{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:16:03Z","timestamp":1740125763734,"version":"3.37.3"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,6,29]],"date-time":"2018-06-29T00:00:00Z","timestamp":1530230400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Invasive orthopaedic interventions (<jats:styled-content style=\"fixed-case\">IOI<\/jats:styled-content>) are often used to control recurrent haemarthrosis, pain and loss of joint function, in males with haemophilia (Factor <jats:styled-content style=\"fixed-case\">VIII<\/jats:styled-content> and Factor <jats:styled-content style=\"fixed-case\">IX<\/jats:styled-content> deficiency).<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>Identify risk factors associated with <jats:styled-content style=\"fixed-case\">IOI<\/jats:styled-content>s in males with haemophilia enrolled in the Universal Data Collection (<jats:styled-content style=\"fixed-case\">UDC<\/jats:styled-content>) surveillance program from 2000 until 2010.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data were collected on <jats:styled-content style=\"fixed-case\">IOI<\/jats:styled-content>s performed on patients receiving care in 130 haemophilia treatment centers in the United States annually by health care providers using standardized forms. <jats:styled-content style=\"fixed-case\">IOI<\/jats:styled-content>s included in this study are as follows: 1) synovectomy and 2) arthrodesis or arthroplasty (A\/A). Information about potential risk factors was obtained from the preceding <jats:styled-content style=\"fixed-case\">UDC<\/jats:styled-content> visit if available, or from the same visit if not. Patients with no reported <jats:styled-content style=\"fixed-case\">IOI<\/jats:styled-content> at any of their <jats:styled-content style=\"fixed-case\">UDC<\/jats:styled-content> visits were the reference group for the analysis. Multivariate analyses were conducted to identify independent risk factors for synovectomies and arthrodesis\/arthroplasty.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Risk factors significantly associated with the two <jats:styled-content style=\"fixed-case\">IOI<\/jats:styled-content> categories were age, student status, haemophilia severity, number of joint bleeds within the last 6\u00a0months, <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> or hepatitis C (<jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>) status. Multivariate analyses showed patients on continuous prophylaxis were 50% less likely to have had a synovectomy and were 40% less likely to have an A\/A.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study shows modifiable risk factors, including management of bleeding episodes with a continuous prophylactic treatment schedule are associated with a decreased likelihood of <jats:styled-content style=\"fixed-case\">IOI<\/jats:styled-content>s in males with haemophilia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hae.13511","type":"journal-article","created":{"date-parts":[[2018,6,29]],"date-time":"2018-06-29T12:49:31Z","timestamp":1530276571000},"page":"964-970","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Risk factors associated with invasive orthopaedic interventions in males with haemophilia enrolled in the Universal Data Collection program from 2000 to 2010"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1622-5103","authenticated-orcid":false,"given":"P.","family":"Tobase","sequence":"first","affiliation":[{"name":"Hemophilia Treatment Center University of California  San Francisco CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Lane","sequence":"additional","affiliation":[{"name":"Intermountain Hemophilia and Thrombosis Center Primary Children's Medical Center  Salt Lake City UT USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.\u2010E.\u2010A","family":"Siddiqi","sequence":"additional","affiliation":[{"name":"Division of Blood Disorders Centers for Disease Control and Prevention (CDC)  Atlanta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. M.","family":"Soucie","sequence":"additional","affiliation":[{"name":"Division of Blood Disorders Centers for Disease Control and Prevention (CDC)  Atlanta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Ingram\u2010Rich","sequence":"additional","affiliation":[{"name":"LEND@OHSU  Portland OR USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Ward","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy University of Utah College of Health  Salt Lake City UT USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. C.","family":"Gill","sequence":"additional","affiliation":[{"name":"Medical College of Wisconsin and Comprehensive Center for Bleeding Disorders Blood Center of Wisconsin  Milwaukee WI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the Hemophilia Treatment Center Network (HTCN) Study Investigators","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,6,29]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1613540"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.2002.00604.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2007.01590.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.2000.00375.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-200403000-00019"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1297-319X(02)00008-8"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.C.01609"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2009.07613.x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2010.02248.x"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2009.12.023"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12398"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12932"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2011.09.002"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1615621"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.1992.tb00546.x"},{"issue":"2","key":"e_1_2_9_17_1","first-page":"4","article-title":"Comparing prophylaxis with episodic treatment in haemophilia A: implications for clinical practice","volume":"13","author":"Manco\u2010Johnson M","year":"2007","journal-title":"Haemophilia"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.2002.00695.x"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-200309000-00010"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2008.01763.x"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.5435\/00124635-200401000-00008"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2010.02400.x"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-014-3507-6"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH09-09-0629"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/1759720X16671927"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000000952"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa067659"}],"container-title":["Haemophilia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhae.13511","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hae.13511","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T10:33:07Z","timestamp":1694687587000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hae.13511"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,29]]},"references-count":26,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,11]]}},"alternative-id":["10.1111\/hae.13511"],"URL":"https:\/\/doi.org\/10.1111\/hae.13511","archive":["Portico"],"relation":{},"ISSN":["1351-8216","1365-2516"],"issn-type":[{"type":"print","value":"1351-8216"},{"type":"electronic","value":"1365-2516"}],"subject":[],"published":{"date-parts":[[2018,6,29]]},"assertion":[{"value":"2018-04-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-06-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}