"3-8","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Gaining insight into the complexity of pain in patients with haemophilia: State\u2010of\u2010the\u2010art review on pain processing"],"prefix":"10.1111","volume":"24","author":[{"given":"N. 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